| Safepoint Care Services Limited | Health & social care | 2021 |
| Safequal Construction Ltd | Construction | 2022 |
| Safequal Holdings Ltd | Financial services | 2024 |
| Safer Training Ltd | Professional & scientific | 2017 |
| Safespacetech CIC | Information & communication | 2024 |
| Safety Assistance Limited | Information & communication | 2023 |
| Safety Culture and Compliance Limited | Professional & scientific | 2020 |
| Safety PAL Limited | Professional & scientific | 2024 |
| Safety Point Ltd | Health & social care | 2025 |
| Safety Scaffolding Ltd | Construction | 2024 |
| Safety Supplies Ltd | Other services | 2020 |
| Safetymate Online Ltd | Information & communication | 2020 |
| Safewater Training Ltd | Education | 2024 |
| Saffa Builds Ltd | Construction | 2024 |
| Saffiyyah Paul Ltd | Wholesale & retail | 2023 |
| Saffron Oak Properties Ltd | Real estate | 2025 |
| Saffron Vanilla Co Ltd | Administrative & support | 2015 |
| Safi's Awaza Ltd | Hospitality | 2024 |
| Safi's JV 1 Limited | Financial services | 2021 |
| Safiamodesty Ltd | Wholesale & retail | 2024 |
| Safis Holding Company Limited | Financial services | 2021 |
| Safis L24 Ltd | Hospitality | 2021 |
| Safis L9 Ltd | Hospitality | 2021 |
| Safzee Ltd | Wholesale & retail | 2025 |
| Saga Care Ltd | Health & social care | 2019 |
| Sagaciti Limited | Construction | 2019 |
| Sage 1010 Ltd | Construction | 2017 |
| Sage Business Links Ltd | Professional & scientific | 2012 |
| Sage Business Services Ltd | Administrative & support | 2017 |
| Sage Business System Ltd | Wholesale & retail | 2021 |
| Sage Developments Ltd | Construction | 2025 |
| Sage Media National Limited | Professional & scientific | 2018 |
| Sage Orchid Limited | Hospitality | 2020 |
| Sage Property Lettings Ltd | Real estate | 2024 |
| Sagecorp Ltd. | Administrative & support | 2015 |
| Saghar Beauty Ltd | Other services | 2019 |
| Sagio Property Limited | Real estate | 2017 |
| Sagitta Holdings Limited | Professional & scientific | 2019 |
| Sagna Property Limited | Real estate | 2024 |
| Sahdev Property Ltd | Real estate | 2026 |
| Sahelz Ltd | Hospitality | 2026 |
| Sahil Repairs & Services Ltd | Other services | 2023 |
| Sahir House | Health & social care | 1999 |
| Sahodara Global Hospitality Ltd | Financial services | 2026 |
| Sahotra Trading Co Ltd | Wholesale & retail | 2026 |
| SAI Group Consultancy Ltd | Information & communication | 2022 |
| SAI Group Lettings Ltd | Real estate | 2025 |
| SAI Kedar Surgical Services Limited | Health & social care | 2016 |
| SAI Occupational Health Ltd | Health & social care | 2010 |
| SAI Property Estate Ltd | Real estate | 2024 |
| SAI Psych Limited | Health & social care | 2024 |
| Saiabdul Ltd | Real estate | 2025 |
| Saic Pro Ltd | Professional & scientific | 2025 |
| Saiguru Ltd | Wholesale & retail | 2017 |
| Saihari Ltd | Real estate | 2015 |
| Sail Academy Trust | Education | 2017 |
| Sail North Consulting Limited | Construction | 2012 |
| Sailing Intelligence Limited | Administrative & support | 2004 |
| Sailing Media Limited | Information & communication | 2004 |
| Sailor Tattoo Ltd | Other services | 2022 |
| Saint Jude Care Group Limited | Health & social care | 2023 |
| Saint Jude Residential Care Home Limited | Health & social care | 2014 |
| Saint Marks Property Co Limited | Real estate | 2016 |
| Saint Panther Ltd | Manufacturing | 2026 |
| Saints Boxing Promotions Ltd | Professional & scientific | 2025 |
| Saints Developments Ltd | Construction | 2025 |
| Saints Hairdressing Ltd. | Other services | 2010 |
| Saints Supermarket Ltd | Wholesale & retail | 2016 |
| Saio Explorations Ltd | Arts & recreation | 2025 |
| Sajalow Limited | Wholesale & retail | 2021 |
| Saka Grid Consultants Ltd | Professional & scientific | 2023 |
| Saka Ltd | Wholesale & retail | 2005 |
| Saka Porperty Ltd | Real estate | 2026 |
| Saker Limited | Financial services | 2023 |
| Sakr Services UK Limited | Real estate | 2010 |
| Sakthinivedha UK Limited | Wholesale & retail | 2024 |
| Sakura Spa Massage Limited | Health & social care | 2012 |
| Sakura Wellness Spa Limited | Health & social care | 2025 |
| SAL Properties NW Ltd | Real estate | 2024 |
| SAL Property Developments Ltd | Construction | 2025 |
| SAL Sabeel Ltd | Wholesale & retail | 2026 |
| Salaam Care Limited | Health & social care | 2021 |
| Salaam Care Services Ltd | Health & social care | 2019 |
| Salaam Street Limited | Wholesale & retail | 2025 |
| Salafa Selects Ltd | Wholesale & retail | 2024 |
| Salamander AV Solutions Ltd | Manufacturing | 2021 |
| Salamander Energy (Bualuang Holdings) Limited | Mining & quarrying | 2009 |
| Salamander Energy (S.E. Asia) Limited | Mining & quarrying | 2005 |
| Salami & Co (NW) Limited | Real estate | 2018 |
| Salar SON Limited | Wholesale & retail | 2024 |
| Salara Retail Ltd | Wholesale & retail | 2020 |
| Salasar Stores Ltd | Wholesale & retail | 2005 |
| Salbeck PD Ltd | Construction | 2017 |
| Salchi Ltd | Hospitality | 2016 |
| Salcomm Limited | Construction | 2019 |
| Salcos Homes NW Limited | Real estate | 2025 |
| Saleagreed Limited | Real estate | 2009 |
| Saledale Limited | Wholesale & retail | 2020 |
| Saleh Estates Ltd | Real estate | 2020 |
| Sales and Finance Ltd | Other services | 2022 |