| Sarah Bayne Consulting Limited | Professional & scientific | 2014 |
| Sarah Creations Ltd | Information & communication | 2013 |
| Sarah Fearnley Property Developments Limited | Construction | 2024 |
| Sarah Hagan Interior Design Ltd | Real estate | 2021 |
| Sarah Mason Accountancy Limited | Extraterritorial | 2005 |
| Sarah Mclusky Ltd | Professional & scientific | 2022 |
| Sarahemma Photography Ltd | Professional & scientific | 2026 |
| Saraj Aurangzaib Logistics Ltd | Transport & logistics | 2025 |
| Saray Turkish Restaurant Ltd | Hospitality | 2021 |
| Sarbat Healthcare Ltd | Health & social care | 2024 |
| Sarchnar Restaurant Limited | Hospitality | 2023 |
| Sarcount Limited | Professional & scientific | 2026 |
| Sarmstrong Energy Services Ltd | Construction | 2017 |
| Saro CUT Ltd | Other services | 2026 |
| Sarola Trade and Service Limited | Real estate | 2026 |
| Sarren Deliveries Ltd | Transport & logistics | 2025 |
| Saruja Investment Management Limited | Financial services | 2026 |
| SAS Accountancy Services Ltd | Professional & scientific | 2020 |
| SAS Carpet and Upholstery Cleaning Ltd | Administrative & support | 2025 |
| SAS Properties (NE) Ltd | Construction | 2023 |
| SAS Properties North Limited | Real estate | 2024 |
| Sast Ltd | Wholesale & retail | 2013 |
| Satellite Installation Services (Northern) Limited | Information & communication | 1989 |
| Satiroglu Ltd | Hospitality | 2024 |
| Saulire LLP | | 2009 |
| Saunders and Purves Limited | Other services | 1948 |
| Saunderson-Darkes Optoms Limited | Health & social care | 2022 |
| Savage & Co Payments Ltd | Administrative & support | 2026 |
| Savage Silk Limited | Professional & scientific | 2014 |
| Savage Strength Ltd | Arts & recreation | 2020 |
| Savanah Healthcare Services Ltd | Health & social care | 2021 |
| Savannah K&M Limited | Other services | 2003 |
| Savant Maintenance Ltd | Construction | 2023 |
| Savarino Properties Limited | Real estate | 2025 |
| Savay Hospitality Ltd | Hospitality | 2026 |
| Saveions Ltd | Professional & scientific | 2022 |
| Savihaan Ltd | Health & social care | 2021 |
| Saville House (the Grove) Management Limited | Real estate | 2006 |
| Saving Spot Ltd | Wholesale & retail | 2023 |
| Savioc Group Ltd | Professional & scientific | 2026 |
| Savour & Swirl Ltd | Hospitality | 2025 |
| Sawyer Brewing Limited | Manufacturing | 2021 |
| Saxton Property Holdings Limited | Real estate | 2021 |
| SAY When Ltd | Hospitality | 2025 |
| Saye's to Go Ltd | Hospitality | 2021 |
| Sayfi Ltd | Wholesale & retail | 2020 |
| Sayturk Group Limited | Hospitality | 2012 |
| SAZ Furniture Limited | Wholesale & retail | 2019 |
| SAZ Healthcare Ltd | Health & social care | 2026 |
| SB 1978 Homes Limited | Real estate | 2022 |
| SB and CB Property Holdings Limited | Real estate | 2026 |
| SB Automotive Detailing Ltd | Wholesale & retail | 2026 |
| SB Chiro Ltd | Health & social care | 2023 |
| SB Clothing NCL Ltd | Wholesale & retail | 2023 |
| SB Developments (Durham) Limited | Other services | 2019 |
| SB Travels Ltd | Administrative & support | 2015 |
| Sb-Ag Holdings Ltd | Professional & scientific | 2021 |
| Sb-Rg Limited | Administrative & support | 2026 |
| Sbbhr Limited | Extraterritorial | 2025 |
| SBK Newcastle Group Limited | Professional & scientific | 2024 |
| SBL Holiday LET Cleaning Services Ltd | Administrative & support | 2025 |
| SBV Law Ltd | Professional & scientific | 2020 |
| SC Access Ltd | Construction | 2016 |
| SC Benton Coffee Ltd | Hospitality | 2025 |
| SC Electrical Ltd | Construction | 2018 |
| SC Garden Services Ltd | Administrative & support | 2010 |
| SC Industrial Solutions Ltd | Construction | 2014 |
| SC Properties (NE) Limited | Real estate | 2024 |
| SC Retail Ltd | Wholesale & retail | 2016 |
| SC Stores Ltd | Wholesale & retail | 2016 |
| SC Technical Solutions Ltd | Construction | 2024 |
| Scalcs Ltd | Professional & scientific | 2018 |
| Scales Informatics Ltd | Information & communication | 2013 |
| Scalp North East Limited | Other services | 2017 |
| SCAN2RECYCLE Limited | Professional & scientific | 2017 |
| Scandilife Investments Ltd | Real estate | 2003 |
| Scans Accounting Limited | Professional & scientific | 2021 |
| Scarborough and District Motor Services Limited | Extraterritorial | 1987 |
| Scarlet Butterfly Media Limited | Information & communication | 2017 |
| SCD (2021) Ltd | Manufacturing | 2016 |
| Scent Gems Ltd | Wholesale & retail | 2026 |
| Scented Melts Ltd | Other services | 2019 |
| Scentsation Global UK Limited | Manufacturing | 2025 |
| SCG Electrical Services Limited | Professional & scientific | 2015 |
| Schatzberger Limited | Real estate | 2019 |
| Schatzberger Medical Services Limited | Health & social care | 2022 |
| Schilling Robotics Limited | Professional & scientific | 2003 |
| Schmööze (Newcastle) Ltd. | Wholesale & retail | 2017 |
| Schnell Ltd | Wholesale & retail | 2024 |
| Scholar's Court Residents Association Limited | Real estate | 1986 |
| Scholars Conferences Limited | Information & communication | 2019 |
| Scholars Green (Management) Limited | Real estate | 2011 |
| School of Studies Limited | Education | 2012 |
| Schools Northeast Trading Ltd | Education | 2014 |
| Schwarzwald Limited | Wholesale & retail | 2013 |
| Science and Maths Limited | Education | 2004 |
| Scigrip Adhesives Limited | Administrative & support | 2010 |
| Scisco (UK) Limited | Professional & scientific | 2012 |
| SCL Oswald Limited | Professional & scientific | 2019 |
| Scmf Property Management Limited | Real estate | 2026 |