| SAM Kirby Limited | Construction | 2022 |
| Samahshay UK Ltd | Wholesale & retail | 2018 |
| Samari Auto Ltd | Wholesale & retail | 2021 |
| Samba Health and Social Care Consulting Ltd | Health & social care | 2026 |
| Sambuca (TT2) Ltd | Hospitality | 2025 |
| Sambuca Benton Limited | Hospitality | 2024 |
| Sambuca Braise Station Ltd | Hospitality | 2018 |
| Sambuca BRO Ltd | Hospitality | 2022 |
| Sambuca Forest Hall Ltd | Hospitality | 2017 |
| Sambuca Garden Kitchen Newcastle Ltd | Hospitality | 2019 |
| Sambuca Pavillion Ltd | Hospitality | 2017 |
| Sambuca Quayside Newcastle Ltd | Hospitality | 2024 |
| Sameena Bashey Consulting Limited | Professional & scientific | 2020 |
| Sameer Khan Enterprises Ltd | Financial services | 2025 |
| Samko Cars Limited | Wholesale & retail | 2019 |
| Sammich Ltd | Hospitality | 2026 |
| Sammy Bear Day Care Limited | Health & social care | 2024 |
| Samrat M Ltd | Health & social care | 2020 |
| Sams Physio Limited | Health & social care | 2024 |
| Samsara Holdings Ltd | Wholesale & retail | 2019 |
| Samshc Ltd | Health & social care | 2025 |
| Samson Autos Limited | Wholesale & retail | 2023 |
| Samuel Knight Energy Ltd | Professional & scientific | 2023 |
| Samuel Knight Holdings Limited | Administrative & support | 2018 |
| Samuel Knight International Limited | Administrative & support | 2014 |
| Samuel Knight Projects Limited | Construction | 2022 |
| Samuel Phillips Newcastle Limited | Professional & scientific | 2017 |
| Samy Sales Ltd | Transport & logistics | 2025 |
| Samyoul Limited | Information & communication | 2015 |
| SAN Studios Ltd | Financial services | 2023 |
| Sana Retails NE Ltd | Wholesale & retail | 2026 |
| Sana Stores Ltd | Wholesale & retail | 2025 |
| Sanago Ltd | Real estate | 2019 |
| Sanam Empire Ltd | Wholesale & retail | 2024 |
| Sanam Travel Ltd | Administrative & support | 2022 |
| Sanandini Enterprises Limited | Wholesale & retail | 2023 |
| Sanbrands Limited | Manufacturing | 2007 |
| Sanco Pizza Ltd | Hospitality | 2023 |
| Sanctuary Consultancy Limited | Professional & scientific | 2023 |
| Sanctuary Student Living Limited | Real estate | 2026 |
| Sanctus Consulting Ltd | Professional & scientific | 2009 |
| Sand & Snow Ltd | Wholesale & retail | 2025 |
| Sandbrook Meadows Management Company Limited | Households | 2020 |
| Sandco 1195 Limited | Real estate | 2011 |
| Sandco 1290 | Other services | 2021 |
| Sandco 2021 Limited | Financial services | 2021 |
| Sandco 830 Limited | Real estate | 2004 |
| Sanders Plant & Waste Management Limited | Administrative & support | 2007 |
| Sanderson Education Hub CIC | Education | 2025 |
| Sanderson Property Group (North East) Limited | Real estate | 2024 |
| Sandfield Management Limited | Professional & scientific | 2021 |
| Sandfire Technologies Limited | Information & communication | 2011 |
| Sandhill Mews Management Company Limited | Real estate | 2004 |
| Sandhu Investment NE Ltd | Real estate | 2023 |
| Sandhu Letting Express Ltd | Real estate | 2025 |
| Sandhu Lettings Ltd | Hospitality | 2025 |
| Sandila Ltd | Wholesale & retail | 2025 |
| Sandman Hotel Group (UK) Limited | Hospitality | 2009 |
| Sandringham Meadows (Blyth) Management Limited | Real estate | 2007 |
| Sands Electrical Worx Ltd | Extraterritorial | 2018 |
| Sands of Tyne Ltd | Hospitality | 2022 |
| Sands Plumbing and Heating Limited | Extraterritorial | 2019 |
| Sandvvich Co. Oylum Ltd | Hospitality | 2026 |
| Sandwell Capital Ltd | Real estate | 2024 |
| Sandwell Group Ltd | Real estate | 2024 |
| Sandwichez Ltd | Hospitality | 2025 |
| Sandy Lane Caravans Ltd | Arts & recreation | 2024 |
| Sandyford Student Lets Ltd | Households | 2025 |
| Sandylane Truckparc Limited | Transport & logistics | 2023 |
| Sanfresh Limited | Manufacturing | 2009 |
| Sangenic International Ltd. | Manufacturing | 1977 |
| Sanghya Limited | Health & social care | 2024 |
| Sania (UK) Limited | Wholesale & retail | 2010 |
| Sanispectra Limited | Other services | 2019 |
| Sanivar UK Limited | Administrative & support | 2018 |
| Sanjay-Anita Consulting PVT Limited | Health & social care | 2016 |
| Sanjith UK Ltd | Hospitality | 2024 |
| Sankris Limited | Real estate | 2020 |
| Sanskrit Restaurant Ltd | Hospitality | 2024 |
| Santana Whickham Ltd | Hospitality | 2017 |
| Santco Limited | Real estate | 2014 |
| Santos Business Solutions Ltd | Administrative & support | 2025 |
| Sanwash Limited | Manufacturing | 2009 |
| Saoban Limited | Hospitality | 2026 |
| SAP Traffic Ltd | Construction | 2025 |
| Sapien Records Ltd | Arts & recreation | 2010 |
| Sapien Songs Ltd | Arts & recreation | 2010 |
| Sapience Vector Limited | Information & communication | 2026 |
| Sapindaceae Limited | Professional & scientific | 2018 |
| Sapphire Bars Limited | Hospitality | 2016 |
| Sapphire Builds Limited | Construction | 2017 |
| Sapphire E Consulting Ltd | Professional & scientific | 2023 |
| Sapphire Homes (NE) Limited | Construction | 2014 |
| Sapphire Technologies Limited | Information & communication | 1996 |
| Saps Services Limited | Professional & scientific | 2026 |
| Saqifah Ltd | Other services | 2018 |
| Sara M Beauty Salon Ltd | Wholesale & retail | 2016 |
| Sara Vening Consulting Ltd | Professional & scientific | 2020 |
| Sarah Afify Ltd | Health & social care | 2024 |
| Sarah Bamford Ltd | Professional & scientific | 2017 |