| S.E Homes Ltd | Real estate | 2020 |
| S.E.E Enterprises Ltd | Administrative & support | 2024 |
| S.F. Smylie Consulting Limited | Professional & scientific | 2015 |
| S.G. & P. Payne Limited | Manufacturing | 2005 |
| S.G.C.C. Ltd | Real estate | 2025 |
| S.H.U.K Highways & Civils Ltd | Administrative & support | 2020 |
| S.H.U.K Housing & Surveying Ltd | Construction | 2025 |
| S.I.S Maintenance Ltd | Professional & scientific | 2022 |
| S.K Vuetaki Ltd | Construction | 2019 |
| S.L.A. Marketing Ltd | Construction | 2014 |
| S.L.G. Solutions Ltd | Arts & recreation | 2017 |
| S.M.K. Engineering (UK) Limited | Construction | 2013 |
| S.M.O.B. Consulting Limited | Professional & scientific | 2017 |
| S.M.P. Fruit Suppliers Limited | Wholesale & retail | 1991 |
| S.N Projects Limited | Real estate | 2024 |
| S.P.A.E. Limited | Households | 2018 |
| S.P.H. NW Ltd | Construction | 2024 |
| S.R.Legal & Financial Consultancy Limited | Other services | 2011 |
| S.R.Plastering & Rendering Ltd | Construction | 2017 |
| S.S.M.K. (Lakeside) Ltd | Hospitality | 2014 |
| S.T Electrical and Security Ltd | Construction | 2016 |
| S.T. Molloy Limited | Construction | 2011 |
| S.T. Retail Limited | Wholesale & retail | 2004 |
| S.W.Autos Ltd | Wholesale & retail | 2025 |
| S.W.Woods Maintenance Limited | Construction | 2025 |
| S.Z.E. Management Consulting Ltd | Professional & scientific | 2020 |
| S1406 Limited | Real estate | 2025 |
| S25 Property Ltd | Real estate | 2016 |
| S2S Health Limited | Other services | 2013 |
| S3K Developers PVT Ltd | Information & communication | 2017 |
| SA Bloom Ltd | Wholesale & retail | 2025 |
| SA Building NW Ltd | Construction | 2024 |
| SA Global Meat Ltd | Wholesale & retail | 2025 |
| SA NW Ltd | Hospitality | 2026 |
| SA Primex Ltd | Wholesale & retail | 2025 |
| Sa.Healthforyou Limited | Health & social care | 2025 |
| Saab Global UK Ltd | Wholesale & retail | 2026 |
| Saadprimetraders Ltd | Wholesale & retail | 2023 |
| Saansiya Ltd | Real estate | 2016 |
| Saanvi Glam Ltd | Other services | 2019 |
| Saas Property Management Ltd | Real estate | 2025 |
| SAB Aesthetics Limited | Wholesale & retail | 2019 |
| Sabah Transport(Liverpool) Ltd | Transport & logistics | 2021 |
| Sabai Thai & Sports Massage Ltd | Other services | 2023 |
| Sabaoth Care Ltd | Administrative & support | 2015 |
| Sabet Hypnotherapy Limited | Health & social care | 2024 |
| Sabford Limited | Administrative & support | 1977 |
| Sabi Source Ltd | Wholesale & retail | 2024 |
| Sabrina Construction Limited | Construction | 2016 |
| Sabryna Limited | Hospitality | 2025 |
| Sabz Sip&Scoop Ltd | Hospitality | 2026 |
| SAC Mobile Barber Services Ltd | Hospitality | 2021 |
| Saca Group Limited | Wholesale & retail | 2020 |
| Saccahra Skincare Ltd | Wholesale & retail | 2025 |
| Sachs Consulting Ltd | Professional & scientific | 2023 |
| Sacks Homes Limited | Real estate | 2017 |
| Sacral Medical Ltd | Health & social care | 2025 |
| Sacred Boredom Film Co. Ltd | Information & communication | 2025 |
| Sacred Swan Tattoo Ltd | Other services | 2025 |
| SAD Lads Ltd | Information & communication | 2025 |
| SAD SAM Limited | Professional & scientific | 2019 |
| Sada Capital Investments Ltd | Financial services | 2025 |
| Saddleworth Development NW Ltd | Real estate | 2024 |
| Sade Solutions Limited | Professional & scientific | 2025 |
| Sadeafricanpride Ltd | Hospitality | 2025 |
| Sadiku Estates Limited | Real estate | 2020 |
| SAE (UK) Holdings Limited | Financial services | 2022 |
| SAE 1 Ltd | Real estate | 2026 |
| SAE Education Limited | Extraterritorial | 2008 |
| Saeng JAN Spa Ltd | Other services | 2020 |
| Saezcap Consulting Limited | Professional & scientific | 2024 |
| SAF Communication Limited | Wholesale & retail | 2023 |
| Safa Property Limited | Real estate | 2015 |
| Safari Care and Support Services Ltd | Health & social care | 2023 |
| Safari Coffe Limited | Hospitality | 2025 |
| Safari Liverpool Ltd | Hospitality | 2023 |
| Safariland UK Holding Limited | Financial services | 2011 |
| Safariland UK Ltd. | Manufacturing | 2010 |
| Safe Business Links Ltd | Professional & scientific | 2020 |
| Safe Comms Ltd | Information & communication | 2020 |
| Safe FIX Heating Ltd | Construction | 2022 |
| Safe GAS Services Plumbing & Heating Limited | Construction | 2019 |
| Safe Hands Liverpool Limited | Health & social care | 2008 |
| Safe N Sound Systems Ltd | Administrative & support | 2013 |
| Safe Pathways Ltd | Health & social care | 2024 |
| Safe Space Psychotherapy CIC | Health & social care | 2025 |
| Safe Spaces Therapy Rooms Ltd | Real estate | 2026 |
| Safe Steps Ltd | Information & communication | 2018 |
| Safe Welkin Limited | Information & communication | 2023 |
| Safebuy Vault Ltd | Financial services | 2019 |
| Safeclimb Ltd | Wholesale & retail | 2006 |
| Safeguard Management Services Ltd | Administrative & support | 2021 |
| Safeguarding Standards Organisation Ltd | Professional & scientific | 2026 |
| Safehands Enterprises Ltd | Real estate | 2024 |
| Safehaven Complex Care Ltd | Health & social care | 2025 |
| Safehavennorthwest Ltd | Health & social care | 2025 |
| Safehorizon Care Group Ltd | Health & social care | 2025 |
| Safelec Building Services Limited | Construction | 2005 |
| Safelec Electrical (Liverpool) Ltd | Construction | 2007 |
| Safely Care Limited | Health & social care | 2025 |