| Sales Velocity Ltd | Extraterritorial | 2017 |
| Sally Laughton Limited | Professional & scientific | 2015 |
| Sally's-Shutters Ltd | Wholesale & retail | 2020 |
| Salon 1606 Limited | Professional & scientific | 2022 |
| Salon 211 Limited | Other services | 2025 |
| Salt Society Creative Ltd | Manufacturing | 2024 |
| Saltersley Hall Developments Ltd | Administrative & support | 2023 |
| Salthedgehog Limited | Real estate | 2024 |
| Salubra Capital Ltd | Financial services | 2024 |
| SAM Williamson Solutions Ltd. | Information & communication | 2012 |
| Sama Atelier Ltd | Wholesale & retail | 2026 |
| Samaco International Paper Agents Limited | Wholesale & retail | 2024 |
| Samaita Ltd | Manufacturing | 2024 |
| Samfik Foods Limited | Hospitality | 2025 |
| Sampson Developments North West Limited | Real estate | 2018 |
| Sampson Lettings Limited | Real estate | 2015 |
| Samuel Paul Limited | Manufacturing | 2025 |
| Sanbal LLP | | 2025 |
| Sancay Limited | Hospitality | 2024 |
| Sanctabase Ltd | Information & communication | 2026 |
| Sandhills Estates Limited | Real estate | 2011 |
| Sandpiper Quay Limited | Real estate | 2020 |
| Sandringham RTM Company Ltd | Households | 2017 |
| Sands Lettings Limited | Real estate | 2003 |
| Sandten Limited | Health & social care | 2022 |
| Sandwich Heaven Broken Cross Ltd | Hospitality | 2020 |
| Sapphire Hotel Collection Ltd | Hospitality | 2018 |
| Sarah Humphreys Associates Ltd | Professional & scientific | 2020 |
| Sarah Teagle Ltd | Administrative & support | 2023 |
| Sasen Global Limited | Professional & scientific | 2026 |
| Satmap Systems Limited | Manufacturing | 2005 |
| Satori Homes (NW) Limited | Real estate | 2018 |
| Satskr Limited | Real estate | 2024 |
| Saurer Fibrevision Limited | Manufacturing | 1998 |
| Saville Street Garage Limited | Wholesale & retail | 1963 |
| Saving the Survivors Ltd. | Health & social care | 2014 |
| SB Educational Services Limited | Education | 2004 |
| Sbav Consultant Limited | Professional & scientific | 2018 |
| SBC 2018 Limited | Real estate | 2018 |
| SC Design Services Ltd. | Administrative & support | 2007 |
| SC360 Ltd | Arts & recreation | 2014 |
| Scale and Corrosion Apparatus Ltd | Manufacturing | 2017 |
| Scantech International Limited | Professional & scientific | 2002 |
| Scarfell Limited | Wholesale & retail | 2010 |
| Scaz Consulting Ltd | Professional & scientific | 2025 |
| Schafer Systems (UK) Limited | Administrative & support | 2004 |
| School Chair Shop Limited | Wholesale & retail | 2019 |
| School Improvers UK Limited | Professional & scientific | 2014 |
| Schoolgenie Community Interest Company | Education | 2020 |
| Schoolsrus Limited | Wholesale & retail | 2014 |
| Schuss Consulting Ltd | Professional & scientific | 2015 |
| Schvitz Limited | Information & communication | 2019 |
| Science for Social Good CIC | Professional & scientific | 2022 |
| Scito Ltd | Professional & scientific | 2020 |
| SCL Nominees Limited | Extraterritorial | 2017 |
| Scoble Holdings Limited | Real estate | 2023 |
| Scores Drawn Ltd | Wholesale & retail | 2017 |
| Scotch EGG Films Ltd | Information & communication | 2021 |
| Scott Hardy Ltd | Wholesale & retail | 2020 |
| Scrapwise Limited | Water & waste | 2022 |
| Screed Warehouse Ltd | Wholesale & retail | 2022 |
| Sculpt & Shred Ltd | Arts & recreation | 2024 |
| SD Jackson Building Ltd | Construction | 2008 |
| SDC Client Services Ltd | Professional & scientific | 2025 |
| SDK Logistics Limited | Transport & logistics | 2023 |
| SDR Circular IT Ltd | Information & communication | 2025 |
| Seaa Holdings Limited | Financial services | 2023 |
| Seamless Surface Design Ltd | Construction | 2026 |
| Sean Mccay Consulting Limited | Professional & scientific | 2024 |
| SEB Assets Limited | Real estate | 2008 |
| SEB Wines Limited | Wholesale & retail | 2022 |
| SEB World Limited | Professional & scientific | 2022 |
| Seba Property Group Ltd | Real estate | 2026 |
| Sebliving Limited | Real estate | 2022 |
| Sebspace Limited | Real estate | 2019 |
| Secondo Leisure Ltd | Arts & recreation | 2018 |
| Secure Data Recycling (South) Ltd | Water & waste | 2024 |
| Secure Data Recycling Ltd | Water & waste | 2014 |
| Secure PC Renew Ltd | Other services | 2019 |
| Sedulos Group Ltd | Administrative & support | 2021 |
| Seed Arboriculture Ltd | Professional & scientific | 2019 |
| Select Car Sales 1 Ltd | Wholesale & retail | 2025 |
| Selene Medical Communications Ltd | Professional & scientific | 2020 |
| Self Reliance Services Ltd | Administrative & support | 2025 |
| Sellfish Tackle Limited | Other services | 2009 |
| Sellyoak Limited | Real estate | 2018 |
| Sementum Ltd | Professional & scientific | 2024 |
| Semper Prorsum Properties Ltd | Real estate | 2025 |
| SEN Therapy AP Ltd | Education | 2026 |
| Sen-Therapy Limited | Education | 2025 |
| Sencourage Limited | Arts & recreation | 2022 |
| Sending Love Gifts Limited | Wholesale & retail | 2011 |
| Sensory Wise Owls Ltd | Health & social care | 2023 |
| Sentinel Power Systems Limited | | 1973 |
| Seques Limited | Extraterritorial | 2018 |
| Serafin Real Estate Ltd | Real estate | 2019 |
| Serendipity Developments International Ltd | Manufacturing | 2023 |
| Serendipity Property Developments Limited | Construction | 2004 |
| Serendipity Property Management Ltd | Households | 2024 |
| Seriously Frank Ltd | Arts & recreation | 2020 |