| Scne Limited | Education | 2024 |
| Scocal Limited | Wholesale & retail | 2024 |
| Scope 360 Recruitment Ltd | Administrative & support | 2022 |
| Scope Mechanical Services Ltd | Construction | 2024 |
| Scotch on the Racks Limited | Construction | 2016 |
| Scotswood Natural Community Garden Limited | Education | 2011 |
| Scotswood Village Nursery (Newcastle Upon Tyne) Community Interest Company | Education | 2014 |
| Scott & Twigg Health Limited | Health & social care | 2011 |
| Scott and Baron LLP | | 2014 |
| Scott Bros. Inc Ltd | Wholesale & retail | 2024 |
| Scott Brown Piping Ltd | Administrative & support | 2015 |
| Scott FD Consulting Limited | Professional & scientific | 2025 |
| Scott Jointing Limited | Construction | 2018 |
| Scott Logic Limited | Administrative & support | 2005 |
| Scott Stobart Limited | Professional & scientific | 2017 |
| Scottoffshore Ltd | Professional & scientific | 2025 |
| Scotts Holdco Ltd | Manufacturing | 2018 |
| Scotts of Whittington Limited | Construction | 2010 |
| Scotts Skip Hire Ltd | Water & waste | 2024 |
| Scovex Limited | Professional & scientific | 2009 |
| Scranmart Ltd | Hospitality | 2022 |
| Scranners Ltd | Hospitality | 2020 |
| Scratch Golf Pro Shop Limited | Wholesale & retail | 2025 |
| Scream for Pizza Ltd | Hospitality | 2017 |
| Scream Holdings Limited | Financial services | 2023 |
| Scream Slices Ltd | Hospitality | 2018 |
| Scream Sunderland Limited | Hospitality | 2023 |
| Screen & Forster Services Design Consultancy Limited | Professional & scientific | 2007 |
| Scrimshaws Cleaning and Sanitising Services Limited | Administrative & support | 2026 |
| Scrubbers Supreme Cleaning Limited | Administrative & support | 2013 |
| Scrubhive Services Limited | Administrative & support | 2025 |
| Scrutinize Accounts and Bookkeeping Services Limited | Professional & scientific | 2021 |
| Scuba-Life Training Ltd | Education | 2017 |
| Sculpt Ashington Limited | Arts & recreation | 2023 |
| Sculpt Group Limited | Real estate | 2017 |
| Scurty Family Healthcare Limited | Health & social care | 2024 |
| Scylla Engineering Newcastle Ltd | Construction | 2024 |
| SD Barristers Ltd | Professional & scientific | 2025 |
| SD Infra Limited | Real estate | 2022 |
| SD IT Resource Ltd | Information & communication | 2025 |
| SD Property (NE) Group Ltd | Real estate | 2024 |
| SD Property Services Ltd | Construction | 2021 |
| SD3 Inspection Engineering Limited | Extraterritorial | 2022 |
| SDA Pharma Limited | Professional & scientific | 2019 |
| SDH Medical Limited | Health & social care | 2019 |
| SDK Ramshaw Ltd | Hospitality | 2012 |
| Sdmk Ltd | Construction | 2026 |
| SDN Mesma Group Ltd | Professional & scientific | 2006 |
| SDP Services Ltd | Professional & scientific | 2025 |
| SDY Limited | Wholesale & retail | 2003 |
| SE Technology Partners Ltd | Information & communication | 2026 |
| Sea Change Power Ltd | Professional & scientific | 2025 |
| Sea FAB Limited | Manufacturing | 1985 |
| Sea Island (D& B) Limited | Construction | 2025 |
| Sea Island Developments (Gainsborough) Limited | Real estate | 2021 |
| Sea Island Developments (North Shields) Limited | Real estate | 2020 |
| Sea Island Developments (Pelaw) Limited | Real estate | 2019 |
| Sea Island Developments (Ponteland) Limited | Construction | 2016 |
| Sea Island Developments (Spalding) Limited | Real estate | 2022 |
| Sea Island Developments Limited | Construction | 2016 |
| Sea Pizza Ltd | Hospitality | 2022 |
| Sea Property Holdings Ltd | Real estate | 2021 |
| Sea Property Partners Ltd | Real estate | 2019 |
| Seacliff Holdings Limited | Financial services | 2025 |
| Seafield (Seahouses) Management Company Limited | Extraterritorial | 2013 |
| Seaham Smiles Ltd | Health & social care | 2025 |
| Seahorse Solutions Ltd | Professional & scientific | 2025 |
| Seal Shore Ltd. | Hospitality | 2003 |
| Sean Brydon Ltd | Information & communication | 2022 |
| Sean Carrie & Co Ltd | Health & social care | 2013 |
| Sean Elliott Photography Limited | Professional & scientific | 2013 |
| Sean Watson Paving and Patios Limited | Professional & scientific | 2021 |
| Sean Wood Property Company Limited | Construction | 2017 |
| Sear Holdings Limited | Professional & scientific | 2023 |
| Search Group Recruitment Ltd | Administrative & support | 2024 |
| Search Newcastle Ltd | Professional & scientific | 2021 |
| Seaton GR SPV 13 Limited | Extraterritorial | 2017 |
| Seaton GR SPV 14 Limited | Extraterritorial | 2009 |
| Seaton Thirteen Limited | Administrative & support | 1984 |
| Seattle Lakes Bay Limited | Real estate | 1998 |
| Seaway Services LP | | 2017 |
| Seazs Cars Ltd | Transport & logistics | 2024 |
| Sebastian Investments Ltd | Real estate | 2020 |
| Sebrac Ltd | Construction | 2021 |
| SEC Access Solutions Limited | Other services | 2026 |
| SEC Fundraising Ltd | Wholesale & retail | 2014 |
| Secempire Ltd | Administrative & support | 2022 |
| Seckey Technology Ltd | Wholesale & retail | 2017 |
| Secnet Ventures Ltd | Information & communication | 2022 |
| Second Avenue (Heaton) Limited | Other services | 2015 |
| Second Language Design Consultants Ltd | Professional & scientific | 2024 |
| Secondulfo Limited | Administrative & support | 2016 |
| Secret EYE Ltd | Administrative & support | 2024 |
| Secret Indica Limited | Wholesale & retail | 2025 |
| Secret Lengths Ltd | Other services | 2019 |
| Section Data Ltd | Information & communication | 2022 |
| Sector 17 NCL Ltd | Hospitality | 2025 |
| Secure Commercial Finance Limited | Financial services | 2014 |
| Secure Gate Ltd | Manufacturing | 2020 |
| Secure Home Buyers Limited | Real estate | 2018 |