| Design North Limited | Construction | 2013 |
| Design Services Group Ltd | Financial services | 2025 |
| Design US NAI Ltd | Professional & scientific | 2024 |
| Designe Ltd | Professional & scientific | 2017 |
| Designer Landscapes Maintenance Limited | Administrative & support | 2023 |
| Designer Patios and Landscapes Ltd | Administrative & support | 2022 |
| Designers Drive Ltd | Construction | 2024 |
| Desirable Developments Limited | Construction | 2023 |
| Deskon Technologies Ltd | Other services | 2018 |
| Desmo Corse Limited | Wholesale & retail | 2025 |
| Desnor Limited | Hospitality | 2009 |
| Dessert LAB NCL Ltd | Hospitality | 2022 |
| Dessert Royale Ltd | Hospitality | 2022 |
| Desserts Delivered Property Ltd | Other services | 2014 |
| Dessoky Limited | Health & social care | 2022 |
| Destination Loading CIC | Education | 2026 |
| DESTUDIO360 Ltd | Professional & scientific | 2024 |
| Deta Group Limited | Other services | 2017 |
| Detail Code Ltd | Wholesale & retail | 2023 |
| Detail Properties Limited | Households | 1983 |
| Detailrecruitment Group Ltd | Information & communication | 2018 |
| Determined Consult Ltd | Administrative & support | 2013 |
| DEV Matrix Limited | Wholesale & retail | 2026 |
| Devais Developments Limited | Real estate | 2019 |
| Devais Property Limited | Real estate | 2019 |
| Devalia Clinics Ltd | Manufacturing | 2019 |
| Devcraft Labs Ltd | Information & communication | 2024 |
| Develop Dent Limited | Education | 2024 |
| Develop North PLC | Financial services | 2016 |
| Developing Consensus Limited | Other services | 2024 |
| Develrx Limited | Professional & scientific | 2019 |
| Devereux Architecture Limited | Professional & scientific | 2001 |
| Devero Ltd | Hospitality | 2022 |
| Devine Decorators Ltd | Construction | 2023 |
| Devon EYE Centres Ltd | Health & social care | 2015 |
| Devonshire House Care Limited | Health & social care | 2006 |
| Devoptimize Ltd | Information & communication | 2017 |
| Devs Consultancy Limited | Information & communication | 2018 |
| DEW Drop Gardening Ltd | Construction | 2024 |
| Dexter Landscaping Limited | Administrative & support | 2024 |
| Dexter Renovations Ltd | Construction | 2026 |
| Dexzcrown Clothing Ltd | Wholesale & retail | 2025 |
| DF Power Services Ltd | Construction | 2024 |
| DFA Group Holdings Limited | Financial services | 2026 |
| DFB Group Holdings Limited | Financial services | 2026 |
| DG Contracting Solutions Ltd | Construction | 2023 |
| DG Joinery Services Limited | Construction | 2015 |
| DG Worldwide Marketing Limited | Other services | 2015 |
| Dgfl Limited | Professional & scientific | 2016 |
| Dghc Harrison Limited | Real estate | 2020 |
| Dgray Ltd | Professional & scientific | 2023 |
| DH Benvenuto Ltd | Hospitality | 2019 |
| DH Mechanical Fitting Ltd | Manufacturing | 2025 |
| DH Newcastle Properties Ltd | Real estate | 2024 |
| DH Pharm Ltd | Wholesale & retail | 2021 |
| DH1 Restaurants Limited | Hospitality | 2025 |
| Dhaak Limited | Professional & scientific | 2021 |
| DHARANI21 Ltd | Hospitality | 2026 |
| Dhariwal Medical Limited | Health & social care | 2009 |
| DHB NE Ltd | Construction | 2024 |
| DHF Storage Ltd | Transport & logistics | 2021 |
| Dhillon Chippy Ltd | Hospitality | 2023 |
| Dhillon Properties (NE) Limited | Real estate | 2020 |
| Dhillon's Properties Brockwell Limited | Real estate | 2011 |
| Dhillons Distribution (NE) Ltd | Wholesale & retail | 2024 |
| Dhillons Fish Inn Hebburn Limited | Hospitality | 2005 |
| Dhillons Fish Inn Throckley Limited | Hospitality | 2005 |
| Dhillons Longbenton Ltd | Hospitality | 2024 |
| Dhillons Whitley Bay Limited | Administrative & support | 2020 |
| DHS IT Solutions Ltd | Information & communication | 2016 |
| DHT Interior Ltd | Construction | 2023 |
| DI Service Ltd | Administrative & support | 2024 |
| Dia&Yo Ltd | Transport & logistics | 2026 |
| Dial a Drink (NE) Ltd | Wholesale & retail | 2025 |
| Dial a Drink Newcastle Limited | Wholesale & retail | 2007 |
| Dial Square Capital Limited | Financial services | 2016 |
| Diallo Capital Ltd | Financial services | 2020 |
| Diambaxi Ltd | Wholesale & retail | 2026 |
| Diamond Choice Cars Ltd | Wholesale & retail | 2017 |
| Diamond Clean (UK) Limited | Administrative & support | 2012 |
| Diamond's Stores Ltd | Wholesale & retail | 2023 |
| Diaspora Kitchen Limited | Hospitality | 2026 |
| Diaspora Logistics Ltd | Professional & scientific | 2021 |
| Diaspora Synergy Limited | Hospitality | 2024 |
| Dibra Newcastle Ltd | Hospitality | 2020 |
| Dice Pizza Newcastle Ltd | Hospitality | 2025 |
| Dick Extracts and Formulations (D.E.F) Limited | Wholesale & retail | 2025 |
| Dickinson Deliveries Limited | Wholesale & retail | 2022 |
| Dickinson Shoe Services Limited | Other services | 1961 |
| Dicksons Van World Limited | Wholesale & retail | 1997 |
| DID Consultants Limited | Professional & scientific | 2021 |
| Diesel & Marine Services Ltd | Manufacturing | 2014 |
| Different Advertising Design and Marketing Limited | Professional & scientific | 1999 |
| Different Narrative Integrated Marketing Limited | Professional & scientific | 2020 |
| Differentology Consulting Limited | Financial services | 2020 |
| Differentology Limited | Professional & scientific | 2013 |
| Digger Guard Limited | Manufacturing | 2023 |
| Digicove Ltd | Real estate | 2020 |
| DIGIMARK10 Ltd | Information & communication | 2025 |
| Digipro Design Ltd | Professional & scientific | 2023 |