| Service Partner Corporation Limited | Transport & logistics | 2009 |
| Service Synk Limited | Administrative & support | 2025 |
| SES Electrical Solutions Ltd | Construction | 2011 |
| SET Free Foundation Ltd | Health & social care | 2023 |
| SET Motors Limited | Transport & logistics | 2014 |
| Setanta Trade Ltd | Construction | 2026 |
| Seth & Mikael Ltd | Hospitality | 2023 |
| Seth Marine Consultants Ltd | Administrative & support | 2023 |
| SETSTR8 Ltd | Professional & scientific | 2007 |
| Sett Games Ltd | Arts & recreation | 2025 |
| Sevenoaks Investments Limited | Construction | 2011 |
| Sevenoaks Physiotherapy Limited | Health & social care | 2012 |
| Sevenoaks Roofing Contractors Ltd | Construction | 2024 |
| Sevenoaks Theatre Productions Limited | Arts & recreation | 2019 |
| Sewaro Ltd | Hospitality | 2025 |
| Seymour Smith Limited | Professional & scientific | 2010 |
| Seymours Orchard Limited | Real estate | 2014 |
| SFL Consultants Limited | Professional & scientific | 2023 |
| Sfuya Ltd | Wholesale & retail | 2021 |
| SG Global Finco Limited | Financial services | 2019 |
| SG Global Topco Limited | Professional & scientific | 2019 |
| SG Property Maintenance Ltd | Construction | 2017 |
| SG Team Limited | Other services | 2020 |
| SG7 Construction Ltd | Manufacturing | 2021 |
| SGA Kent Construction Ltd | Construction | 2026 |
| SGJ Associates Limited | Other services | 2009 |
| SGM Heating Ltd | Construction | 2017 |
| SGN Venture Ltd | Real estate | 2025 |
| SH Bureau Limited | Professional & scientific | 2012 |
| Sh.Ltd.Trade Ltd | Construction | 2024 |
| Shady Deals Limited | Extraterritorial | 1994 |
| Shaheeneb Holdings Limited | Financial services | 2026 |
| Shaheeneb Ltd | Wholesale & retail | 2026 |
| Shakespeare Property Gillingham Ltd | Construction | 2020 |
| Shakespeare's Cake Limited | Information & communication | 2003 |
| Shalom Smiles Limited | Health & social care | 2016 |
| Shane & Bridge Limited | Professional & scientific | 2014 |
| Shape Your Spaces Limited | Extraterritorial | 2022 |
| Sharbel Media Ltd | Professional & scientific | 2025 |
| Shared Family Circ Limited | Education | 2025 |
| Shark Oceanic Limited | Information & communication | 2020 |
| Sharp and Hill I.T. Services Limited | Information & communication | 2002 |
| Sharp Intake Classics (Kent) Ltd | Wholesale & retail | 2020 |
| Shaw Patio Services Ltd | Construction | 2020 |
| Shawbrook Properties Limited | Households | 1990 |
| Shaz Meds Solutions Limited | Health & social care | 2026 |
| SHE Management (UK) Limited | Professional & scientific | 2002 |
| SHE Management Limited | Professional & scientific | 2008 |
| SHE Paints Ltd | Construction | 2023 |
| Shea Building Services Limited | Construction | 2019 |
| Shearwater Ventures Limited | Information & communication | 2012 |
| Shegon Enterprise Ltd | Transport & logistics | 2024 |
| Shen Dragon Limited | Financial services | 2007 |
| Shepherd & Sons Contracting Ltd | Construction | 2023 |
| Shepherd Estates Ltd | Real estate | 2023 |
| Shepherds Property Limited | Real estate | 2024 |
| Shephill Trading Ltd | Wholesale & retail | 2018 |
| Sheppey Court Management Company Ltd | Real estate | 2022 |
| Sheppey United Football Club Limited | Arts & recreation | 2013 |
| Sherbet Limited | Information & communication | 1996 |
| Sherwell Newark Limited | Financial services | 2000 |
| Shesays Limited | Other services | 2011 |
| Shield Property Management Limited | Construction | 2022 |
| Shiels Construction Services Limited | Construction | 2009 |
| Shile Ltd | Administrative & support | 2018 |
| Shilling International Limited | Financial services | 2025 |
| Shillingford Solutions Limited | Information & communication | 2017 |
| Shine Today Limited | Education | 2017 |
| Shiris Property Management Ltd | Real estate | 2023 |
| Shirley Court Management Company Limited | Households | 1993 |
| Shirley Court SW16 RTM Company Limited | Households | 2024 |
| Shnlaw Limited | Administrative & support | 2024 |
| Shock FX Limited | Arts & recreation | 2012 |
| Shopeaze Ltd | Wholesale & retail | 2025 |
| Shopnest Emporium Ltd | Wholesale & retail | 2023 |
| Short Handle Studios Ltd | Professional & scientific | 2026 |
| Shovin Ltd | Wholesale & retail | 2020 |
| Shoztech Ltd | Wholesale & retail | 2020 |
| Shpd Accountants Ltd | Professional & scientific | 2000 |
| Shpd Group Limited | Professional & scientific | 2009 |
| Shree Rang Avdhoot Limited | Wholesale & retail | 2022 |
| Shristi and Shrish Neupane Limited | Real estate | 2025 |
| Shum Investments Limited | Real estate | 2025 |
| Shurwen Brand Ltd | Wholesale & retail | 2025 |
| Sian Trading Limited | Wholesale & retail | 2021 |
| Sibley Pares (MKH Clokes) Limited | Real estate | 2013 |
| Sibley Pares (Taylor Riley) Limited | Real estate | 2016 |
| Sibley Pares LLP | | 2015 |
| Siciliano Pizzeria Ltd | Hospitality | 2022 |
| Sidor M Ltd | Transport & logistics | 2018 |
| Sidtek Solutions Limited | Real estate | 2021 |
| Sierra Hotel Ltd | Households | 2020 |
| SIF Events Ltd | Information & communication | 2024 |
| SIG Transport Ltd | Manufacturing | 2019 |
| Sighpea Limited | Information & communication | 2014 |
| Sigma Electrical & Controls Ltd | Manufacturing | 2026 |
| Sigma Managed Services Ltd | Wholesale & retail | 2020 |
| Sign Graphics Ltd | Professional & scientific | 2025 |
| Sign Update Limited | Information & communication | 2002 |
| Signature Image Consultants Limited | Professional & scientific | 1996 |