| Sciterion Limited | Professional & scientific | 2006 |
| SCJ Engineering Limited | Professional & scientific | 2022 |
| SCL Accounting Limited | Professional & scientific | 2013 |
| SCL Properties Limited | Construction | 2017 |
| SCL STR Limited | Wholesale & retail | 2018 |
| SCM CEP Limited | Manufacturing | 2021 |
| Scope Teaching Limited | Education | 2019 |
| SCOPE3 Data Ltd | Information & communication | 2022 |
| Scoppa Shop Ltd | Wholesale & retail | 2025 |
| Scopten Ltd | Construction | 2013 |
| Scotney Projects Limited | Extraterritorial | 2016 |
| Scott Barr Homes Limited | Real estate | 2006 |
| Scott Grant Carpets Limited | Wholesale & retail | 2015 |
| Scott Harrington Reynolds | Extraterritorial | 2024 |
| Scott Hawkins Property Limited | Real estate | 2015 |
| Scott Osteopathic & Health Clinic Ltd | Health & social care | 2021 |
| Scott Taylor Automotive Solutions Ltd | Wholesale & retail | 2023 |
| Scout Solutions Limited | Information & communication | 2015 |
| SCR Construction Ltd | Manufacturing | 2024 |
| Screenlab Limited | Information & communication | 2014 |
| Scs-Cleaning(South East) Ltd. | Administrative & support | 2018 |
| Scuffs NO More Limited | Administrative & support | 2008 |
| SCZ Carpentry Ltd | Construction | 2022 |
| SD Connect Limited | Professional & scientific | 2012 |
| SD Construction Kent Limited | Extraterritorial | 2012 |
| SD Law Ltd | Professional & scientific | 2019 |
| SDA (Property Investments) Limited | Real estate | 2016 |
| Sdar Limited | Professional & scientific | 2018 |
| SDH Holdco Limited | Information & communication | 2012 |
| SE Club Nights Ltd | Arts & recreation | 2021 |
| Sea Dragon Design Ltd | Information & communication | 2015 |
| Seafood by Design Ltd | Education | 2022 |
| Sealpro Automotive Limited | Manufacturing | 2024 |
| Sean Curtin Consultancy Limited | Construction | 2026 |
| Sean Ratcliffe Tuning Ltd | Wholesale & retail | 2021 |
| Seapack Limited | Administrative & support | 2025 |
| Searle Installations Ltd | Administrative & support | 2006 |
| Seasight Davits UK Ltd | Construction | 2018 |
| Seasons of Kent Ltd | Other services | 2014 |
| SEC Construction Group Limited | Professional & scientific | 2021 |
| Second Ancells (Fleet) Management Company Limited | Real estate | 1987 |
| Second Huntbourne Management Company Limited | Real estate | 1964 |
| Second Run Limited | Information & communication | 2004 |
| Second Solution Ltd | Transport & logistics | 2025 |
| Secretarial & Administration Services Limited | Administrative & support | 1998 |
| Secure Solar Ltd | Construction | 2024 |
| Secure Tech Systems Limited | Administrative & support | 2022 |
| Secureconnect Ltd | Information & communication | 2025 |
| Securitatem Consultancy Limited | Administrative & support | 2016 |
| Securitatem Group Limited | Administrative & support | 2019 |
| Securitatem Installations Limited | Administrative & support | 2012 |
| Securitatem Ltd | Administrative & support | 2022 |
| Securitatem Operations Limited | Extraterritorial | 2019 |
| Securitatem Training Limited | Extraterritorial | 2019 |
| Security and Electronic Solutions Limited | Administrative & support | 2010 |
| Security Systems Maintenance Ltd | Administrative & support | 2009 |
| Securtech Limited | Construction | 2020 |
| SEE IT 24:7 Limited | Arts & recreation | 2001 |
| SEE Through Imaging Ltd | Professional & scientific | 2024 |
| Seeclear Reactive Limited | Construction | 2023 |
| Seeclear Services Group Limited | Administrative & support | 2016 |
| Seeker Design Ltd | Professional & scientific | 2025 |
| Seers Property Development Limited | Construction | 2011 |
| Seethetrail Ltd | Wholesale & retail | 2022 |
| Segel Ltd | Administrative & support | 2016 |
| Sekisui Diagnostics (UK) Limited | Manufacturing | 2010 |
| Seku Ltd | Transport & logistics | 2026 |
| Selale Ltd | Hospitality | 2026 |
| Select Learning (Maidstone) Limited | Education | 2001 |
| Select Learning Property Holdings Limited | Education | 2018 |
| Select Learning Property Limited | Education | 2018 |
| Select Star Limited | Information & communication | 2019 |
| Selectrix (Kent) Limited | Construction | 2010 |
| Sellenox Ltd | Wholesale & retail | 2026 |
| Sellertoolkit Limited | Information & communication | 2023 |
| Sellindge Practice Limited | Health & social care | 2008 |
| Selma Logistics Ltd | Transport & logistics | 2025 |
| Seltrad Ltd | Professional & scientific | 2012 |
| Semidemi Consulting Ltd | Professional & scientific | 2025 |
| SEMMA4 Limited | Wholesale & retail | 2025 |
| Sen-Powered Academy Limited | Education | 2024 |
| Sena Holdings Limited | Professional & scientific | 2016 |
| Senacre Ltd | Construction | 2023 |
| Senacre Tandoori Maidstone Limited | Hospitality | 2026 |
| Senbarlas Limited | Hospitality | 2024 |
| Send Success UK Ltd | Education | 2021 |
| Senergy Projects Limited | Manufacturing | 2021 |
| Senior Social Ltd | Information & communication | 2026 |
| Sensitive Care Ltd | Health & social care | 2022 |
| Sensory Audiology & Optical Recruitment Ltd | Administrative & support | 2023 |
| Sentena Ltd | Hospitality | 2015 |
| Sentinel Construction Services Limited | Construction | 1988 |
| Separex Ltd | Professional & scientific | 2019 |
| Seratuana Ltd | Real estate | 2025 |
| Serendipity Taste Ltd | Hospitality | 2016 |
| Serene IV Ltd | Other services | 2024 |
| Serenity Flooring Ltd | Construction | 2014 |
| Serenity School Maidstone Ltd | Education | 2023 |
| Serotine Consulting Limited | Professional & scientific | 2018 |
| Serpro Limited | Wholesale & retail | 2009 |