| Servimed Limited | Manufacturing | 2013 |
| Settled Design Limited | Professional & scientific | 2025 |
| Settvale Ltd | Wholesale & retail | 2002 |
| Settvale Plumbing & Heating Merchants Limited | Wholesale & retail | 1985 |
| Seven Wonders Limited | Arts & recreation | 2012 |
| SEVEN52 Limited | Professional & scientific | 2019 |
| Seventer Ltd | Professional & scientific | 2018 |
| Sewsewhappy Ltd | Wholesale & retail | 2021 |
| Seymour Transport Limited | Transport & logistics | 2002 |
| Sfam Property Limited | Manufacturing | 2023 |
| SFC Advisory Ltd | Administrative & support | 2015 |
| SFC Algbra (Nominees) Ltd | Extraterritorial | 2020 |
| SFC BBI Nominees Ltd | Other services | 2019 |
| SFC Capital Partners Ltd | Financial services | 2014 |
| SFC Earth Ltd | Financial services | 2021 |
| SFC Fens Ltd | Administrative & support | 2017 |
| SFC Nominees Limited | Other services | 2017 |
| Sfmdc Ltd | Professional & scientific | 2025 |
| SG Builders Ltd | Construction | 2021 |
| SG Properties (Cheshire) Limited | Real estate | 2024 |
| SH Electrical Contractors Limited | Construction | 2023 |
| Shackleton Stott Limited | Professional & scientific | 2009 |
| Shade Arcade Ltd | Wholesale & retail | 2025 |
| Shadow Consultancy Services Limited | Administrative & support | 2024 |
| Shadow Security Limited | Administrative & support | 2003 |
| Shamrock Bars Macclesfield Ltd | Hospitality | 2023 |
| Shapevoid Limited | Information & communication | 2020 |
| Share Coaching & Development Ltd | Administrative & support | 2023 |
| Shark Group Ltd | Wholesale & retail | 2017 |
| Sharon Jackson Consulting Limited | Information & communication | 2020 |
| Sharpe Data Analysis and Statistical Science Ltd | Information & communication | 2021 |
| Shaun Atherton Ltd | Information & communication | 2011 |
| Shaw Property Improvements Ltd | Construction | 2024 |
| Shepherd Pipeline Services Limited | Construction | 2026 |
| Sherazam & Co Limited | Wholesale & retail | 2015 |
| Sherbourne Park (ST. Helens) Management Company Limited | Households | 2006 |
| Sherratt Bespoke Property Services Limited | Real estate | 2021 |
| Shine-Pure Clean Solutions Ltd | Administrative & support | 2024 |
| Shines Luxury Car Wash Limited | Administrative & support | 2017 |
| Shining TOR Ltd | Wholesale & retail | 2024 |
| Shinko Ltd | Administrative & support | 2023 |
| Shirley Investments Limited | Real estate | 2019 |
| Shobnall Street Management Company Limited | Households | 2010 |
| Shorecliffe Rise Management Limited | Households | 2008 |
| Shorecliffe Rise RTM Company Limited | Households | 2022 |
| Short Productions Limited | Information & communication | 2022 |
| Short Staffed Solutions Ltd | Administrative & support | 2014 |
| Show ME HOW Limited | Education | 2011 |
| Showtime Theatre Productions Limited | Arts & recreation | 2018 |
| Shred IT Right Ltd | Extraterritorial | 2011 |
| Shred-Right Limited | Extraterritorial | 2010 |
| Shrigley Dyers Limited | Manufacturing | 1936 |
| Shumba Automotive Ltd | Wholesale & retail | 2024 |
| Shutlingsloe Ltd | Households | 2018 |
| Sian Rowsell Coaching and Training Limited | Professional & scientific | 2014 |
| SID Bespoke Limited | Construction | 2020 |
| Sida Cider Limited | Manufacturing | 2021 |
| Siddington Smithy Limited | Wholesale & retail | 2003 |
| Sidex Ltd | Information & communication | 2024 |
| Siempre MAS Limited | Construction | 2010 |
| Siena Digital Ltd | Information & communication | 2023 |
| Siena Property Group Ltd | Real estate | 2022 |
| Siena Property Rental Limited | Real estate | 2016 |
| Siena Ventures Ltd | Information & communication | 2022 |
| Sierra Health & Safety Ltd | Professional & scientific | 2023 |
| Siesta Fabrics Limited | Manufacturing | 2013 |
| Siesta International Holidays Limited | Administrative & support | 1980 |
| Signati Limited | Construction | 2015 |
| Signature Career Management Ltd | Administrative & support | 2017 |
| Signature Homes Marton Limited | Construction | 2019 |
| Signature Interiors Cheshire Ltd | Hospitality | 2023 |
| Signature Kitchen and Bathroom Installation Ltd | Construction | 2025 |
| Signeasyapps Limited | Real estate | 2002 |
| Signum Engineering Limited | Professional & scientific | 2013 |
| SIH Holdings Limited | Financial services | 2015 |
| Sika Business & IT Consultancy Limited | Information & communication | 2017 |
| Silhouette Capital Limited | Real estate | 2004 |
| Silk Access and Maintenance Limited | Construction | 2025 |
| Silk Automotive Limited | Wholesale & retail | 2015 |
| Silk Dent Care Ltd | Health & social care | 2019 |
| Silk Dental Care Ltd | Health & social care | 2011 |
| Silk Green Garden Services Ltd | Other services | 2022 |
| Silk Gymnastics Ltd | Arts & recreation | 2022 |
| Silk Hearing Ltd | Wholesale & retail | 2018 |
| Silk Heritage Trust | Education | 1987 |
| Silk Holdings Ltd | Real estate | 2025 |
| Silk House Therapy and Wellbeing Co-Operative Ltd | Other services | 2024 |
| Silk Park (GEL) South LLP | | 2014 |
| Silk Pianos Ltd | Wholesale & retail | 2026 |
| Silk Roofing Ltd | Construction | 2025 |
| Silk Town Racing Ltd | Arts & recreation | 2025 |
| Silk Town Scaffolding Ltd | Construction | 2018 |
| Silk Windows and Doors Ltd | Construction | 2022 |
| Silken Tree Ltd | Real estate | 2014 |
| Silkfitnesstherapy Ltd | Arts & recreation | 2019 |
| Silkology Ltd | Information & communication | 2026 |
| Silktown Group Ltd | Construction | 2018 |
| Silktown Software Ltd. | Information & communication | 2015 |
| Silktown Sport Ltd | Agriculture & fishing | 2025 |
| Sillkom Ltd | Professional & scientific | 2019 |