| Rushcliffe Specialist Schools (Mickleover) Limited | Education | 2009 |
| Rushcliffe Specialist Schools Limited | Financial services | 2009 |
| Rushcliffe Uttoxeter SSP Limited | Real estate | 2026 |
| Rushcliffe Warwick SSP Limited | Real estate | 2024 |
| Rushes Management Limited | Households | 2003 |
| Russell Levenston Limited | Arts & recreation | 2024 |
| Russo & Lakha Limited | Financial services | 2020 |
| Rustic Kitchen and Deli Limited | Wholesale & retail | 2021 |
| Rustic Kitchen and Deli Loughborough Ltd | Hospitality | 2025 |
| Rustic Kitchen Media Ltd | Information & communication | 2025 |
| Ruthergan's Limited | Hospitality | 2025 |
| Rutland Railway Museum | Arts & recreation | 2005 |
| Ruudvisory Ltd | Professional & scientific | 2025 |
| Rvhfs Limited | Financial services | 2018 |
| RW Biosciences Ltd | Professional & scientific | 2016 |
| Rwbio Property Ltd | Households | 2023 |
| Rxpath Ltd | Professional & scientific | 2025 |
| Ryan Andrew Ltd | Real estate | 2020 |
| Ryan Hill Lettings Limited | Real estate | 2026 |
| Ryan Hill Limited | Real estate | 2016 |
| Ryan's Indian Cuisine Ltd | Hospitality | 2017 |
| Ryder Properties Limited | Real estate | 2006 |
| Rygar Solutions Ltd | Manufacturing | 2020 |
| Ryla Media Limited | Administrative & support | 2022 |
| Ryley Wealth Management Ltd | Financial services | 2005 |
| S & B Electrical Contractors Ltd | Construction | 2015 |
| S & M Coffee Limited | Hospitality | 2010 |
| S & O Construction Ltd | Construction | 2024 |
| S Aktar Limited | Professional & scientific | 2018 |
| S C H Bursell Limited | Financial services | 2013 |
| S Clayton Building Limited | Construction | 2019 |
| S Elliott Holdings Ltd | Real estate | 2026 |
| S H Car Hire Ltd | Administrative & support | 2026 |
| S Hogg Electrical Limited | Construction | 2024 |
| S J Enviro Services Ltd | Construction | 2009 |
| S J Roberts Limited | Professional & scientific | 2008 |
| S Lynch Plant Limited | Administrative & support | 2019 |
| S P P Maintenance Ltd | Other services | 2018 |
| S P Smith Sports Bar Ltd | Hospitality | 2026 |
| S Plumbing & Heating Ltd | Construction | 2021 |
| S R Scoggins Ltd | Professional & scientific | 2012 |
| S W Miles & Company Limited | Professional & scientific | 2023 |
| S Webster & Sons Limited | Real estate | 2018 |
| S&A PUB Co Ltd | Hospitality | 2024 |
| S&J Glentribe Leisure Limited | Agriculture & fishing | 2022 |
| S&S IT Consulting Ltd | Information & communication | 2021 |
| S.Doll Beauty Ltd | Administrative & support | 2023 |
| S.I.P.(Industrial Products)Limited | Manufacturing | 1968 |
| S.I.R Links Ltd | Real estate | 2020 |
| S.J. Event Consultancy Limited | Professional & scientific | 2004 |
| S.M.T.V Ltd | Transport & logistics | 2014 |
| S.P.I.T. Solutions [ENG] Ltd | Information & communication | 2016 |
| SA Cars (Derby) Ltd | Wholesale & retail | 2024 |
| SA Healthcare Clinic UK Limited | Other services | 2024 |
| SA Living Ltd | Real estate | 2023 |
| Saagar Midland Ltd | Hospitality | 2017 |
| Sabel Security Ltd | Information & communication | 2023 |
| Saca Cricket UK | Arts & recreation | 2022 |
| Sada Property Limited | Real estate | 2021 |
| Sadler Gate Ltd | Real estate | 2020 |
| Sadler Hairdressing Ltd | Other services | 2022 |
| Sae-Suecinematics Ltd | Professional & scientific | 2025 |
| SAF Holland UK Ltd | Transport & logistics | 1982 |
| Safaa Transport Ltd | Transport & logistics | 2018 |
| Safe Computing (Pensions) Limited | Information & communication | 1983 |
| Safe Computing Limited | Information & communication | 1975 |
| Safe Steel Installations Ltd | Manufacturing | 2009 |
| SAFEELECTRIC24/7 Ltd. | Construction | 2017 |
| Safekab Ltd | Transport & logistics | 2022 |
| Safeletting Time Ltd | Real estate | 2025 |
| Safety Surface Systems Limited | Professional & scientific | 2000 |
| Saffron & Silk Ltd | Hospitality | 2026 |
| Saha Property Developments Ltd | Real estate | 2024 |
| SAI IA Limited | Administrative & support | 2025 |
| SAI Pharma U.K. Limited | Professional & scientific | 2022 |
| Saif Linen Hire (Loughborough) Limited | Other services | 2014 |
| Saint Luke London Ltd | Wholesale & retail | 2013 |
| Saint-Gobain Construction Chemicals UK Limited | Manufacturing | 1958 |
| Sajeimpact Ltd | Arts & recreation | 2010 |
| Salaar Ltd | Hospitality | 2026 |
| Salamander C Ltd | Wholesale & retail | 2020 |
| Salem&Co Ltd | Manufacturing | 2025 |
| Sales Geek East Midlands Ltd | Professional & scientific | 2022 |
| Sally Chaffey Ltd | Health & social care | 2023 |
| SAM Smith Motor Group Ltd | Wholesale & retail | 2020 |
| SAM Smith Motor Retail Ltd | Wholesale & retail | 2015 |
| SAM Ward 13 Limited | Arts & recreation | 2015 |
| Samantha Downs Legal Services Limited | Professional & scientific | 2019 |
| Same Day Podiatry Ltd | Health & social care | 2022 |
| Sammie CAD Ltd | Information & communication | 2025 |
| Sammie Hanna School of Beauté Limited | Education | 2023 |
| Samochai Ltd | Wholesale & retail | 2022 |
| Samuel Wesson-Quibell Ltd | Wholesale & retail | 2023 |
| SAN Vera Ltd | Wholesale & retail | 2021 |
| Sanamente Services Limited | Health & social care | 2019 |
| Sanandtonio Ltd | Extraterritorial | 2014 |
| Sandicliffe Limited | Wholesale & retail | 1996 |
| Sandr Alliance Ltd | Professional & scientific | 2023 |
| Sane Creative Ltd | Professional & scientific | 2011 |
| Sanjeev Pattni Ltd | Health & social care | 2020 |