| Eskdale Catering Limited | Hospitality | 2014 |
| ESP Renewables UK Ltd | Professional & scientific | 2022 |
| Essential Import Ltd | Wholesale & retail | 2024 |
| Estate Business Limited | Real estate | 2023 |
| Estate Planning Made Easy Ltd | Other services | 2021 |
| Eston Autos Limited | Wholesale & retail | 2003 |
| Eston Barbers Limited | Other services | 2025 |
| Eston Discount DIY Ltd | Wholesale & retail | 2022 |
| Eston Glass Ltd | Construction | 2015 |
| Eston Investments Ltd | Construction | 2025 |
| Eston Nails and Beauty Limited | Other services | 2025 |
| Eston Project Support Limited | Professional & scientific | 2026 |
| Eston Service Station Limited | Wholesale & retail | 2016 |
| Eston Shop Ltd | Wholesale & retail | 2025 |
| Eston Social Club Limited | Hospitality | 2023 |
| Eston Spice Limited | Hospitality | 2026 |
| Esvu Constructions Ltd | Construction | 2025 |
| Esync Deep Ltd | Information & communication | 2025 |
| Ethan Fades Ltd | Other services | 2023 |
| Ethan Sandhu Limited | Health & social care | 2016 |
| Ethereal Real Estate Ltd | Real estate | 2024 |
| Etier Ltd | Wholesale & retail | 2022 |
| Eurasia Fashions Ltd | Wholesale & retail | 2023 |
| Euro Food Traditional Romanesc Ltd | Wholesale & retail | 2023 |
| Euro Market Beaumont Ltd | Wholesale & retail | 2025 |
| Euro Qa/Qc Reps Ltd | Construction | 2023 |
| Eurovent Hvac Solutions Ltd | Administrative & support | 2019 |
| EVA Risk Limited | Construction | 2024 |
| Evans & Harvey Property Ltd | Real estate | 2023 |
| Evans Housing Ltd | Real estate | 2023 |
| Evening Drink Ltd | Wholesale & retail | 2022 |
| Event Attractions (NE) Limited | Arts & recreation | 2018 |
| Eventasap Ltd | Information & communication | 2023 |
| Events by Vogue Ltd | Administrative & support | 2023 |
| Everleys Dreams Ltd | Hospitality | 2024 |
| Everline Property Solutions Ltd | Construction | 2024 |
| Evershed Investments Limited | Financial services | 2025 |
| Everstone Capital Ltd | Wholesale & retail | 2025 |
| Everstone Property Group Ltd | Real estate | 2026 |
| Every Child Studios CIC | Health & social care | 2025 |
| Everyday Apartment Ltd | Construction | 2022 |
| Everyday Essentials 2026 Ltd | Wholesale & retail | 2026 |
| Everything Charis Limited | Wholesale & retail | 2026 |
| Evils Ltd | Arts & recreation | 2022 |
| Evne Ltd | Construction | 2025 |
| Evolution Alloys Ltd | Wholesale & retail | 2018 |
| Evolution Coaching (NE) Limited | Arts & recreation | 2021 |
| Evolution Estates NE Ltd | Real estate | 2022 |
| Evolution Health & Fitness (NE) Limited | Arts & recreation | 2015 |
| Evolve Building Control Consultants Ltd | Professional & scientific | 2013 |
| Evolve Case Management Ltd | Health & social care | 2021 |
| Evolve Education & Sports Management Ltd | Administrative & support | 2025 |
| Evolve Financial NE Ltd | Financial services | 2014 |
| Evolve in the Community CIC | Education | 2025 |
| Evolve Sports Academy Ltd | Education | 2017 |
| Evron Networks Limited | Information & communication | 2025 |
| EW Wheeldon Logistics Ltd | Transport & logistics | 2025 |
| EX Electroservices Ltd | Construction | 2016 |
| EX Motors Ltd | Wholesale & retail | 2018 |
| Exact & Co UK Ltd | Real estate | 2025 |
| Excel Consultant and Services Ltd | Information & communication | 2024 |
| Exceptional Trade Ltd | Wholesale & retail | 2017 |
| Excore North East Limited | Construction | 2009 |
| Executive Parking Services Ltd | Transport & logistics | 2018 |
| Exotic Global Trading Ltd | Wholesale & retail | 2016 |
| Expert Plumbing Limited | Construction | 2020 |
| Explore Mobility Vehicles Ltd | Wholesale & retail | 2015 |
| Express Decorator Ltd | Construction | 2022 |
| Express Nails Limited | Health & social care | 2014 |
| Express Transportation (NE) Ltd | Transport & logistics | 2025 |
| EXT Consultants Ltd | Wholesale & retail | 2021 |
| Extended Roots Ltd | Information & communication | 2020 |
| Exterior Facade Design Limited | Construction | 2005 |
| Extra Mile Tyres Ltd | Wholesale & retail | 2025 |
| EYE Phone NE Limited | Wholesale & retail | 2023 |
| F & a Cleaning Ltd | Administrative & support | 2022 |
| F&S Beauty World Ltd | Wholesale & retail | 2024 |
| F-Teebabs Properties Ltd | Real estate | 2024 |
| F. Ussa Ltd | Health & social care | 2023 |
| F.J Walker Ltd | Other services | 2025 |
| F24 Online Ltd | Wholesale & retail | 2021 |
| Fabi Trans Ltd | Transport & logistics | 2025 |
| Fabian Cleaning Ltd | Administrative & support | 2016 |
| Fabmatic Ltd | Professional & scientific | 2024 |
| Fabrication and Access Ltd | Construction | 2026 |
| Face 2 Face Solutions Limited | Professional & scientific | 2003 |
| Fadashe Limited | Wholesale & retail | 2025 |
| Faheem Properties Ltd | Real estate | 2025 |
| Fahreen Contracting Limited | Professional & scientific | 2019 |
| Faiq Baloch Ltd | Wholesale & retail | 2025 |
| Fairfield Auctions Limited | Wholesale & retail | 1986 |
| Fairfield Industries Limited | Wholesale & retail | 1987 |
| Fairsound Ltd | Information & communication | 2021 |
| Fairtrade Media Ltd | Professional & scientific | 2024 |
| Fairwold Limited | Real estate | 2018 |
| Faithy Fittings Limited | Manufacturing | 2025 |
| Falcon Design Services Limited | Information & communication | 2018 |
| Falcon Engineering & Development Limited | Wholesale & retail | 1990 |
| Falcon Performance UK Limited | Manufacturing | 2008 |
| Falcon Prestige Sales & Motorsports Ltd | Extraterritorial | 2011 |