| CB Travel Ltd | Administrative & support | 2021 |
| CC Motorsport Limited | Wholesale & retail | 2018 |
| CE Bridal Outlet Limited | Wholesale & retail | 2026 |
| Central MEP Ltd | Construction | 2019 |
| Centron Limited | Information & communication | 1989 |
| Cereals Fruit Focus (UK) Limited | Administrative & support | 2021 |
| CGK Property Limited | Real estate | 2025 |
| Champion Water Compliance Limited | Water & waste | 2015 |
| Chantrey House Property Services Ltd | Real estate | 2013 |
| Charian Properties Ltd | Real estate | 2012 |
| Charles Gregory & Sons (Timber) Limited | Manufacturing | 1960 |
| Charlotte Elizabeth Bridal Ltd | Wholesale & retail | 2020 |
| Chatsworth Media Ltd | Professional & scientific | 2019 |
| Chester's Construction & Development Ltd | Construction | 2025 |
| Chico Barber Ltd | Other services | 2019 |
| Chloe Ashby Hair Artist Limited | Other services | 2024 |
| Chocolat Matlock Limited | Wholesale & retail | 2025 |
| Christian Youth Foundation Limited | Hospitality | 1988 |
| Churchtown Trading Limited | Wholesale & retail | 2018 |
| Ciag Property Investments Ltd | Real estate | 2021 |
| Circles LS Ltd | Professional & scientific | 2019 |
| Circulation Design Consultancy Limited | Professional & scientific | 2005 |
| Circus Strong CIC | Arts & recreation | 2021 |
| Cirrus Engineering Design Limited | Professional & scientific | 1998 |
| Cito UK & European Transport Ltd | Transport & logistics | 2017 |
| Classical CD Limited | Wholesale & retail | 1993 |
| Clayton Barker Retail Ltd | Wholesale & retail | 2021 |
| Clayton Property Investment Holdings Ltd | Real estate | 2014 |
| Clear Brew (Chesterfield) Limited | Administrative & support | 2018 |
| Closed Door Consultancy Ltd | Professional & scientific | 2025 |
| CMW Skin Ltd | Wholesale & retail | 2026 |
| Cnekt Ltd | Professional & scientific | 2025 |
| Coastwood Fabrication Ltd | Professional & scientific | 2017 |
| Coates Family Butchers Ltd | Wholesale & retail | 2017 |
| Collina Holdings (Warrington) Limited | Construction | 2019 |
| Collins Education Associates Ltd | Professional & scientific | 2019 |
| Colocheck Ltd. | Health & social care | 2014 |
| Colombo Tansley Limited | Hospitality | 2019 |
| Colour Connections Consultancy Limited | Professional & scientific | 2007 |
| Combined Protection & Training (CPT) Ltd | Administrative & support | 2025 |
| Commando Temple Peak District Limited | Arts & recreation | 2024 |
| Commercial Property Real Estates Limited | Real estate | 2013 |
| Community Fayre CIC | Information & communication | 2024 |
| Compass HR Consulting Ltd | Administrative & support | 2006 |
| Composite Tooling & Engineering Solutions Ltd | Manufacturing | 2013 |
| Conscious Meraki Ltd | Professional & scientific | 2025 |
| Consilium Group Limited | Administrative & support | 2001 |
| Construction Steelwork Ltd | Manufacturing | 2026 |
| Contours Holdings Limited | Financial services | 2019 |
| Contours Walking Holidays Limited | Administrative & support | 2003 |
| Cool River Cafe Ltd. | Hospitality | 2013 |
| Corker Holdings Ltd | Real estate | 2023 |
| Cosmic Human Operating Model Ltd | Information & communication | 2026 |
| Cottage & Cabin Holidays Limited | Hospitality | 2025 |
| Cottage Management Services in the Peaks Ltd | Real estate | 2011 |
| Counting King Limited | Professional & scientific | 2020 |
| County GY Ltd | Hospitality | 2018 |
| Coverly Sisters & Co. Ltd | Wholesale & retail | 2024 |
| CPP Waste & Recycling Limited | Water & waste | 2009 |
| Cqual Limited | Professional & scientific | 2012 |
| Crafted Cycles Limited | Manufacturing | 2025 |
| Creating Places (Derbyshire) Ltd | Construction | 2017 |
| Credas Medical Ltd | Health & social care | 2019 |
| Crich Butchers Limited | Wholesale & retail | 2010 |
| Crich Investments Ltd | Real estate | 2025 |
| Crimson Cat Limited | Professional & scientific | 2006 |
| Critical Electrical Services Limited | Construction | 2024 |
| Crocodile House Limited | Information & communication | 2002 |
| Cromford Garage Limited | Wholesale & retail | 2024 |
| Cromford Group Limited | Real estate | 1928 |
| Cromford Hospitality Ltd | Hospitality | 2026 |
| Cromford Mill Limited | Wholesale & retail | 1994 |
| Cromford Water Power Community Interest Company | Energy | 2022 |
| Crosstower Ventures Limited | Real estate | 2000 |
| Crown Enterprises Ltd | Hospitality | 2016 |
| Crown Nails Bar Limited | Other services | 2020 |
| Crown Square Transport and Removals Ltd | Transport & logistics | 2020 |
| CS Services Wirksworth Ltd | Transport & logistics | 2008 |
| Curated Menu Software Ltd | Information & communication | 2025 |
| Curiousa Ltd | Manufacturing | 2012 |
| Curtis Lettings & Property Management Limited | Real estate | 2022 |
| Curtis Lettings Ltd | Real estate | 2020 |
| Curtis Property Management Limited | Real estate | 2020 |
| Curtis Security Limited | Administrative & support | 2026 |
| Curve Insight Limited | Professional & scientific | 2017 |
| Curveball Limited | Real estate | 2026 |
| Custodia Continuity Ltd | Information & communication | 2019 |
| Custom Escapes Limited | Extraterritorial | 2024 |
| CW Estates Ashbourne Ltd | Real estate | 2024 |
| CW Estates Limited | Real estate | 2017 |
| CW Estates SA Limited | Real estate | 2021 |
| CWG Property Limited | Hospitality | 2023 |
| Cyclo Trust | Arts & recreation | 2011 |
| D & S Properties Limited | Real estate | 2000 |
| D Williams Limited | Hospitality | 2004 |
| D.L.S. (UK) Limited | Wholesale & retail | 1998 |
| D.T. Engineering Limited | Agriculture & fishing | 2001 |
| Daedal Management Limited | Real estate | 2016 |
| Daisy Veterinary Care Services Ltd | Professional & scientific | 2023 |
| Daisychain Homecare Services (Bakewell) Limited | Health & social care | 2013 |