| Elwell Industries Ltd | Professional & scientific | 2024 |
| Elysium Skin and Holistics Ltd | Other services | 2025 |
| Emad Cars Limited | Wholesale & retail | 2025 |
| Emanade Limited | Health & social care | 2025 |
| Emanuel Cleaning Ltd | Administrative & support | 2025 |
| Emanuel Marin Logistics Limited | Transport & logistics | 2025 |
| Embrace Excellence Limited | Wholesale & retail | 2019 |
| Emerald Sustainable Consulting Limited | Professional & scientific | 2021 |
| Emerson Advisers Limited | Professional & scientific | 2024 |
| EMH Capital Limited | Financial services | 2025 |
| EMH Plant Ltd | Wholesale & retail | 2024 |
| Eminent Technical Services (North East ) Limited | Professional & scientific | 2011 |
| Emjays Wholesale Ltd | Wholesale & retail | 2019 |
| Emmajid Ventures Limited | Construction | 2016 |
| Emmersons Show Team LLP | | 2012 |
| Emmeto Ltd | Health & social care | 2019 |
| Emmokmac Ltd | Professional & scientific | 2025 |
| EMN Rigging & Lifting Services Limited | Construction | 2017 |
| Empire Roofline Ltd | Construction | 2026 |
| EMPIRE40 Ltd | Information & communication | 2022 |
| Emporium Aesthetics and Beauty Ltd | Other services | 2023 |
| Emporium Chauffeur Service Ltd | Transport & logistics | 2026 |
| Emporium Properties Ltd | Real estate | 2020 |
| Empowerme Occupational Therapy Practice CIC | Education | 2026 |
| Emzotech Ltd | Professional & scientific | 2016 |
| Emzotech North Ltd | Professional & scientific | 2026 |
| Encore Educational Ltd | Wholesale & retail | 2024 |
| Endeavour 160 Limited | Real estate | 2023 |
| Endeavour Academies Trust | Education | 1988 |
| Endeavour Home Improvements and Insulation Specialists Ltd | Construction | 2026 |
| Endeavour IT Services (UK) Limited | Information & communication | 2012 |
| Endeavour Leisure Group Limited | Arts & recreation | 2017 |
| Endeavour Windows and Home Improvements Limited | Construction | 2017 |
| Endunamoó Limited | Education | 2022 |
| Enelect Ltd | Other services | 2024 |
| Energe Developments Ltd | Real estate | 2023 |
| Energy Clothing Limited | Wholesale & retail | 2002 |
| Energy Pro Consultants Limited | Professional & scientific | 2026 |
| Enforcement Bailiffs Ltd | Other services | 2009 |
| Engineering Inspection Services (NE) Ltd | Professional & scientific | 2013 |
| Engineering Recruitment Services Ltd | Manufacturing | 2006 |
| Engineering Resource & Support Ltd | Other services | 2018 |
| Enhance Aesthetics Group Limited | Other services | 2025 |
| Enhance Personal Training Ltd | Professional & scientific | 2023 |
| Enhance Project Services Ltd | Professional & scientific | 2020 |
| Enhance Property Services Ltd | Real estate | 2025 |
| Enhanced Appearance Ltd | Other services | 2024 |
| Enhanced Development Solutions Ltd | Construction | 2025 |
| Eniscare Limited | Health & social care | 2024 |
| Enlighten Leadership Limited | Professional & scientific | 2023 |
| Enterprise Made Simple Ltd | Administrative & support | 2008 |
| Enterprise Revolution CIC | Administrative & support | 2010 |
| Enterprise Security Services Limited | Administrative & support | 2003 |
| Enterprise Surgery Ltd | Health & social care | 2015 |
| Enviro Electrical Engineering Ltd | Manufacturing | 2023 |
| Enviro Mechanical Engineering Ltd | Professional & scientific | 2024 |
| Envirogreen Engineering Ltd | Professional & scientific | 2021 |
| Environmental Alternatives Limited | Professional & scientific | 2002 |
| EOL Properties Ltd | Real estate | 2014 |
| EOS Devco Limited | Construction | 2016 |
| EP Property Maintenance Ltd | Construction | 2025 |
| EPD Print Limited | Manufacturing | 2022 |
| EPH Engineering Ltd | Construction | 2021 |
| Epic Reach Global Services Limited | Hospitality | 2024 |
| Eposrus North East Ltd | Wholesale & retail | 2025 |
| Epow Limited | Energy | 2026 |
| Equal Alignment Clinic Limited | Health & social care | 2019 |
| Equinox 110 Ltd | Transport & logistics | 2013 |
| Equinox Direct Ltd | Wholesale & retail | 2026 |
| Equipment Supplies & Consultancy Services Limited | Manufacturing | 2012 |
| Equipment Supplies Consultancy Services & Pipe Coating Systems Ltd | Manufacturing | 2017 |
| ERA Property North East Ltd | Real estate | 2026 |
| Erase Aesthetics Ltd | Other services | 2015 |
| ERC Commercial Ltd | Real estate | 2021 |
| ERH Rigging Services Ltd | Construction | 2021 |
| Eric Carter Car Sales Limited | Wholesale & retail | 2000 |
| Erik&Andreea Limited | Manufacturing | 2019 |
| Erimus Electrical Limited | Construction | 2005 |
| Erimus Lettings Ltd | Real estate | 2018 |
| Erimus Rising Ltd | Information & communication | 2020 |
| Erimus Safety Ltd | Public administration | 2023 |
| Erimus Securities Limited | Financial services | 1961 |
| Erimus Security Services Limited | Administrative & support | 2022 |
| Erni's Bakery and Foods Limited | Manufacturing | 2025 |
| ERP1 Ltd | Real estate | 2025 |
| Erriapus Ltd | Professional & scientific | 2022 |
| Erskin Watts Limited | Administrative & support | 2012 |
| Ersoz Ltd | Wholesale & retail | 2016 |
| Ersöz Estates Ltd | Real estate | 2018 |
| ERW Group Limited | Financial services | 2021 |
| ERW Joinery Limited | Manufacturing | 2009 |
| ERW Specialist Products Ltd | Construction | 2023 |
| ES Richardson Ltd | Construction | 2024 |
| ESA Investment M Ltd | Real estate | 2026 |
| Escs Training & Recruitment Ltd | Other services | 2020 |
| Eshark Global Ltd | Administrative & support | 2026 |
| Eshpro Holdings Ltd | Real estate | 2022 |
| ESK Close Pizzeria Ltd | Hospitality | 2022 |
| ESK Valley Shamanic Arts Ltd | Other services | 2026 |
| Eskad Limited | Real estate | 2018 |