| SPD Property Group Limited | Real estate | 2023 |
| Spear Diagnostics Ltd | Public administration | 2023 |
| Specialist Access Engineering and Maintenance Association Ltd | Other services | 2017 |
| Spectrum Plus Limited | Real estate | 2015 |
| Spenny's Drinkies Ltd | Hospitality | 2024 |
| SPG Construction (Cheshire) Holdings Limited | Financial services | 2025 |
| SPG Construction (Cheshire) Ltd | Construction | 2016 |
| Spitfire @ Cheshire Green 1 Limited | Construction | 2018 |
| Spitfire @ Cheshire Green 2 Limited | Construction | 2018 |
| Spitfire Developments NW Limited | Professional & scientific | 2025 |
| Spitfire Property Agency Ltd | Professional & scientific | 2021 |
| Spitfire Property Holdings Limited | Financial services | 2021 |
| Spoke-It Ltd | Information & communication | 2018 |
| Spooner Rentals Ltd | Real estate | 2024 |
| Sppl Ltd | Hospitality | 2025 |
| Spratt Holdings Limited | Real estate | 2017 |
| Spreadwise Limited | Manufacturing | 2002 |
| Springwood Care Limited | Health & social care | 2026 |
| Squarebase Limited | Real estate | 2019 |
| Srae Property Limited | Construction | 2019 |
| ST Martha Limited | Hospitality | 2019 |
| Stacies Cars Ltd | Transport & logistics | 2023 |
| Staff Specs Ltd | Administrative & support | 2024 |
| Staffordshire ENT Clinic Limited | Health & social care | 2014 |
| Stamford Agricultural Solutions Ltd | Administrative & support | 2003 |
| Standley-Johansen Consulting Ltd | Professional & scientific | 2016 |
| Stanley Powell Limited | Administrative & support | 2011 |
| Star Learners Limited | Education | 2019 |
| Star Property Ltd | Real estate | 2021 |
| Station View Nantwich Limited | Other services | 2011 |
| Stelf Lazer Engineering Ltd | Transport & logistics | 2025 |
| Sterlingmechanicalsolutions Ltd | Construction | 2026 |
| Steven Burgin Nantwich Ltd | Administrative & support | 2016 |
| Steven Crowe Ltd | Financial services | 2025 |
| Stoane Consulting Limited | Construction | 2024 |
| Stockton Employment Services Ltd | Professional & scientific | 2026 |
| Stoke Manor Farm Industries Ltd | Wholesale & retail | 2021 |
| Strachan Developments Limited | Construction | 2004 |
| Straight Laced Limited | Information & communication | 2015 |
| Strategic HR Consultancy Solutions Limited | Administrative & support | 2025 |
| Strategy Matters Limited | Professional & scientific | 2010 |
| Strategy X Solutions Limited | Professional & scientific | 2014 |
| Stratton Design and Build Ltd | Construction | 2024 |
| Stretton (Ormskirk) Ltd | Construction | 2013 |
| Stretton Beeston Limited | Real estate | 2021 |
| Stretton Bridging Limited | Financial services | 2018 |
| Stretton Capital Limited | Financial services | 2016 |
| Stretton Denman 2 Limited | Real estate | 2006 |
| Stretton Development Finance Limited | Financial services | 2018 |
| Stretton Financial Services Limited | Financial services | 2018 |
| Stretton Milford Ltd | Construction | 2017 |
| Stretton Ramsgate Limited | Real estate | 2022 |
| Stretton Wakefield Limited | Construction | 2002 |
| Stretton Willaston Ltd | Professional & scientific | 2014 |
| Structurus Manufacturing Limited | Manufacturing | 2025 |
| Studio One Photography Limited | Professional & scientific | 2009 |
| Studio-M Design Limited | Information & communication | 2013 |
| Stylist Windows of Crewe Limited | Manufacturing | 2010 |
| Subirats-Knowles Ltd | Health & social care | 2023 |
| Suddenstrike Drain Care Limited | Extraterritorial | 2024 |
| Suddenstrike Fencing Limited | Extraterritorial | 2024 |
| Suddenstrike Limited | Administrative & support | 1997 |
| Suddenstrike Pest Control Limited | Administrative & support | 2017 |
| Summer Hill Boarding Kennels Limited | Hospitality | 2003 |
| Sun Sing Ltd | Hospitality | 2021 |
| Sunday Bloom Limited | Wholesale & retail | 2026 |
| Sunday House Interiors Ltd | Professional & scientific | 2026 |
| Sundowner Investments Limited | Wholesale & retail | 2018 |
| Sunflowers at St.Anne's | Education | 2008 |
| Sunrock Balconies & Balustrades Limited | Construction | 2018 |
| Sunsoul Ltd | Wholesale & retail | 2018 |
| Super Natural Baits Limited | Wholesale & retail | 2025 |
| Supplier Mode Ltd | Wholesale & retail | 2025 |
| Supply Chain Efficiency Limited | Professional & scientific | 2006 |
| Suredwell Ltd | Real estate | 2018 |
| Surefire Media Ltd | Information & communication | 2008 |
| Sureview Ultrasound Ltd | Health & social care | 2023 |
| Swan Petroleum Limited | Extraterritorial | 1965 |
| Swanley Bridge Marina Ltd | Other services | 2005 |
| Swanley Holdings Limited | Financial services | 2025 |
| Swanlow Properties Limited | Real estate | 2022 |
| Sweetfuels Limited | Wholesale & retail | 2005 |
| Switch Onto Savings Ltd | Professional & scientific | 2019 |
| Sykes Electrical Solutions Ltd | Construction | 2025 |
| Symu Ltd | Information & communication | 2025 |
| T Martin Ltd | Health & social care | 2014 |
| T'S Pizza Parlour Ltd | Hospitality | 2024 |
| T5 Training Solutions Ltd | Professional & scientific | 2025 |
| Tadgedale Quarry Restoration Limited | Professional & scientific | 2002 |
| TAG Design Limited | Professional & scientific | 2003 |
| Tag.W Holdings Ltd | Real estate | 2024 |
| Tahnee & Ross Lettings Ltd | Real estate | 2023 |
| Tala Endeavours Limited | Real estate | 2021 |
| Talent Designs Ltd | Administrative & support | 2006 |
| Talent Inspire Limited | Professional & scientific | 2014 |
| Tamworth Multi Sports Club Ltd | Education | 2026 |
| Tandy Health and Fitness Ltd | Other services | 2025 |
| Tapestry Properties Limited | Real estate | 2018 |
| Tarvin Community Woodland Trust Limited | Agriculture & fishing | 2014 |
| Tate House Buyers Limited | Real estate | 2019 |