| Sensitivita Ltd | Health & social care | 2022 |
| Sentry Collective Limited | Professional & scientific | 2021 |
| Sequential Systems Ltd | Information & communication | 2001 |
| Serada Limited | Administrative & support | 2025 |
| Seraph Technologies Limited | Manufacturing | 2020 |
| Serene Beauty Group Ltd | Health & social care | 2019 |
| Serenity & Glow Ltd | Other services | 2025 |
| Serenity at the Forge Limited | Other services | 2025 |
| Serenity Haven Spa & Treatment Rooms Limited | Other services | 2025 |
| Serenity Property Experts Ltd | Real estate | 2023 |
| Serha Ltd. | Health & social care | 2016 |
| Servatum Limited | Financial services | 2012 |
| Service Excellence Providers (SEP) Ltd | Construction | 2013 |
| Services (North Place) Limited | Administrative & support | 1972 |
| Serviset Properties Limited | Real estate | 1970 |
| Sesvanderhave UK Limited | Agriculture & fishing | 2012 |
| Seven Districts Limited | Manufacturing | 2019 |
| Seven River Equestrian Ltd | Agriculture & fishing | 2022 |
| Seventy Park Walk (London) Ltd | Extraterritorial | 1999 |
| SF Technology Solutions Ltd | Professional & scientific | 2014 |
| SFA Distribution Ltd | Wholesale & retail | 2025 |
| SFR Recruitment Solutions Ltd | Administrative & support | 2018 |
| SG Haulage (Holdings) Limited | Financial services | 2023 |
| SG Haulage Limited | Transport & logistics | 2005 |
| SG Properties (Lincoln) Limited | Real estate | 2018 |
| SG Unity Care Ltd | Administrative & support | 2026 |
| Sgbs (Lincoln) Ltd | Construction | 2014 |
| Sgdd Medical Ltd | Health & social care | 2022 |
| SGF Trans Ltd | Transport & logistics | 2013 |
| SGG Support Services Limited | Professional & scientific | 2018 |
| Sggs Properties Limited | Real estate | 2021 |
| SGH-6 Services Ltd | Wholesale & retail | 2019 |
| SGM Financial Management Ltd | Professional & scientific | 2021 |
| SGT Support Ltd | Administrative & support | 2025 |
| Sgtuk.Com Ltd | Professional & scientific | 2023 |
| SH Delivery Consulting Ltd | Professional & scientific | 2026 |
| SH Fencing & Gates Ltd | Construction | 2023 |
| SH Itsec Ltd | Information & communication | 2022 |
| Shack Aquatics Ltd | Wholesale & retail | 2024 |
| Shackleford Properties Ltd | Real estate | 2017 |
| Shackleton Aviation Group C.I.C. | Manufacturing | 2017 |
| Shakespeare Management Co Ltd | Households | 2017 |
| Shakespeare Mews Limited | Real estate | 2020 |
| Shakespeare PUB Company Limited | Hospitality | 2006 |
| Shakespeare Street Garage Limited | Wholesale & retail | 2006 |
| Shakey Foundations Properties Ltd | Real estate | 2022 |
| Shane Graves Bodyworks Limited | Wholesale & retail | 2005 |
| Shaping Healthy Minds Academy CIC | Education | 2023 |
| Shaping Spaces Ltd | Real estate | 2026 |
| Shark Blinds Limited | Other services | 2018 |
| Sharma Property and Investments Ltd | Real estate | 2024 |
| Sharpe Civil Engineering Ltd | Construction | 2021 |
| Sharpe Kitchens Ltd | Construction | 2023 |
| Sharpe Seeds Limited | Professional & scientific | 1920 |
| Sharpe Williams Design Limited | Professional & scientific | 2023 |
| Sharps Stow Limited | Manufacturing | 2006 |
| Sharr Co Ltd | Real estate | 2026 |
| Sharron Morris Medical Limited | Health & social care | 2015 |
| Shatoos Barber Ltd | Other services | 2024 |
| Shaw Consulting (East Midlands) Limited | Professional & scientific | 2019 |
| Shaw Family Holdings Limited | Financial services | 2015 |
| Shaw Hughes Solar Energy Ltd | Construction | 2025 |
| Shaw Property Management (Lincoln) Ltd | Real estate | 2018 |
| Shaw's Agricultural Contractors Ltd | Agriculture & fishing | 2024 |
| Shawwalgoods Ltd | Wholesale & retail | 2025 |
| Shayner Scaffolding Services Ltd | Construction | 2021 |
| Shea Architectural Holdings Ltd | Financial services | 2024 |
| Shears Landscaping (Lincs) Limited | Other services | 2001 |
| Sheep Leep Contractors Limited | Agriculture & fishing | 2016 |
| Sheep Leys Limited | Real estate | 2024 |
| Shefar Ltd | Wholesale & retail | 2022 |
| Sheffield Flower School Limited | Education | 2020 |
| Shelbourn Properties Holdings Limited | Real estate | 2023 |
| Shelford Oncology Ltd | Health & social care | 2026 |
| Shells Support Solutions Ltd | Administrative & support | 2024 |
| Sherbetov Ltd | Transport & logistics | 2018 |
| Sheroars Marketing Ltd | Professional & scientific | 2025 |
| Sherwood Creations Limited | Construction | 2025 |
| Shield Space Limited | Professional & scientific | 2025 |
| Shield UAS Solutions Ltd | Public administration | 2022 |
| Shieldwall Ltd | Agriculture & fishing | 2016 |
| Shift Key Cyber Ltd | Information & communication | 2021 |
| Shiftanddrift Limited | Transport & logistics | 2026 |
| Shine and Bright Limited | Administrative & support | 2023 |
| Shine Time Lincoln Ltd | Administrative & support | 2021 |
| Shire Grab Hire Ltd | Administrative & support | 2023 |
| Shire H2O Limited | Administrative & support | 2023 |
| Shire Plant Hire Limited | Administrative & support | 2023 |
| Shire Secure Homes Limited | Real estate | 2022 |
| Shire Toilet Hire Limited | Administrative & support | 2015 |
| Shirmar Investments Limited | Professional & scientific | 1985 |
| Shivaspace Ltd | Hospitality | 2025 |
| Shoestring Properties Ltd | Real estate | 2022 |
| Shonkworx Motorsport Ltd | Wholesale & retail | 2021 |
| Shooters Close Management Limited | Households | 2025 |
| Shooting Star Public Relations Limited | Professional & scientific | 2007 |
| Shopedeasily Ltd | Wholesale & retail | 2024 |
| Shopeeze Limited | Wholesale & retail | 2025 |
| Shoppye Trading Ltd | Wholesale & retail | 2025 |
| Shoptive Limited | Wholesale & retail | 2019 |