| Draper Cuts Ltd | Other services | 2026 |
| Drayton Partners Group Limited | Administrative & support | 2026 |
| Drayton Partners Limited | Professional & scientific | 2010 |
| Draíocht North Ltd | Construction | 2024 |
| Drcleancreps Ltd | Administrative & support | 2020 |
| Drcr Consultancy Ltd | Health & social care | 2021 |
| Drcr Properties Limited | Real estate | 2021 |
| DRD Aviation Ltd | Manufacturing | 2021 |
| Dream and DO IT Limited | Information & communication | 2022 |
| Dream Burger Limited | Hospitality | 2022 |
| Dream Dessert Cafe Ltd | Hospitality | 2026 |
| Dream Face Atelier Ltd | Other services | 2023 |
| Dream House Aesthetics Ltd | Other services | 2023 |
| Dream Maker Properties Ltd | Real estate | 2025 |
| Dream VR Ltd | Construction | 2022 |
| Dreaming Beds 2 Ltd | Wholesale & retail | 2025 |
| Dreams Forecourt Limited | Wholesale & retail | 2019 |
| Dreamtide Consulting Limited | Wholesale & retail | 2024 |
| Dreamweddings Ltd | Professional & scientific | 2025 |
| Dreamworld Cakes Ltd | Hospitality | 2015 |
| Dreemz Properties Ltd | Real estate | 2021 |
| Drenchd Ltd | Manufacturing | 2025 |
| Drew Mangan Groundworks Ltd | Construction | 2008 |
| Drey Developments Limited | Other services | 1998 |
| DRF Sports Coaching Ltd | Arts & recreation | 2023 |
| Drft Studios Limited | Professional & scientific | 2025 |
| DRG Prop Ltd | Real estate | 2020 |
| Drian Ltd | Professional & scientific | 2019 |
| Drink Art Bar Limited | Hospitality | 2018 |
| Drink Express Benwell Limited | Wholesale & retail | 2019 |
| Drink Express Westdenton Ltd | Wholesale & retail | 2021 |
| Drinkeld Family Investments Limited | Financial services | 2025 |
| Drinks Delivered Newcastle Ltd | Hospitality | 2020 |
| Drinks Delivered Twenty Four Seven Limited | Hospitality | 2016 |
| Drinx Holdings Limited | Administrative & support | 2016 |
| Drinx Leisure Limited | Hospitality | 2013 |
| Drip Addict Limited | Wholesale & retail | 2024 |
| Drippy Cat Software Limited | Information & communication | 2011 |
| Drive 2024 Limited | Education | 2024 |
| Drive Left Ltd | Wholesale & retail | 2025 |
| Drive Research Limited | Other services | 2022 |
| Drive Rite North East Limited | Wholesale & retail | 2023 |
| Driven by Digital Ltd | Other services | 2018 |
| Driveright Repairs Ltd | Wholesale & retail | 2025 |
| Driving Force Exec Limited | Transport & logistics | 2023 |
| Driving Lessons Limited | Education | 2026 |
| Drivrr Ltd | Information & communication | 2026 |
| Drone Studio North East Ltd | Information & communication | 2023 |
| Drop by Local Ltd | Wholesale & retail | 2022 |
| Droplab Ltd | Wholesale & retail | 2025 |
| Dropwave Global Ltd | Wholesale & retail | 2026 |
| Drovix Limited | Wholesale & retail | 2021 |
| DRS Distribution Ltd | Wholesale & retail | 2022 |
| DRS Land Regeneration Ltd | Water & waste | 2021 |
| Druid Integrated Ltd | Wholesale & retail | 2023 |
| Drummond Central Limited | Professional & scientific | 2004 |
| Drummond Central Trustee Limited | Professional & scientific | 2023 |
| Drvinodh Ltd | Health & social care | 2025 |
| Drvn Analytics Ltd | Information & communication | 2026 |
| Drwas Ltd | Professional & scientific | 2015 |
| Dryden Court RTM Company Limited | Real estate | 2010 |
| Dryden Developments Ltd | Real estate | 2025 |
| Drywall Solutions UK Limited | Construction | 2005 |
| DS Builders Bricklaying & Stonework Specialists Ltd | Construction | 2026 |
| DS Burger Ltd | Hospitality | 2025 |
| DS Recruit Ltd | Administrative & support | 2019 |
| DS Solar & Power Limited | Construction | 2023 |
| DS Stocked Ltd | Wholesale & retail | 2026 |
| DS World Technology Consulting Limited | Information & communication | 2019 |
| Dsbbrickwork Ltd | Construction | 2026 |
| DSD Grab Hire and Aggregates Ltd | Administrative & support | 2024 |
| DSD Properties (NE) Limited | Real estate | 2017 |
| DSG CAD Ltd | Professional & scientific | 2020 |
| DSH Bathrooms Ltd | Construction | 2024 |
| Dsjh Holdings Ltd | Real estate | 2019 |
| DSL Homes Limited | Real estate | 2017 |
| Dslne Ltd | Hospitality | 2025 |
| DSM Services Ltd | Construction | 2021 |
| DSP Access Rigging & Lifting Limited | Construction | 2017 |
| Dsplumbing Services Limited | Construction | 2025 |
| DT Construction NE Ltd | Construction | 2016 |
| DT Decorating Services Ltd | Construction | 2020 |
| DT Elite Scholars Limited | Education | 2025 |
| DT Property Investment Limited | Real estate | 2025 |
| DT Resourcing Ltd | Administrative & support | 2019 |
| DT Roofing Systems Ltd | Construction | 2025 |
| DT38 Foundation | Health & social care | 2014 |
| DTB Inspection Ltd | Professional & scientific | 2024 |
| DTE Global Limited | Transport & logistics | 2026 |
| DTH Consulting Services Ltd | Professional & scientific | 2018 |
| DTM Cars Ltd | Wholesale & retail | 2013 |
| Dtmtec Ltd | Professional & scientific | 2024 |
| Dtrhair Ltd | Other services | 2025 |
| DTT Commercial Consultants Ltd | Professional & scientific | 2023 |
| DTU Ltd | Construction | 2025 |
| Dual Ambition Limited | Construction | 2016 |
| Dubai Shawarma & Grill (NE) Ltd | Hospitality | 2025 |
| DUE North East Consulting Ltd | Professional & scientific | 2014 |
| DUE North East Limited | Administrative & support | 2010 |
| Duggal Properties & Investments Ltd | Wholesale & retail | 2020 |