| Digishout Ltd | Professional & scientific | 2025 |
| Digistartup Ltd | Information & communication | 2023 |
| Digistem Ltd. | Information & communication | 2019 |
| Digital Alkemy Limited | Information & communication | 2014 |
| Digital Audio & Computer Systems (Manufacturing and Marketing) Limited | Wholesale & retail | 1987 |
| Digital Capability Exchange UK Limited | Other services | 2025 |
| Digital Collections Limited | Wholesale & retail | 2021 |
| Digital Crayon Limited | Information & communication | 2024 |
| Digital Doves Limited | Professional & scientific | 2019 |
| Digital Marketing House Ltd | Professional & scientific | 2012 |
| Digital Media Distribution Ltd | Professional & scientific | 2013 |
| Digital Media Distribution Services Limited | Professional & scientific | 2020 |
| Digital Mortgages Limited | Extraterritorial | 2014 |
| Digital Sales LAB Ltd | Professional & scientific | 2018 |
| Digital Shac Limited | Information & communication | 2025 |
| Digital Sidekick Limited | Information & communication | 2009 |
| Digital Sparks Club CIC | Education | 2024 |
| Digital Staffing Solutions Ltd | Health & social care | 2023 |
| Digital Vita Holdings Limited | Real estate | 2021 |
| Digital YOU CIC | Professional & scientific | 2026 |
| Digitalcrush Limited | Information & communication | 2013 |
| Digitalfire Ltd | Information & communication | 2015 |
| Digitalized Ltd | Information & communication | 2013 |
| Digitaltec Engineering Ltd | Construction | 2019 |
| Digitalvapers Ltd | Wholesale & retail | 2021 |
| Dilawaiz Store Limited | Wholesale & retail | 2025 |
| Dilek London Limited | Administrative & support | 2025 |
| Dilshad E Store Ltd | Wholesale & retail | 2025 |
| Dilysen Limited | Professional & scientific | 2019 |
| Dima Auto Cars Limited | Wholesale & retail | 2021 |
| Dimar Construct Ltd | Construction | 2026 |
| Dimedic Limited | Information & communication | 2014 |
| Dimension 5 Solutions Group Limited | Information & communication | 2018 |
| Dimeplace Limited | Real estate | 1997 |
| Dimondx Mart Ltd | Wholesale & retail | 2025 |
| DIN 334 Ltd | Real estate | 2022 |
| Diner Express Limited | Hospitality | 2023 |
| Dining Oasis Ltd | Hospitality | 2025 |
| Dinmont Ltd | Administrative & support | 2025 |
| Dinnington Convenience Stores Limited | Wholesale & retail | 2023 |
| Dinnington Cuisine Ltd | Hospitality | 2025 |
| Dinosauria Limited | Education | 2015 |
| Dinr.Ai Ltd | Health & social care | 2025 |
| Dinta Group Ltd | Wholesale & retail | 2025 |
| Diocese of Hexham and Newcastle | Other services | 2011 |
| Dioz Ltd | Real estate | 2025 |
| DIP Commercial Limited | Administrative & support | 2017 |
| Diploma & Hernandez Properties Ltd | Real estate | 2023 |
| Dipp'D by Filto Ltd | Hospitality | 2026 |
| Dipping Donuts Events Limited | Wholesale & retail | 2022 |
| Dipton Pharmacy Limited | Wholesale & retail | 2025 |
| Dirani Limited | Wholesale & retail | 2023 |
| Direct Business Wear Limited | Manufacturing | 2016 |
| Direct Cars Forest Hall Ltd | Transport & logistics | 2014 |
| Direct Catering Solutions Ltd | Energy | 2020 |
| Direct Debit Solutions Limited | Information & communication | 2013 |
| Direct Immigration Solutions Bureau Limited | Professional & scientific | 2022 |
| Direct Internet Services for the Community Limited | Information & communication | 1999 |
| Direct Line Clothing Ltd | Wholesale & retail | 2005 |
| Direct Plastering Services NE Ltd | Construction | 2023 |
| Direct Property NE Ltd | Real estate | 2024 |
| Direct Property Services (N/E) Ltd | Construction | 2025 |
| Direct Scaffolding Services NE Ltd. | Construction | 2021 |
| Direct Technology UK Limited | Administrative & support | 2005 |
| Directional Drilling Solutions UK Limited | Construction | 2016 |
| Direkt Engineering Holdings Limited | Real estate | 2012 |
| Direkt Engineering Services Limited | Manufacturing | 1999 |
| Dirty Murphy's Ltd | Administrative & support | 2023 |
| Dirty Wild Wings Ltd | Hospitality | 2025 |
| Disability North | Health & social care | 1983 |
| Disc Limited | Wholesale & retail | 2003 |
| Disciple Skincare Limited | Wholesale & retail | 2016 |
| Disco Cat Investments Limited | Real estate | 2021 |
| Disco Sound Light Limited | Arts & recreation | 2024 |
| Discount Seller Ltd | Wholesale & retail | 2025 |
| Discount Tyres Newcastle Limited | Wholesale & retail | 2019 |
| Dispatch One Ltd | Transport & logistics | 2025 |
| Disruptional Ltd | Information & communication | 2015 |
| Dissington Hall Limited | Real estate | 2026 |
| Dissington Investments Limited | Financial services | 2015 |
| Distinctive Media Group Limited | Administrative & support | 2014 |
| Distinguished Care 3 Limited | Health & social care | 2025 |
| Distinguished Care Group Limited | Health & social care | 2025 |
| Distinkt Limited | Professional & scientific | 2023 |
| District 26 Ltd | Wholesale & retail | 2026 |
| Dive Medics Ltd | Health & social care | 2003 |
| Dive Street Ltd | Wholesale & retail | 2022 |
| Dive Street Two Ltd | Hospitality | 2024 |
| Divecor Adventures CIC | Education | 2021 |
| Divercity Hub CIC | Health & social care | 2021 |
| Divers Street Ltd | Hospitality | 2024 |
| Divine DEV Solutions Ltd | Wholesale & retail | 2025 |
| Divine Inns Limited | Hospitality | 2012 |
| Divine Properties Europe Ltd | Real estate | 2026 |
| Divine Uplifting Ltd | Extraterritorial | 2022 |
| Divinepearl's Events Limited | Hospitality | 2017 |
| Divita Finance Limited | Information & communication | 2023 |
| Dixon and Anwar Holdings Ltd | Wholesale & retail | 2023 |
| Dixon Brothers Contracting LLP | | 2024 |
| Dixon Construction ( North East ) Limited | Construction | 2012 |