| Scott Lloyd Solutions Limited | Manufacturing | 2017 |
| Scott Luis Investments Ltd | Construction | 2023 |
| Scotts Construction NW Limited | Construction | 2017 |
| Scotts Developments NW Limited | Real estate | 2026 |
| Sdta Investments Ltd | Real estate | 2018 |
| Seddon Management Services Limited | Professional & scientific | 2014 |
| Sedr Recruitment Ltd | Administrative & support | 2018 |
| SEE the Mountain Limited | Education | 2023 |
| Self-Storage Association Limited | Other services | 1995 |
| Seligr Limited | Professional & scientific | 2022 |
| Senditlew Ltd | Professional & scientific | 2023 |
| Sensible Commercial Maintenance Ltd | Administrative & support | 2009 |
| Sensible Garden Services Ltd | Administrative & support | 2009 |
| Sentinel Risk & Resilience Consultancy Limited | Health & social care | 2021 |
| Seoh! SO Good Ltd | Information & communication | 2024 |
| Serene Studio Cheshire Ltd | Arts & recreation | 2025 |
| Serif Property Ltd | Real estate | 2022 |
| Shane Paul Investments Ltd | Real estate | 2016 |
| Shaping Governance Ltd | Professional & scientific | 2018 |
| Shapla Takeaway Ltd | Hospitality | 2021 |
| Shavington Developments Limited | Construction | 2005 |
| Shavington Rangers Football Club CIC | Arts & recreation | 2022 |
| Shawcross Commercial Properties Limited | Real estate | 2023 |
| Shawcross Properties LLP | | 2014 |
| Shaz-Crew Ltd | Real estate | 2024 |
| Shed Holdings Limited | Financial services | 2021 |
| Sheldon Vehicle Services Ltd | Wholesale & retail | 2021 |
| Sheng YAN Limited | Hospitality | 2025 |
| Shep Ventures Ltd | Construction | 2012 |
| Shield Hospitality Staffing Solutions Ltd | Administrative & support | 2021 |
| Shoes of Cheshire Limited | Wholesale & retail | 2026 |
| Shop Local (Cheshire) Ltd | Professional & scientific | 2025 |
| Shorepoint Construction Ltd | Real estate | 2025 |
| Shores Fertilisers Limited | Agriculture & fishing | 1992 |
| Show Ready Productions CIC | Arts & recreation | 2024 |
| SHS (Holdings) Limited | Financial services | 2015 |
| Shutter Speed Photography Ltd | Professional & scientific | 2024 |
| SI Belle Limited | Extraterritorial | 2006 |
| Siam Orchid Limited | Health & social care | 2013 |
| Sigma Surveys Limited | Professional & scientific | 2004 |
| Signature Property Holdings Ltd | Construction | 2019 |
| Signature Refurbs Ltd | Construction | 2019 |
| Signature Selfbuilds UK Ltd | Construction | 2019 |
| Signet (Nantwich) Limited | Construction | 2004 |
| Silk & Wild Ltd | Wholesale & retail | 2021 |
| Silver BOW Ltd | Wholesale & retail | 2018 |
| Silver Slate Films Limited | Information & communication | 2006 |
| Silverbells Landscaping Ltd | Administrative & support | 2021 |
| Silverlock Electrical Limited | Professional & scientific | 2019 |
| Silvertree Wellness Ltd | Health & social care | 2025 |
| Simbai Limited | Professional & scientific | 2020 |
| Simon Brown Properties Ltd | Real estate | 2017 |
| Simon Nixon Haulage Ltd | Transport & logistics | 2016 |
| Sinecure Limited | Wholesale & retail | 2006 |
| SIP Studio Ltd | Professional & scientific | 2018 |
| SIR Supplements Limited | Hospitality | 2024 |
| SIT Happens Buddy UP Ltd | Other services | 2024 |
| SIT Happens Dog Training Ltd | Other services | 2022 |
| SIT Happens Holding Company Ltd | Other services | 2024 |
| Site Path Training Ltd | Education | 2024 |
| SIX Towns Electrical, Fire & Security Limited | Construction | 2023 |
| SJB Marketing Limited | Professional & scientific | 2024 |
| SJB Steel Limited | Construction | 1996 |
| SJH Catering Ltd | Hospitality | 2024 |
| SK Development Consultancy Ltd | Real estate | 2025 |
| Skeet Consultancy Ltd | Professional & scientific | 2017 |
| Skip Willcocks Limited | Other services | 2009 |
| Skylight Studios Limited | Professional & scientific | 1987 |
| Slam Investment Holdings Limited | Real estate | 2021 |
| Slater Homes Commercial Ltd | Households | 2023 |
| SLD (Hatherton) Ltd | Real estate | 2018 |
| Sleeping Cat Limited | Professional & scientific | 2017 |
| Smartastudio Limited | Information & communication | 2022 |
| Smartech Service Limited | Wholesale & retail | 2018 |
| Smeaton Hall Limited | Agriculture & fishing | 2024 |
| Smeaton Wood Energy Limited | Professional & scientific | 2014 |
| Smeatonwood Management Limited | Real estate | 2005 |
| Smiths Honda Limited | Wholesale & retail | 2011 |
| SMR Social Ltd | Professional & scientific | 2017 |
| Snoozzzeee Dog Ltd | Wholesale & retail | 2018 |
| Snow Walk Properties Limited | Real estate | 1995 |
| Snug Hosting Limited | Information & communication | 2018 |
| Solar Structures Limited | Construction | 2022 |
| Solerox Limited | Wholesale & retail | 2003 |
| Solway Court Management Company Limited | Real estate | 2004 |
| Sophie Attwood Consultancy Limited | Professional & scientific | 2024 |
| Sophie Budden (Properties) Ltd | Real estate | 2018 |
| SOS Staffing Supply Ltd | Administrative & support | 2026 |
| Sotrex Holdings Limited | Financial services | 2025 |
| Sotrex Limited | Wholesale & retail | 2003 |
| Sound Fencing Ltd | Extraterritorial | 2015 |
| South African Wines Limited | Wholesale & retail | 2020 |
| South Cheshire Bookkeeping Limited | Professional & scientific | 2011 |
| South Cheshire Model Engineering Society | Arts & recreation | 1996 |
| South Cheshire Senior Care Limited | Health & social care | 2020 |
| Southampton Mobility Ltd | Wholesale & retail | 2022 |
| Sowb Limited | Real estate | 2022 |
| SP 90 NW Ltd | Construction | 2025 |
| Spa Dataworks Ltd | Information & communication | 2025 |
| Spa Propertyworks Ltd | Real estate | 2025 |