| E-Logize Limited | Information & communication | 2007 |
| E. L. Warrington Ltd | Administrative & support | 2023 |
| E.D Commercial Vehicle Repairs Ltd | Wholesale & retail | 2020 |
| Earls Stone Limited | Mining & quarrying | 1996 |
| Earthworm Capital Nominees Limited | Extraterritorial | 2016 |
| Ease Enterprise Limited | Health & social care | 2025 |
| Easi - Raft Limited | Manufacturing | 2011 |
| East Asia Technology Investments Limited | Professional & scientific | 2021 |
| East Cheshire Hospice | Health & social care | 1984 |
| East Cheshire Housing Consortium Limited | Hospitality | 1990 |
| East EGG Limited | Real estate | 2020 |
| Easterby Estates Ltd | Extraterritorial | 2024 |
| Eastinghall Ltd | Professional & scientific | 2007 |
| Eastman&Jackson Ltd | Wholesale & retail | 2024 |
| Eastside Healthcare Services Ltd | Health & social care | 2025 |
| Easy One Property Deals Ltd | Arts & recreation | 2021 |
| Easy Roof Box Rentals Limited | Real estate | 2019 |
| Easylinks Developments Limited | Extraterritorial | 2017 |
| Easylinks Homes Limited | Construction | 2018 |
| Easylinks Property Limited | Construction | 2017 |
| Easylinks UK Limited | Professional & scientific | 2022 |
| Eaton Connections Limited | Professional & scientific | 2026 |
| Eaton Prestige Cars Limited | Wholesale & retail | 2014 |
| Ebanking Integration Limited | Agriculture & fishing | 2008 |
| EBH Consulting Limited | Professional & scientific | 2024 |
| Ecclesbourne House (Duffield) Limited | Households | 2015 |
| ECH Trading Limited | Wholesale & retail | 2006 |
| Echelon Estates Limited | Real estate | 2012 |
| Echelon Projects Ltd | Real estate | 2008 |
| Echelon Properties Limited | Real estate | 2012 |
| Eco Bolt Limited | Extraterritorial | 2023 |
| Eco Pack Machinery Limited | Wholesale & retail | 2020 |
| Eco Wizard Limited | Construction | 2022 |
| Ecomonitor 2010 Limited | Professional & scientific | 2010 |
| Ecomplete SPV Limited | Wholesale & retail | 2021 |
| Ecsm Holding Ltd | Real estate | 2026 |
| Ecton Construction Limited | Construction | 2026 |
| ECU and Module Testing Ltd | Professional & scientific | 2024 |
| ED4MED Ltd | Professional & scientific | 2013 |
| Edeh Ltd | Professional & scientific | 2017 |
| Eden Point Cafe Limited | Hospitality | 2020 |
| Edge Biotech Ltd | Professional & scientific | 2025 |
| Edge Consulting (UK) Limited | Extraterritorial | 2008 |
| Edge International Consultants Limited | Professional & scientific | 2011 |
| Edgemere Construction Limited | Construction | 2018 |
| Edgemere Property Maintenance Limited | Other services | 2024 |
| Edgewood Interiors Limited | Construction | 2009 |
| Edit North Ltd | Other services | 2025 |
| Education Financial Consultancy Limited | Professional & scientific | 2013 |
| Edupension Ltd | Education | 2014 |
| Edwards and Blake Limited | Hospitality | 1997 |
| Edwards Construction & Stone Masonry Ltd | Construction | 2024 |
| Edwin Investments Limited | Professional & scientific | 2003 |
| EECO2 Energy Products Limited | Professional & scientific | 2024 |
| EECO2 Limited | Professional & scientific | 2023 |
| Eeuk Limited | Real estate | 2010 |
| Eezyice Ltd | Professional & scientific | 2020 |
| Efendi Barbers PVT Ltd | Other services | 2023 |
| Egerton Fine Foods Limited | Extraterritorial | 2012 |
| Egerton Transplant Limited | Wholesale & retail | 1963 |
| Egerton's Timber and Hardware Ltd | Wholesale & retail | 2021 |
| Egov Solutions Ltd | Information & communication | 2018 |
| Egtconsulting Limited | Professional & scientific | 2017 |
| EIGHT8 Lettings Limited | Real estate | 2012 |
| EJH Wealth LLP | | 2017 |
| EJL Consultancy Limited | Professional & scientific | 2024 |
| EJN Consulting Limited | Professional & scientific | 2023 |
| EKO Intelligence Ltd | Professional & scientific | 2024 |
| EL Badawy Ltd | Professional & scientific | 2021 |
| EL BEE Designs Limited | Wholesale & retail | 2005 |
| EL Piloto Ltd | Hospitality | 2024 |
| EL Piloto Manchester Ltd | Hospitality | 2025 |
| Elaf Lebanese Restaurant Ltd | Hospitality | 2022 |
| Elaf Restaurant Limited | Hospitality | 2019 |
| Elbbard Limited | Real estate | 1997 |
| Eldan (NO. 1) Limited | Professional & scientific | 1992 |
| Eldan (NO. 2) Limited | Professional & scientific | 1998 |
| Eldan (NO. 3) Limited | Professional & scientific | 1998 |
| Elderflower Solutions Limited | Professional & scientific | 2014 |
| Eleck Energy Ltd | Construction | 2023 |
| Electro Vapours UK Ltd | Wholesale & retail | 2014 |
| Electro Virium Ltd | Construction | 2016 |
| Electroserv (Temperature Controls & Sensors) Limited | Wholesale & retail | 1992 |
| Elegant Events Cheshire Limited | Hospitality | 2025 |
| Elephant Hand Car Wash Limited | Wholesale & retail | 2017 |
| Elevate Social Ventures Ltd | Financial services | 2025 |
| Elevation Property Media Ltd | Professional & scientific | 2026 |
| Elevation Scaffolding (North West) Ltd | Construction | 2024 |
| Eleven TEN Design Ltd | Professional & scientific | 2013 |
| Elhaho Limited | Administrative & support | 2020 |
| Elior UK Property Limited | Real estate | 2025 |
| Elissa Dobson Limited | Professional & scientific | 2020 |
| Elite Money Limited | Financial services | 2024 |
| Elite Refrigeration and Air Conditioning Limited | Construction | 2017 |
| Elite Shotcrete Limited | Construction | 2022 |
| Eljae Limited | Real estate | 1998 |
| Elkanah Enterprises Ltd | Other services | 2022 |
| ELL Egar Limited | Professional & scientific | 2023 |
| Ella and I Ltd | Wholesale & retail | 2021 |
| Elliot Chang Coaching Ltd | Education | 2015 |