| Daizy Babies Ltd | Wholesale & retail | 2010 |
| Dales Doctors Limited | Health & social care | 2022 |
| Dali Cottages Ltd | Real estate | 2021 |
| Dalton Law Limited | Professional & scientific | 2006 |
| Damian Matthews Limited | Transport & logistics | 2007 |
| DAN James Autos Ltd | Wholesale & retail | 2025 |
| DAN Punchard Limited | Transport & logistics | 2004 |
| DAN Sheldon Plant Hire Ltd | Administrative & support | 2014 |
| DAN Wilson Studio Ltd | Professional & scientific | 2019 |
| Daniels Associates F S Limited | Hospitality | 2023 |
| Daodejing Ltd | Hospitality | 2026 |
| Darley Convenience Ltd | Wholesale & retail | 2024 |
| Darley Dale Fish Bar Ltd | Hospitality | 2025 |
| Darley Dale Garage Limited | Wholesale & retail | 2022 |
| Darley Dale Takeaway Ltd | Hospitality | 2023 |
| Darley Tax Ltd | Professional & scientific | 2023 |
| Darwell Roofing Limited | Construction | 2019 |
| David Fairey Ltd | Wholesale & retail | 2018 |
| David Hopgood Limited | Transport & logistics | 2013 |
| David Tomlinson Motor Factors Limited | Wholesale & retail | 2003 |
| David Wetton Marketing Limited | Wholesale & retail | 2016 |
| DBS Automotives Limited | Wholesale & retail | 2017 |
| DBS Plant Hire Limited | Construction | 2009 |
| DE43 Developments Ltd | Construction | 2017 |
| Death and Disease Limited | Financial services | 2008 |
| Deception Escape Rooms Ltd | Arts & recreation | 2017 |
| DEE - Scan Limited | Manufacturing | 1991 |
| Deecee (UK) Limited | Real estate | 1998 |
| DEFIB4LIFE Ltd | Other services | 2019 |
| Delcor Ltd. | Manufacturing | 2009 |
| Delft Projects Limited | Administrative & support | 2010 |
| Dennys Creek (J.C.O.) Limited | Hospitality | 1991 |
| Derbyco Project SPV Limited | Water & waste | 2019 |
| Derbyshire Canine Services Ltd | Professional & scientific | 2020 |
| Derbyshire Carnivorous Plants Ltd | Wholesale & retail | 2024 |
| Derbyshire Catering Group Ltd | Hospitality | 2019 |
| Derbyshire Dales Electrical Services Limited | Construction | 2010 |
| Derbyshire Dales Primary Care Network Ltd | Health & social care | 2022 |
| Derbyshire Dales System Engineering Ltd | Information & communication | 2014 |
| Derbyshire Eco Centre CIC | Education | 2026 |
| Derbyshire Ecologist Ltd | Professional & scientific | 2022 |
| Derbyshire Fluor Spa Company Limited | Extraterritorial | 1913 |
| Derbyshire Historical Lead Mines Limited | Professional & scientific | 1970 |
| Derbyshire Home Care Services Limited | Health & social care | 2023 |
| Derbyshire Legal Services (Property) Limited | Real estate | 2021 |
| Derbyshire Legal Services Limited | Professional & scientific | 2014 |
| Derbyshire Pet Stores Limited | Wholesale & retail | 2026 |
| Derbyshire Plumbing and Heating Services Ltd | Construction | 2014 |
| Derbyshire Psychology Limited | Health & social care | 2017 |
| Derbyshire Wholesale Limited | Wholesale & retail | 2016 |
| Derbyshire Wildlife Resources Limited | Professional & scientific | 1988 |
| Derbyshire Wildlife Trust Limited | Other services | 1962 |
| Dervishi Fast Food Ltd | Hospitality | 2019 |
| Derwent Financial Services Limited | Financial services | 2003 |
| Derwent Lettings Ltd | Real estate | 2020 |
| Derwent Treescapes Limited | Administrative & support | 1990 |
| Derwent Valley Tours Ltd | Arts & recreation | 2019 |
| Derwent Valley Vets Limited | Professional & scientific | 2015 |
| Designate @ the Gate Ltd | Hospitality | 2012 |
| DH Rose Cottage Ltd | Hospitality | 2024 |
| Diamond Luxe Nails Ltd | Other services | 2026 |
| Diamond Nails HH Ltd | Other services | 2023 |
| Dickiedido Limited | Construction | 2026 |
| Digital Accessories Limited | Wholesale & retail | 2009 |
| Digital Peaks Technology Limited | Information & communication | 2016 |
| Dirty Devil Limited | Wholesale & retail | 2014 |
| Disasterman Limited | Information & communication | 2000 |
| Disco Bar Congleton Ltd | Hospitality | 2019 |
| Disco Bar Leek Ltd | Hospitality | 2017 |
| Discover Travel Limited | Administrative & support | 2024 |
| Discovery Brands Limited | Wholesale & retail | 1999 |
| DKT Consultants Ltd | Professional & scientific | 2015 |
| DLO Consulting Limited | Professional & scientific | 2012 |
| DMB Mortgage Expert Ltd | Financial services | 2017 |
| DMC Commercial Consultancy Ltd | Information & communication | 2023 |
| Dockshack Seafood Limited | Hospitality | 2021 |
| Don'T Ever Ring the Bell Limited | Arts & recreation | 2016 |
| Double L Games Limited | Arts & recreation | 2017 |
| Doubles Ltd | Real estate | 2017 |
| Doughnuts & Ice Cream Ltd | Hospitality | 2021 |
| DPB Developments Limited | Construction | 2008 |
| Dragonfly Kitchens Limited | Wholesale & retail | 2014 |
| DRF Consultants Limited | Professional & scientific | 2016 |
| DRF Developments Limited | Real estate | 2018 |
| Driftwood Capital Finance I Ltd | Real estate | 2025 |
| Driftwood Capital Finance II Ltd | Real estate | 2025 |
| Driftwood Capital Finance Limited | Real estate | 2025 |
| Driftwood Capital Limited | Construction | 2015 |
| DS Performance Sport Ltd | Arts & recreation | 2023 |
| DT Property Holdings Limited | Real estate | 2026 |
| Dtc&M Ltd | Manufacturing | 2018 |
| Dubrek Studios Limited | Extraterritorial | 2021 |
| Dukes Barn Company | Education | 2000 |
| Duncan Whittam Limited | Professional & scientific | 2015 |
| Dvision One Ltd. | Professional & scientific | 2016 |
| DYI Ltd | Construction | 2022 |
| Dylan Wakefield Legacy Holdings Limited | Financial services | 2025 |
| Dynolix Ltd | Information & communication | 2025 |
| Dyrek Ltd | Manufacturing | 2026 |
| E S C Builders Limited | Construction | 2015 |