| S K GAS & Utilities Ltd | Construction | 2024 |
| S K Pharmacare Limited | Wholesale & retail | 2011 |
| S K Thompson Services Ltd | Health & social care | 2026 |
| S L D Risk Solutions Ltd | Administrative & support | 2022 |
| S M Hussain & Co Ltd | Professional & scientific | 2014 |
| S Malik Ltd | Health & social care | 2017 |
| S Mavin Groundworks Ltd | Administrative & support | 2021 |
| S Mcinnes Ltd | Other services | 2020 |
| S Murray Jewellers (Newcastle) Limited | Wholesale & retail | 2016 |
| S N a Khan Ltd | Health & social care | 2022 |
| S O Gardening Services Limited | Administrative & support | 2012 |
| S P Packaging Supplies Limited | Manufacturing | 2016 |
| S R Piping Solutions Ltd | Professional & scientific | 2014 |
| S Relph Electrical Ltd | Energy | 2015 |
| S S Prestige Ltd | Administrative & support | 2024 |
| S S Prestige Promotions Ltd | Administrative & support | 2024 |
| S Singh (NE) Ltd | Hospitality | 2019 |
| S T R Enterprises Limited | Hospitality | 1996 |
| S U Health Limited | Health & social care | 2021 |
| S U N BRI Limited | Real estate | 2025 |
| S V Plant Services Ltd | Construction | 2019 |
| S V Rutter Ltd | Construction | 1979 |
| S W L 688 Ltd | Other services | 2023 |
| S W R 1 Investments & Properties Limited | Real estate | 2024 |
| S Welch Supplies Ltd | Wholesale & retail | 2023 |
| S Yau-Rosher Limited | Professional & scientific | 2016 |
| S Zwan Locum Ltd | Health & social care | 2025 |
| S&A Consultancy (NE) Ltd | Health & social care | 2024 |
| S&A Hayat Ltd | Wholesale & retail | 2025 |
| S&A Property Group Limited | Real estate | 2025 |
| S&B Developments (NE) Limited | Real estate | 2016 |
| S&B Properties N.E Limited | Real estate | 2025 |
| S&C Group Holdings Ltd | Hospitality | 2026 |
| S&D Brierley Ltd | Construction | 2016 |
| S&F Foster Holdings Ltd | Hospitality | 2025 |
| S&G Store Ltd | Wholesale & retail | 2026 |
| S&I Home Improvements Ltd | Construction | 2026 |
| S&J Property Services and Lettings Ltd | Real estate | 2024 |
| S&M Access Ltd | Construction | 2019 |
| S&N Beauty Co Ltd | Other services | 2025 |
| S&R Assets Ltd | Professional & scientific | 2024 |
| S&R Sports Ltd | Administrative & support | 2014 |
| S&S Attire Newcastle Limited | Wholesale & retail | 2022 |
| S&S Brickwork (NE) Ltd | Construction | 2017 |
| S&S GM Limited | Administrative & support | 2023 |
| S&S Law Solicitors Ltd | Professional & scientific | 2023 |
| S&S Love Construction Limited | Construction | 2024 |
| S&S Marine Services Ltd | Wholesale & retail | 2023 |
| S&S Nair Limited | Financial services | 2023 |
| S&S NE Ltd | Real estate | 2025 |
| S&S North East Limited | Hospitality | 2021 |
| S&Z Hospitality Limited | Real estate | 2022 |
| S-Line Logistics Ltd | Wholesale & retail | 2026 |
| S. Jennings (Plant Hire) Limited | Administrative & support | 1962 |
| S. Jones Group Limited | Administrative & support | 2020 |
| S. Sowerby Bricklaying Services Limited | Construction | 2003 |
| S.A. Fashions Limited | Wholesale & retail | 1999 |
| S.C. Builders North East Limited | Construction | 2014 |
| S.C.Wiper Roadworks Limited | Construction | 2018 |
| S.D.S.K Limited | Real estate | 1989 |
| S.E.A Recycling Ltd | Professional & scientific | 2024 |
| S.Finneran Electrical, Heating, Plumbing Ltd | Construction | 2018 |
| S.G.W. Construction Group Limited | Construction | 1982 |
| S.Hay E-Commerce Ltd | Wholesale & retail | 2025 |
| S.K. Locksmith Ltd | Other services | 2023 |
| S.K.I.L. Training Ltd | Education | 2020 |
| S.L Henry Limited | Wholesale & retail | 2020 |
| S.M. Raza & Sons Ltd | Wholesale & retail | 2019 |
| S.M.P. (Services) Limited | Administrative & support | 1986 |
| S.Mathew Limited | Health & social care | 2023 |
| S.Nepali Limited | Real estate | 2010 |
| S.S. Distribution Ltd | Information & communication | 2020 |
| S.T. Swaddle Ltd | Real estate | 1971 |
| S.Y Electrical and Construction Limited | Construction | 2020 |
| S.Y Maintenance Ltd | Construction | 2023 |
| S2K Convenience Ltd | Wholesale & retail | 2025 |
| S3 Retail PVT Ltd | Wholesale & retail | 2026 |
| S4L Community Ltd | Education | 2017 |
| S4S Traders Limited | Real estate | 2021 |
| S7 Packaging Services Limited | Administrative & support | 2025 |
| S9 Designs Ltd | Professional & scientific | 2026 |
| SA & a Consultancy Ltd | Professional & scientific | 2023 |
| SA Mario One Ltd | Hospitality | 2026 |
| SA Performing Arts Centre Limited | Education | 2008 |
| SA Properties Agency Ltd | Real estate | 2024 |
| SA Stobbs Logistics Ltd | Transport & logistics | 2025 |
| SAA (Newcastle) Properties Limited | Real estate | 2022 |
| SAA Consultancy (NE) Ltd | Education | 2026 |
| Saaa Limited | Wholesale & retail | 2025 |
| Saaaf Ltd | Wholesale & retail | 2022 |
| Saam Private Hire Ltd | Transport & logistics | 2023 |
| Saams International Ltd | Wholesale & retail | 2026 |
| Saaz NE Ltd | Wholesale & retail | 2026 |
| Saaz Property Developments Ltd | Real estate | 2025 |
| Sab's Barber (Hawler) Ltd | Other services | 2024 |
| Sab's Barber (NE) Ltd | Other services | 2025 |
| Sab's MEN Hair Design Ltd | Other services | 2024 |
| Sabai Hairdressing Ltd | Other services | 2010 |
| Sabeh Property Management Ltd | Construction | 2024 |
| Saberton Barnside Ltd | Real estate | 2014 |