| Defoite Limited | Real estate | 2009 |
| Defoort Consultant Ltd | Professional & scientific | 2023 |
| Dehaty Hardaker Estates Ltd | Real estate | 2006 |
| Deivós Limited | Information & communication | 2015 |
| Dejavu Video Limited | Information & communication | 2003 |
| Dejonghe & Morley LLP | | 2025 |
| Deka Resources Limited | Wholesale & retail | 2018 |
| Delaval Arms PUB Company Ltd | Hospitality | 2023 |
| Delaval Court Management Company Limited | Households | 1999 |
| Delaval Properties Limited | Real estate | 2000 |
| Delcron Limited | Professional & scientific | 2017 |
| Deleon Trading Limited | Administrative & support | 2019 |
| Delfina Kozik Ltd | Information & communication | 2025 |
| Deli Delights Northern Limited | Wholesale & retail | 2004 |
| Deli Espresso Gosforth Limited | Hospitality | 2017 |
| Deli Espresso NE Limited | Hospitality | 2017 |
| Deli Express/Dinners Express West Denton Ltd | Hospitality | 2022 |
| Deli Fresh NE Ltd | Hospitality | 2018 |
| Delicious Decadence Limited | Wholesale & retail | 2012 |
| Delite Cleaning Services Ltd | Administrative & support | 2025 |
| Dell Holdings Ltd | Real estate | 2020 |
| Dellow Commerce Ltd | Wholesale & retail | 2026 |
| Delpha Limited | Professional & scientific | 2020 |
| Delport Solutions Limited | Administrative & support | 2015 |
| Delta Multiplex Holdings Ltd | Professional & scientific | 2018 |
| Delta Multiplex Overview Ltd | Professional & scientific | 2018 |
| Delta Properties NE Ltd | Real estate | 2025 |
| Delta Property Management Limited | Real estate | 2008 |
| Deltodesco Holdings Ltd | Financial services | 2025 |
| Deluca Rayhill Limited | Other services | 2010 |
| Deluxe Building & Cleaning Ltd | Administrative & support | 2022 |
| Deluxe Detailing Ltd | Administrative & support | 2025 |
| Deluxe Express Limited | Other services | 1997 |
| Deluxe Flooring Limited | Wholesale & retail | 2015 |
| Deluxe Homes Developments Limited | Extraterritorial | 2007 |
| Deluxe Solutions Ltd | Transport & logistics | 2025 |
| Delville Wood Limited | Professional & scientific | 2013 |
| Delya Ltd | Transport & logistics | 2026 |
| DEM Art Collective CIC | Education | 2026 |
| Demdev Ltd | Information & communication | 2025 |
| Dementia Matters | Health & social care | 1994 |
| Demesnet Ltd | Information & communication | 2026 |
| Deminos Ltd | Professional & scientific | 2007 |
| Demivalkud Industries Ltd | Professional & scientific | 2026 |
| Demmysoft Global Resources Ltd | Administrative & support | 2024 |
| Demolition Recordings Limited | Other services | 2020 |
| Demyraas Properties Ltd | Real estate | 2025 |
| Demystify Sexual Health Ltd | Health & social care | 2025 |
| Dencall 2005 Ltd | Health & social care | 2005 |
| Dene Barbers Ltd | Other services | 2025 |
| Dene Court Maintenance Limited | Households | 2000 |
| Dene Foundation Ltd | Health & social care | 2023 |
| Dene Grange Residents Association Limited | Households | 1970 |
| Dene House - LOW Fell RTM Limited | Households | 2024 |
| Dene Park Investments Limited | Extraterritorial | 2024 |
| Deneside Court (Jesmond) Maintenance Limited | Real estate | 1986 |
| Deneside Court (NO. 2) Management Limited | Real estate | 1989 |
| Deneside Court Freehold 1 Limited | Real estate | 2017 |
| Deneside Court Freehold 2 Limited | Real estate | 2017 |
| Denewell Haulage Ltd | Transport & logistics | 2026 |
| Denham Electrical Ltd | Construction | 2024 |
| Denison Consulting (UK) Limited | Extraterritorial | 2010 |
| Denlat Property Management LLP | | 2022 |
| Dentadura Ltd | Administrative & support | 2023 |
| Dental Oasis Ltd | Health & social care | 2024 |
| Dentecom Limited | Extraterritorial | 2000 |
| Dentium Limited | Administrative & support | 2023 |
| Denton 5 Ltd | Wholesale & retail | 2021 |
| Denton Barber Shop Ltd | Other services | 2025 |
| Denton Burn Community Association | Arts & recreation | 2013 |
| Denton Car Wash (N.E) Limited | Wholesale & retail | 2021 |
| Denton Cycles Limited | Manufacturing | 2023 |
| Denton MOT and Service Centre Ltd | Wholesale & retail | 2021 |
| Denton Nails & Spa Ltd | Other services | 2024 |
| Denton Nails Ltd | Other services | 2024 |
| Denton Travel Limited | Transport & logistics | 2008 |
| Denton Youth & Community Project Limited | Other services | 2011 |
| Depa Trading Limited | Wholesale & retail | 2022 |
| Depend Group Limited | Financial services | 2020 |
| Dependable Delivery Limited | Transport & logistics | 2026 |
| Dependable Medical Devices Limited | Health & social care | 2019 |
| Deramore Mortgage Company Limited | Real estate | 1976 |
| Derek Bell Sports Ltd | Arts & recreation | 2026 |
| Derek O'Brien Creative Solutions Limited | Information & communication | 2013 |
| Derma UK Holdings Limited | Professional & scientific | 2014 |
| Derma UK Limited | Wholesale & retail | 1996 |
| Dermal Radiance Ltd | Wholesale & retail | 2024 |
| Dermavisage Aesthetics Ltd | Health & social care | 2017 |
| Dermdiagnostics Ltd. | Health & social care | 2015 |
| Derwent Developments (Curzon) Limited | Construction | 2006 |
| Derwent Developments Limited | Construction | 1985 |
| Derwent Express Limited | Hospitality | 2025 |
| Derwent Lodge Management Company Limited | Households | 2017 |
| Derwent Lotus Limited | Hospitality | 2021 |
| Derwent View Property Management Company Limited | Real estate | 2007 |
| DES Fashion Ltd | Wholesale & retail | 2019 |
| Desi Bites Ltd | Hospitality | 2017 |
| Desi Mazza Ltd | Hospitality | 2025 |
| Desi Sangat NE Ltd | Arts & recreation | 2026 |
| Design F Limited | Professional & scientific | 2013 |