| Sankey Property Maintenance Limited | Construction | 2013 |
| Santi Studio Ltd | Other services | 2021 |
| Santorini Financial Planning Limited | Financial services | 2010 |
| Saph GG Limited | Professional & scientific | 2023 |
| Sapphire Estates (Leicester) Limited | Real estate | 2025 |
| Sarah Elizabeth Ltd | Other services | 2019 |
| Sarah Mercer Limited | Professional & scientific | 2011 |
| Saree Mandir Limited | Professional & scientific | 2002 |
| Saroko Energy Systems Ltd | Administrative & support | 2003 |
| Saroko Technologies Limited | Administrative & support | 2003 |
| SAS Drywall Solutions Limited | Construction | 2019 |
| Satisfy Loughborough Limited | Hospitality | 2024 |
| Satisfy Ming Limited | Hospitality | 2026 |
| Saunders Investment Group Limited | Financial services | 2025 |
| SAV Apartments UK Ltd | Real estate | 2025 |
| Savaloyz Limited | Hospitality | 2020 |
| Savitar Holdings Limited | Wholesale & retail | 2018 |
| Savoye Limited | Manufacturing | 1990 |
| Saxon Meadow Limited | Real estate | 2012 |
| SAY Coffee Ltd | Hospitality | 2019 |
| SB Young Property Ltd | Real estate | 2023 |
| SBP Investment Holdings Ltd | Real estate | 2023 |
| SC 2020 Ltd | Hospitality | 2020 |
| SC Franchise Consultancy Ltd | Professional & scientific | 2025 |
| SC Physiotherapy Ltd | Other services | 2025 |
| Scale Digital Ventures Ltd | Financial services | 2021 |
| Scale UP CS Ltd | Administrative & support | 2023 |
| Scales Estates Ltd | Real estate | 2023 |
| Scales Holdings Ltd | Financial services | 2026 |
| Scaleways (Leicester) Limited | Manufacturing | 1984 |
| Schappit Ltd | Information & communication | 2014 |
| Schawk Singapore PTE Ltd | | 2004 |
| Schews Ltd | Manufacturing | 2019 |
| Schofield Homes (Midlands) Limited | Construction | 2006 |
| Scholars Court (Coventry) Management Company Limited | Households | 2021 |
| School of National Equitation Limited | Agriculture & fishing | 1974 |
| School's OUT Rothley Ltd | Education | 2019 |
| Schwempf Limited | Information & communication | 2010 |
| Scientia Research Ltd | Professional & scientific | 2010 |
| Scientific Method Consulting Ltd | Professional & scientific | 2015 |
| Scml Consulting Limited | Professional & scientific | 2013 |
| Scoobyworld Limited | Wholesale & retail | 2003 |
| Scope Construction Ltd | Construction | 2011 |
| Scope Group Ltd | Real estate | 2017 |
| Scorpio Motorsport Limited | Arts & recreation | 2026 |
| Scott Baynes Limited | Manufacturing | 2013 |
| Scott Property Consultants Limited | Agriculture & fishing | 2008 |
| SCP Analysis Ltd | Administrative & support | 2023 |
| Scratch 4 Good Causes Limited | Arts & recreation | 2013 |
| Scratch'D & Scuff'D Ltd | Wholesale & retail | 2015 |
| Scrooge Mcduck Limited | Construction | 2014 |
| SCT Transport Ltd | Transport & logistics | 2014 |
| Scuderia Fantasma Ltd | Information & communication | 2026 |
| Sculpted Culture Clothing Limited | Extraterritorial | 2016 |
| SD Assets Ltd | Real estate | 2023 |
| SDH Products Ltd | Wholesale & retail | 2018 |
| SDK Consulting Engineers Limited | Construction | 2016 |
| SE Foods UK Ltd | Hospitality | 2026 |
| SE Technology Limited | Professional & scientific | 2017 |
| Seabed Ltd | Real estate | 2023 |
| Seaborium Ltd | Real estate | 2019 |
| Sealark Property Limited | Real estate | 2021 |
| Sean M Harrison Limited | Extraterritorial | 2015 |
| Search Impex Limited | Administrative & support | 1993 |
| Seatons Driving School Limited | Education | 2003 |
| SEB Electrical (Leicester) Ltd | Construction | 2016 |
| Secint Aerospace Ltd | Manufacturing | 2014 |
| Secint Air Support Limited | Manufacturing | 2019 |
| Secondseason Ltd | Wholesale & retail | 2026 |
| Secretclaim Limited | Real estate | 1996 |
| Secure-A-Field Holdings Ltd | Financial services | 2025 |
| Secure-A-Field Ltd | Construction | 2025 |
| Segura Systems Limited | Information & communication | 2012 |
| Selbys (Properties) Limited | Real estate | 1991 |
| Selenam Limited | Transport & logistics | 2017 |
| Self and Serenity Ltd | Health & social care | 2025 |
| Semcom Consulting Ltd | Information & communication | 2020 |
| Senior Fitness Limited | Arts & recreation | 2025 |
| Senizon Group Limited | Financial services | 2026 |
| Senkar Ltd | Real estate | 2026 |
| Sentinel Pro Ltd | Manufacturing | 2025 |
| Sepps Eats Ltd | Hospitality | 2022 |
| Sequoia Investments (UK) Ltd | Administrative & support | 2014 |
| Serenity Education Limited | Education | 2019 |
| Serenity Mind & Body Ltd | Health & social care | 2024 |
| Serenno Professional Services Limited | Professional & scientific | 2020 |
| Sergo Limited | Professional & scientific | 2023 |
| Serious Strength Academy Limited | Health & social care | 2021 |
| Serious Strength Gym Limited | Arts & recreation | 2018 |
| Servelec Abacus Limited | Professional & scientific | 2013 |
| Servelec Aura Limited | Professional & scientific | 2012 |
| Servelec Bidco Limited | Professional & scientific | 2017 |
| Servelec Education Limited | Professional & scientific | 2016 |
| Servelec Group Holdings Limited | Professional & scientific | 2017 |
| Servelec Healthcare Limited | Professional & scientific | 1977 |
| Servelec Limited | Professional & scientific | 1995 |
| Servelec Midco Limited | Professional & scientific | 2017 |
| Servelec Social Care Limited | Professional & scientific | 1999 |
| Servelec Topco Limited | Professional & scientific | 2017 |
| Servelec Youth Services Limited | Professional & scientific | 1973 |