| Sakem Home and Garden Glow Ltd | Construction | 2025 |
| Saki’S Ghanaian Oriented Foods Ltd | Hospitality | 2025 |
| Saks Auto World Ltd | Wholesale & retail | 2021 |
| Sakura Consultants Limited | Information & communication | 2015 |
| Sakura Emerald Limited | Hospitality | 2022 |
| Sala MK Ltd | Arts & recreation | 2025 |
| Sala.Uk Limited | Wholesale & retail | 2007 |
| Salad Ville UK Ltd | Agriculture & fishing | 2024 |
| Salamander-Phoenix Limited | Information & communication | 2015 |
| Salden Place (Varsity Way Apartments) Residents Management Company Limited | Households | 2026 |
| Salden Place Residents Management Company Limited | Households | 2025 |
| Sale LAB Limited | Wholesale & retail | 2020 |
| Salej Ltd | Construction | 2016 |
| Saleos Infrastructure Ltd | Real estate | 2024 |
| Saleostech Limited | Information & communication | 2023 |
| Sales Consulting Ltd | Information & communication | 2023 |
| Sales Positioning Ltd | Professional & scientific | 2016 |
| SALES4U2 Ltd | Wholesale & retail | 2025 |
| Salih Driving School Limited | Education | 2025 |
| Salineflow Ltd | Other services | 2024 |
| Salix Ventures Limited | Real estate | 2010 |
| Salker Solutions Limited | Health & social care | 2026 |
| Sally Wood Consultancy Limited | Professional & scientific | 2019 |
| SALLYRAJ100 Limited | Health & social care | 2014 |
| Salma Nasir (Smc-Private) Limited | Wholesale & retail | 2025 |
| Salmon M&E Ltd | Construction | 2018 |
| Salon Equipment Services Limited | Wholesale & retail | 2024 |
| Salt Clinic MK Limited | Health & social care | 2011 |
| Salt Cybersecurity Ltd | Information & communication | 2019 |
| Salt Hospitality Limited | Hospitality | 2016 |
| Salt Shack Ltd | Wholesale & retail | 2021 |
| Salu Web Ltd | Wholesale & retail | 2025 |
| Salvage IT Limited | Wholesale & retail | 2000 |
| Salve Regina Properties Ltd | Real estate | 2025 |
| SAM Aiks Limited | Wholesale & retail | 2020 |
| SAM Developers Ltd | Construction | 2008 |
| SAM Drives Ltd | Education | 2026 |
| SAM Gilbey Limited | Information & communication | 2008 |
| SAM Truck Ltd | Wholesale & retail | 2020 |
| SAM Warehouse Ltd | Real estate | 2025 |
| Sam&K Srevices Limited | Administrative & support | 2025 |
| SAM40 Transport Limited | Transport & logistics | 2018 |
| Samadi Properties Ltd | Real estate | 2021 |
| Samanvi Consulting Ltd | Information & communication | 2021 |
| Samanvi Info Ltd | Information & communication | 2015 |
| Samara House Limited | Real estate | 2025 |
| Samarke Properties Limited | Real estate | 2011 |
| Samasy Ltd | Other services | 2024 |
| Samay Fashions Ltd | Wholesale & retail | 2024 |
| Samb FM Solutions Ltd | Other services | 2015 |
| Samba Sports Coaching Limited | Arts & recreation | 2017 |
| Sambacreations Ltd | Wholesale & retail | 2020 |
| Sambecs Limited | Education | 2016 |
| Samclo Limited | Construction | 2012 |
| Same Sime Technologies Ltd | Professional & scientific | 2011 |
| Samersault Ltd | Professional & scientific | 2014 |
| Sameva Asset Management Ltd | Extraterritorial | 2021 |
| Samika Consultancy Ltd | Information & communication | 2018 |
| Samiu Limited | Health & social care | 2019 |
| Sammm Limited | Transport & logistics | 2021 |
| Sammons Consultancy Services Limited | Professional & scientific | 2008 |
| Sammy Gardening Services Ltd | Administrative & support | 2024 |
| Sammy's Shoes Ltd | Wholesale & retail | 2014 |
| Sammyphyl Services Ltd | Wholesale & retail | 2019 |
| Sampad (UK) Ltd | Real estate | 2022 |
| Samraj-Brown Limited | Wholesale & retail | 2025 |
| Samrose Professionals Limited | Health & social care | 2014 |
| Samry Ltd | Construction | 2024 |
| SAMS4SAMS Investment Ltd | Professional & scientific | 2013 |
| Samson Roofing Limited | Construction | 2003 |
| Samson Trading Company Limited | Administrative & support | 1995 |
| Samtam Limited | Health & social care | 2013 |
| Samtechgns Limited | Information & communication | 2022 |
| Samuel Akanmu Limited | Information & communication | 2014 |
| Samuel Brookes Limited | Financial services | 2016 |
| Samuel Brookes Mining Consortium Private Limited | Wholesale & retail | 2018 |
| Samuel J Chandler Ltd | Professional & scientific | 2015 |
| Samuel Luica Transport Ltd | Transport & logistics | 2021 |
| Samuels Close (Road Holdings) Ltd | Other services | 2025 |
| Samuels Holdings Ltd | Financial services | 2026 |
| Samurai Apparel Limited | Manufacturing | 2020 |
| Samy 786 Ltd | Wholesale & retail | 2024 |
| SAN Miniato Ltd | Information & communication | 2018 |
| Sanbero Ltd | Construction | 2023 |
| Sanchez Talent Ltd | Information & communication | 2016 |
| Sancho Properties Limited | Real estate | 2006 |
| Sanda Ionescu Ltd | Health & social care | 2023 |
| Sandbergh Ltd | Real estate | 2023 |
| Sandels Developments Limited | Construction | 2004 |
| Sanderstock LLP | | 2019 |
| Sandhas Catering Ltd | Hospitality | 2015 |
| Sandhata Property One Limited | Real estate | 2015 |
| Sandhill Consulting Limited | Professional & scientific | 2023 |
| Sandhill Plant Limited | Wholesale & retail | 2013 |
| Sandhills Publishing Limited | Information & communication | 2009 |
| Sandhu MK Properties Ltd | Real estate | 2024 |
| Sandjunes Holiday Chalets Ltd | Hospitality | 2022 |
| Sandlight Travels Ltd | Administrative & support | 2025 |
| Sandor's Artisan Ltd. | Wholesale & retail | 2015 |
| Sandra Ltd | Transport & logistics | 2017 |