| DIRECTORCO1 Limited | Professional & scientific | 2014 |
| Dirk Van Heck Limited | Professional & scientific | 2021 |
| Disability Information Bureau | Health & social care | 2007 |
| Discern Sustainability Limited | Professional & scientific | 2017 |
| Disco Developers Ltd | Real estate | 2024 |
| Discover Talent Solutions Limited | Administrative & support | 2022 |
| Discreet Drainage Solutions Ltd | Administrative & support | 2019 |
| Disseisin Limited | Professional & scientific | 2012 |
| Distribution Products Ltd | Professional & scientific | 2008 |
| Diverse Consulting Limited | Information & communication | 2009 |
| Diversitree Ltd | Professional & scientific | 2024 |
| Dixy Chicken Macclesfield Ltd | Hospitality | 2019 |
| Dizzy Media Ltd | Information & communication | 2020 |
| Djamco Digital Limited | Information & communication | 2021 |
| Djamco Holdings Limited | Financial services | 2021 |
| DJJ Automotive Limited | Wholesale & retail | 2016 |
| DK Investment Properties Ltd | Real estate | 2021 |
| DK Wood Ltd | Wholesale & retail | 2006 |
| Dkcp Ltd | Financial services | 2022 |
| DKM Business Solutions Limited | Professional & scientific | 2012 |
| DKM Property Solutions Ltd | Real estate | 2022 |
| DLK Art Design Construction Ltd | Construction | 2020 |
| DM Electrical Installations (NW) Ltd | Energy | 2025 |
| DM Sprint Ltd | Information & communication | 2026 |
| Dmam Holdings Ltd | Real estate | 2021 |
| DMT Vehicle Leasing UK Limited | Administrative & support | 2017 |
| DNA Athletic Limited | Manufacturing | 2018 |
| DNB Creative Limited | Administrative & support | 2010 |
| Dobells Limited | Agriculture & fishing | 2020 |
| Doberman Holdings Limited | Financial services | 2025 |
| Dockyard (Riverside) Limited | Hospitality | 2014 |
| Dockyard Barons Quay Limited | Hospitality | 2023 |
| Dockyard Brewery Limited | Manufacturing | 2015 |
| Dockyard First Street Limited | Hospitality | 2015 |
| Dockyard Leeds Limited | Hospitality | 2015 |
| Dockyard Media City Limited | Hospitality | 2013 |
| Dodd Property Group Ltd | Real estate | 2025 |
| Dog School Live Ltd | Education | 2020 |
| Dogsmart Grooming Limited | Administrative & support | 2024 |
| Dogsmart Mobile Grooming Ltd | Other services | 2024 |
| Doherty Anaesthetics Ltd | Health & social care | 2019 |
| Dolamite Mountain Properties Ltd | Manufacturing | 2026 |
| Dolly Daydream Cakery Ltd | Wholesale & retail | 2022 |
| DOM Webb Horses LLP | | 2011 |
| Domain Transport Limited | Transport & logistics | 2016 |
| DON Millers Wholesale Limited | Hospitality | 2011 |
| Donald Marshall Ltd | Extraterritorial | 2013 |
| Done Seven Limited | Professional & scientific | 2026 |
| Donnelly Foote Design Studio Ltd | Professional & scientific | 2022 |
| Doorco Limited | Manufacturing | 2007 |
| Dorchester Apartments MCR Ltd | Real estate | 2022 |
| Dorukhan Ltd | Arts & recreation | 2019 |
| DOT Crew Digital Ltd | Information & communication | 2022 |
| DOT Medical Limited | Wholesale & retail | 1997 |
| DOT Medical Products Ltd | Manufacturing | 2004 |
| Double Good Design & Art Direction Ltd | Professional & scientific | 2024 |
| Dove Hospitality Limited | Hospitality | 2022 |
| Dove Tree Montessori Nursery Limited | Education | 2023 |
| Doves Music Limited | Arts & recreation | 2003 |
| Dovetail Theatre Ltd | Arts & recreation | 2024 |
| Down to Earth Macclesfield Limited | Administrative & support | 2025 |
| Downes Heathcote Homes Limited | Real estate | 2016 |
| Downs Holdings Limited | Hospitality | 1977 |
| DP Electrical & Compliance Ltd | Construction | 2020 |
| DPH Consulting Ltd | Information & communication | 2021 |
| DPL Commissioning Services Ltd | Professional & scientific | 2021 |
| Dpsaat Ltd | Health & social care | 2024 |
| DR GER Graus OBE Consulting Ltd | Education | 2017 |
| DR Nick Fraser Limited | Health & social care | 2019 |
| DR William Hawthorne Limited | Health & social care | 2013 |
| DR21 Ltd | Wholesale & retail | 2015 |
| Dragonfly Estates Ltd | Construction | 2014 |
| Drain Nation Limited | Extraterritorial | 2012 |
| Drayson Properties Limited | Construction | 2024 |
| DRH Media Ltd | Information & communication | 2013 |
| Driftwood Events Ltd | Administrative & support | 2018 |
| Drone UP Ltd | Professional & scientific | 2018 |
| Drummers Keep Management Company Limited | Households | 2005 |
| DS Clinical Consultancy Limited | Professional & scientific | 2018 |
| DSM Apparel Limited | Wholesale & retail | 2025 |
| DTD Ventures Ltd | Wholesale & retail | 2025 |
| Dubai Fest Ltd | Arts & recreation | 2024 |
| Dublin Packet Chester Ltd | Hospitality | 2024 |
| Dukes Leisure Ltd | Other services | 2020 |
| Dukes Retail Direct Ltd | Wholesale & retail | 2025 |
| Dunas Investments Limited | Real estate | 2018 |
| DUO Estates Limited | Construction | 2005 |
| Durose Associates Ltd | Wholesale & retail | 2014 |
| DVH Bars Ltd | Hospitality | 2025 |
| DVS Trans Ltd | Transport & logistics | 2024 |
| DXU Limited | Professional & scientific | 2022 |
| DXY Macclesfield Ltd | Hospitality | 2023 |
| Dyad Projects Ltd | Administrative & support | 2023 |
| Dynamic and Digital Ltd | Other services | 2021 |
| Dynamic Business Media Limited | Professional & scientific | 2016 |
| Dynamic Technologies Limited | Information & communication | 2000 |
| E & G Properties Ltd | Real estate | 2017 |
| E & M Design and Building Ltd | Construction | 2022 |
| E & V Consult Limited | Financial services | 2024 |
| E Johnson Construction Limited | Construction | 2009 |