| Sabokemi Limited | Hospitality | 2014 |
| Sabrin YA Amigo Limited | Construction | 2025 |
| Sabus Group Ltd | Financial services | 2022 |
| Sabus Properties 1 Ltd | Real estate | 2017 |
| Sabus Properties Ltd | Real estate | 2015 |
| Sachins Limited | Real estate | 1988 |
| Sadaat Developments Ltd | Other services | 2022 |
| Sadberge Management Company 2025 Ltd | Households | 2025 |
| Saddle Skedaddle Limited | Administrative & support | 1999 |
| Sadin Liberty Ltd. | Other services | 2015 |
| Sadiq Property Investment Limited | Real estate | 2024 |
| Sadiq Property Limited | Real estate | 2020 |
| Sadler Brown Limited | Professional & scientific | 2009 |
| Saela Sauna Ltd | Health & social care | 2024 |
| Safa Travel Services Limited | Administrative & support | 2019 |
| Safari Estates Limited | Hospitality | 2004 |
| Safaé Beauty Limited | Other services | 2025 |
| Safdar Properties Ltd | Real estate | 2022 |
| Safdar Stores Limited | Wholesale & retail | 2025 |
| Safe 24/7 Call OUT Ltd | Construction | 2020 |
| Safe and Secure Utilities Ltd | Construction | 2024 |
| Safe Clicks UK CIC | Education | 2025 |
| Safe Families for Children | Other services | 2012 |
| Safe Hands Home Care Limited | Health & social care | 2003 |
| Safe Haven - a RAY of Hope | Other services | 2019 |
| Safedox Ltd | Information & communication | 2024 |
| Safeguard Autonomy Ltd | Health & social care | 2026 |
| Safeguard Digital Ltd | Professional & scientific | 2025 |
| Safehaven BNB Homes & Lettings Ltd | Hospitality | 2019 |
| Safer Spaces Newcastle CIC | Information & communication | 2026 |
| Safety 4 HED LLP | | 2010 |
| Saffron Durham Limited | Hospitality | 2014 |
| Saffron Property Services (NE) Ltd | Hospitality | 2012 |
| Safi Sungreen Infrastructure Ltd | Construction | 2026 |
| Safina Asjid Limited | Health & social care | 2021 |
| Sage (UK) Ltd | Information & communication | 1972 |
| Sage Euro Hedgeco 1 | Financial services | 2013 |
| Sage Euro Hedgeco 2 | Financial services | 2013 |
| Sage FAR East Investments Limited | Financial services | 2004 |
| Sage Global Services Limited | Administrative & support | 2015 |
| Sage Holding Company Limited | Financial services | 2012 |
| Sage Holdings Limited | Professional & scientific | 1998 |
| Sage Investment (NE) LLP | | 2010 |
| Sage Online Holdings Limited | Information & communication | 2011 |
| Sage Overseas Limited. | Professional & scientific | 1990 |
| Sage People Limited | Information & communication | 2007 |
| Sage Pharma Ltd | Health & social care | 2023 |
| Sage Treasury Company Limited | Financial services | 2012 |
| Sage US LLP | | 2017 |
| Sage USD Hedgeco 1 | Financial services | 2013 |
| Sage USD Hedgeco 2 | Financial services | 2013 |
| Sage Whitley Limited | Professional & scientific | 2006 |
| Sagesoft | Information & communication | 1990 |
| Saggar (NE) Limited | Real estate | 2015 |
| Saggar Leisure Limited | Real estate | 2026 |
| Saggar Ltd | Real estate | 2019 |
| Sagiri Limited | Health & social care | 2023 |
| Sahilia Ltd | Manufacturing | 2025 |
| Saigon Nails Limited | Other services | 2013 |
| Sainal Technologies Ltd | Information & communication | 2025 |
| Saint & Clark Limited | Real estate | 1963 |
| Saint James Convenience Store Ltd | Wholesale & retail | 2025 |
| Saint Jude PVT Limited | Wholesale & retail | 2022 |
| Saint Vincent Limited | Hospitality | 2005 |
| Saints Hair Limited | Other services | 2026 |
| SAJ Transport Consultants Ltd | Professional & scientific | 2007 |
| Sajy Mobile Mechanic Ltd | Wholesale & retail | 2024 |
| SAK Retail Ltd | Wholesale & retail | 2018 |
| Saka Kitchen Ltd | Hospitality | 2025 |
| Saker Capital LLP | | 2017 |
| Saki Investment Ltd | Real estate | 2025 |
| Sakura Chinese Massage Ltd | Health & social care | 2019 |
| Sakura Homes Ltd | Real estate | 2024 |
| Sakura Stays Ltd | Real estate | 2021 |
| Sale PFI FM Limited | Extraterritorial | 2001 |
| Sale PFI Limited | Administrative & support | 2002 |
| Saleem Abbas Properties Ltd | Real estate | 2026 |
| Sales Boost AI Ltd | Information & communication | 2025 |
| Sales Capability Partners Ltd | Professional & scientific | 2015 |
| Sales Confidence Ltd | Administrative & support | 2018 |
| Sales Magnet Holdings Limited | Information & communication | 2024 |
| Salestechnic Limited | Professional & scientific | 2019 |
| Salih Pharmaceuticals Ltd | Health & social care | 2021 |
| Sally French-Teeling Limited | Wholesale & retail | 1990 |
| Salmon Bars Limited | Hospitality | 2016 |
| Salon 66 Limited | Administrative & support | 2003 |
| Salon BE Ltd | Other services | 2023 |
| Salon Sugar Ltd | Other services | 2023 |
| Salseduce Dancing Ltd | Arts & recreation | 2026 |
| Salt and Code Ltd | Information & communication | 2009 |
| Saltbox Surveying Limited | Professional & scientific | 2021 |
| Salters Living Ltd | Real estate | 2026 |
| Saltwater Property and Investment Ltd | Real estate | 2022 |
| Saltwell Properties Ltd | Real estate | 2021 |
| Salty Sea Dog Limited | Hospitality | 2018 |
| Salty Therapy Ltd | Health & social care | 2018 |
| Saltzman Consulting Ltd | Administrative & support | 2022 |
| Salvatore Cook Ltd | Professional & scientific | 2019 |
| Salvivo Limited | Other services | 2021 |
| SAM Heslop Roofing Ltd | Construction | 2019 |