| Service Fest Ltd | Wholesale & retail | 2023 |
| SET for LET Ltd | Real estate | 2024 |
| SEVENTEEN7 Investments Limited | Real estate | 2023 |
| SEW Historical Limited | Manufacturing | 2010 |
| SF Motors Limited | Wholesale & retail | 2019 |
| SF Ventures Ltd | Hospitality | 2025 |
| SF Video & Photography Ltd | Information & communication | 2020 |
| SF Visual Media Ltd | Professional & scientific | 2023 |
| SFW Consulting East Midlands Ltd | Wholesale & retail | 2020 |
| SG50 UK Limited | Professional & scientific | 2016 |
| SGH Gobal Ltd | Administrative & support | 2025 |
| Sgme Limited | Real estate | 2024 |
| Shabnaz Sara Limited | Wholesale & retail | 2025 |
| Shaftesbury Clinic LLP | | 2008 |
| Shakehouse Loughborough Ltd | Manufacturing | 2021 |
| Shakti Foods Limited | Wholesale & retail | 2024 |
| Shamima Ltd | Professional & scientific | 2016 |
| Shan Healthcare Ltd | Health & social care | 2019 |
| Shana Company Sileby Ltd | Other services | 2023 |
| Shanes DE Ltd | Hospitality | 2024 |
| Sharp & Co. Lettings Ltd | Real estate | 2025 |
| Sharp Engineering Solutions Ltd | Professional & scientific | 2010 |
| Sharpe & Co. Accountants Limited | Professional & scientific | 2007 |
| Sharpe Property Solutions Ltd | Real estate | 2017 |
| Sharphill House Limited | Real estate | 2023 |
| Shepherds Bathrooms Limited | Wholesale & retail | 2010 |
| Shepshed Barbers Ltd | Other services | 2022 |
| Shepshed Learning Centre Ltd. | Education | 2022 |
| Shepshed MOT Centre Limited | Wholesale & retail | 2018 |
| Shepshed Nails Limited | Other services | 2022 |
| Shepshed News Limited | Wholesale & retail | 2022 |
| Shepshed Plumbing and Heating Ltd | Construction | 2019 |
| Shepshed Toy Library | Arts & recreation | 2013 |
| Sheqadvisory Ltd | Professional & scientific | 2023 |
| Sherry Creative Ltd | Information & communication | 2016 |
| Sherwood Commercial Vehicle Repair Centre Limited | Wholesale & retail | 1996 |
| Sherwood Recycling Limited | Professional & scientific | 1978 |
| Sherwood Self Store Limited | Extraterritorial | 2004 |
| Shifa Henna Limited | Wholesale & retail | 2021 |
| Shiltech Performance Cars Ltd | Wholesale & retail | 2002 |
| Shiltech Sales Limited | Wholesale & retail | 2017 |
| Shiny Property Ltd | Administrative & support | 2019 |
| Shiny Valeting Ltd | Other services | 2014 |
| Shire Mill Limited | Manufacturing | 2022 |
| Shires Investments (Leamington Spa) Limited | Hospitality | 2006 |
| Shires Investments Limited | Hospitality | 2001 |
| Shirt Koto Limited Limited | Manufacturing | 2026 |
| SHM Lettings Limited | Real estate | 2014 |
| Shogunmotors Ltd | Wholesale & retail | 2026 |
| Shorin-Ryu Seibukan UK Limited | Education | 2016 |
| Short & Long Capital Limited | Financial services | 2025 |
| Shorty's Barbers (Markfield) Ltd | Other services | 2017 |
| Showaddywaddy Merchandise Ltd | Wholesale & retail | 2022 |
| SHR UK Holdco Limited | Financial services | 2022 |
| Shreddies Ltd | Manufacturing | 2007 |
| Shree RAM Krishna Centre | Other services | 2004 |
| Shreeve and Mardell Limited | Wholesale & retail | 2013 |
| Shrydeh UK Ltd | Real estate | 2022 |
| Shutt Company Limited | Real estate | 2024 |
| Siam 25 Limited | Financial services | 2021 |
| Siba (UK) Limited | Wholesale & retail | 1994 |
| Sibs Properties Ltd | Real estate | 2024 |
| SIC Parvis Magna Ltd | Information & communication | 2019 |
| Sichuan Rivey Ltd | Hospitality | 2017 |
| Sidewinder Publishing Limited | Wholesale & retail | 2008 |
| Sielan Properties Ltd | Real estate | 2025 |
| SIG Systems Limited | Manufacturing | 2019 |
| Sigma United Ltd | Wholesale & retail | 2025 |
| Sign Shop (Loughborough) Limited | Administrative & support | 2006 |
| Signature Trading Limited | Professional & scientific | 2001 |
| Sileby Fabrications Limited | Manufacturing | 2003 |
| Sileby Holdco Limited | Professional & scientific | 2023 |
| Sileby Newco Limited | Professional & scientific | 2023 |
| Silebyspas Ltd | Construction | 2020 |
| Silicone Inks Limited | Manufacturing | 2001 |
| Silverton SPV Limited | Real estate | 2025 |
| Simad Holdings Ltd | Financial services | 2024 |
| Simiya Couriers Ltd | Transport & logistics | 2024 |
| Simon Shilton Lettings LLP | | 2012 |
| Simon Shilton Limited | Real estate | 2005 |
| Simon Williams Ltd | Manufacturing | 1997 |
| Simons and Sons Services Ltd | Construction | 2019 |
| Simple Films Limited | Information & communication | 1997 |
| Simple Will Ltd | Professional & scientific | 2017 |
| Simply Cuts Ltd | Other services | 2024 |
| Simply DA Best Lettings Ltd | Real estate | 2022 |
| Simply Gardens Barrowden Ltd | Administrative & support | 2019 |
| Simplygums Limited | Health & social care | 2014 |
| Simplylabs Limited | Construction | 2011 |
| Simpson Electrical Contractors Limited | Construction | 2023 |
| Sims Brand Design Ltd | Professional & scientific | 2014 |
| Simulanis UK Limited | Information & communication | 2020 |
| Sinfield Holdings Ltd | Financial services | 2021 |
| SIP & Thrive Ltd | Hospitality | 2025 |
| Sirani Publishing Limited | Information & communication | 2018 |
| Sirius Transformation Consultancy LLP | | 2021 |
| Sitwec Ltd | Professional & scientific | 2026 |
| Sivic Limited | Professional & scientific | 2023 |
| SIX 0 Eight Ltd | Education | 2024 |
| SIX Acre Nurseries Limited | Agriculture & fishing | 2017 |