| DOM Shanley Wall & Floor Tiling Specialist Ltd | Construction | 2021 |
| Domain Property Investments Limited | Real estate | 2019 |
| Dome Project Management Limited | Construction | 2021 |
| Dome Propco Limited | Real estate | 2007 |
| Domegrand Limited | Real estate | 2002 |
| Domiki Developments Ltd | Construction | 2019 |
| Dominic and Jessica Ltd | Other services | 2026 |
| Dominic's Gentlemen's Hairdressers Limited | Other services | 2003 |
| Dominique Morrison Consulting Limited | Professional & scientific | 2017 |
| Domus Improvements Limited | Administrative & support | 2023 |
| Don'T Stall Driving School Ltd | Education | 2026 |
| Donaghy Orange Ltd | Administrative & support | 2022 |
| Doner Direct Limited | Wholesale & retail | 2025 |
| Dong Sheng 888 Limited | Wholesale & retail | 2023 |
| Dongard Contract Services Limited | Construction | 2005 |
| Doniel Booker Ltd | Wholesale & retail | 2025 |
| Donner BOY Newcastle Ltd | Hospitality | 2026 |
| Donoghue Joinery Ltd | Construction | 2016 |
| Donr Group Ltd | Information & communication | 2016 |
| Donr Ltd | Information & communication | 2016 |
| Doodle Properties Limited | Real estate | 2018 |
| Dooglebooks Limited | Wholesale & retail | 2018 |
| Doone Silver Kerr Limited | Professional & scientific | 2010 |
| DOORS-4-U Limited | Construction | 2017 |
| Doorstep VET Company Ltd | Professional & scientific | 2021 |
| Doras Hardware Limited | Administrative & support | 2003 |
| Dorbel Limited | Transport & logistics | 2026 |
| Dosa Kitchen Limited | Hospitality | 2015 |
| Dossier Technologies Ltd | Information & communication | 2024 |
| DOT Aesthetics Ltd | Health & social care | 2024 |
| Dot.Com Computers Ltd | Information & communication | 2019 |
| Dotty in the Kitchen Ltd | Hospitality | 2025 |
| Double Diner ( N. E ) Ltd | Hospitality | 2019 |
| Double Diner Jesmond Dene Ltd | Hospitality | 2026 |
| Double J Solutions Ltd | Information & communication | 2026 |
| Double Pole Electrical Solutions Limited | Construction | 2022 |
| Double Smash Burger Limited | Hospitality | 2025 |
| Double Y Central Ltd | Real estate | 2021 |
| Double Y Grainger Ltd | Hospitality | 2020 |
| Double Y Jesmond Ltd | Hospitality | 2022 |
| Double Y Ltd | Hospitality | 2019 |
| Double Y Seaburn Ltd | Hospitality | 2024 |
| Double Y ST James Ltd | Hospitality | 2024 |
| Double Yummy Indian Ltd | Manufacturing | 2025 |
| Doug Green: Educational Consultant Limited | Education | 2003 |
| Dough 2 Dough Ltd | Wholesale & retail | 2025 |
| Douglas Maritime Limited | Other services | 2014 |
| Douglas Shaw Limited | Professional & scientific | 2002 |
| Douglas Stephens & Co Limited | Professional & scientific | 2008 |
| Douglas Supplies Ltd | Wholesale & retail | 2002 |
| Douglasroofingandbuilding Ltd | Construction | 2020 |
| Douze Ltd | Hospitality | 2025 |
| Dove Marine Limited | Administrative & support | 2000 |
| Dove Nest Ltd | Construction | 2026 |
| Dove Park (North Tyneside) Management Company Limited | Households | 2016 |
| Dover Road Investments Limited | Real estate | 2011 |
| Dovetail Financial Solutions Limited | Professional & scientific | 2023 |
| DOW Coatings Specialists Ltd | Construction | 2024 |
| Dowling Development Limited | Real estate | 2024 |
| Downton’S Consultancy Limited | Information & communication | 2023 |
| Doxford Retreat Ltd | Hospitality | 2026 |
| Doyle Property Investments Ltd | Real estate | 2018 |
| DP & LW Services (North East) Limited | Extraterritorial | 2024 |
| DP Construction N E Limited | Construction | 2009 |
| DP Landscape Architecture Ltd | Professional & scientific | 2013 |
| DP Shot Bar Ltd | Hospitality | 2021 |
| Dp-Av Technologies Ltd | Professional & scientific | 2025 |
| Dpab Limited | Real estate | 2021 |
| DPC Screeding Ltd | Construction | 1984 |
| Dpcds Ltd | Health & social care | 2022 |
| DPD Services Ltd | Mining & quarrying | 2016 |
| DPL Construction ( NE) Ltd | Construction | 2022 |
| DPL Group NE Ltd | Construction | 2025 |
| DPL Kebab Ltd | Hospitality | 2023 |
| DPO Jobs Ltd | Administrative & support | 2026 |
| DPS Tyneside Ltd | Construction | 2020 |
| DR C Fraser Ltd | Health & social care | 2015 |
| DR C. Dipper Ltd | Health & social care | 2018 |
| DR Clare Mcgill Ltd | Administrative & support | 2024 |
| DR Fiona Steedman Ltd | Health & social care | 2026 |
| DR Foods NE Limited | Hospitality | 2024 |
| DR Gudipati Services Limited | Health & social care | 2015 |
| DR Health Advisers Limited | Health & social care | 2021 |
| DR Issing Ltd | Health & social care | 2013 |
| DR Nicola Aesthetics Ltd | Health & social care | 2026 |
| DR Ojechi Medical Services Ltd | Health & social care | 2015 |
| DR Paul Wilkinson Pain Expert Limited | Health & social care | 2019 |
| DR Peptides Ltd | Wholesale & retail | 2025 |
| DR Practice Limited | Real estate | 2010 |
| DR Sarah Mills Independent Paediatrics Ltd | Health & social care | 2025 |
| DR TM Services Ltd | Health & social care | 2019 |
| DR Trish Davis Limited | Health & social care | 2025 |
| DR24 Mobile Ltd | Wholesale & retail | 2019 |
| Dragon City Newcastle Limited | Hospitality | 2014 |
| Dragon Fire Studio Ltd | Information & communication | 2026 |
| Dragon Foodservices Ltd | Wholesale & retail | 2019 |
| Dragonfly Venture (Trading) Limited | Manufacturing | 2011 |
| Dragonfly Venture Properties Ltd | Real estate | 2016 |
| Dragonwaz Limited | Wholesale & retail | 2025 |
| Draktus Ltd | Other services | 2016 |