| SC Serenity Spaces Ltd | Hospitality | 2024 |
| SCA IT Solutions Ltd | Information & communication | 2025 |
| Scaleex Limited | Professional & scientific | 2026 |
| Scampton Defence Ltd | Public administration | 2025 |
| Scampton Developments Ltd | Extraterritorial | 2004 |
| Scandi Surgery Ltd | Health & social care | 2025 |
| Scanlinc Ltd | Health & social care | 2022 |
| Scarborough Farm Limited | Agriculture & fishing | 2018 |
| Scawthon Management Limited | Households | 2026 |
| SCC Design Ltd | Extraterritorial | 2004 |
| SCG Projects Ltd | Construction | 2019 |
| Scholey-Park Ltd | Hospitality | 2022 |
| School Attendance Plus Ltd | Education | 2022 |
| School Land Developments Limited | Construction | 2015 |
| Schroder Properties Limited | Real estate | 2023 |
| Schull Properties Limited | Real estate | 2012 |
| Scipro Consultancy Limited | Professional & scientific | 2020 |
| Scissors & Style Ltd | Other services | 2022 |
| SCK Enterprises Limited | Real estate | 2003 |
| SCK Property Enterprises Limited | Real estate | 2003 |
| Scmortgages Ltd | Financial services | 2018 |
| SCOPE123 Limited | Professional & scientific | 2021 |
| Scopesie Consulting Limited | Professional & scientific | 2022 |
| Scopwick Estates Limited | Extraterritorial | 1949 |
| Scott Kemp Anaesthetic Services Ltd | Health & social care | 2014 |
| Scott Trailers Limited | Wholesale & retail | 2009 |
| Scql Ltd | Professional & scientific | 2021 |
| SCR Group Limited | Construction | 2018 |
| Scran Man's Van Ltd | Hospitality | 2024 |
| Scriberly Limited | Information & communication | 2025 |
| SCS Property and Consulting Limited | Construction | 2026 |
| Scunthorpe Container Storage Ltd | Administrative & support | 2019 |
| SD Electrical Lincoln Limited | Construction | 2021 |
| SD Yorkshire Limited | Hospitality | 2026 |
| SDA Heritage Limited | Professional & scientific | 2025 |
| SDB Equipment Limited | Administrative & support | 2018 |
| SDC Joinery Ltd | Manufacturing | 2020 |
| SDF Development Ltd | Construction | 2026 |
| SDF Property Ltd | Construction | 2026 |
| SDG Access Limited | Manufacturing | 2004 |
| SDG UK Group Ltd | Financial services | 2026 |
| Sdgb Limited | Real estate | 2017 |
| SDL CSP Ltd | Transport & logistics | 2023 |
| SDL Logistics Limited | Transport & logistics | 2022 |
| Sdms Advisory Ltd | Administrative & support | 2023 |
| SDS Lincoln Ltd | Professional & scientific | 2022 |
| Sea Forge Ltd | Information & communication | 2026 |
| Seagreen Developments Ltd | Real estate | 2020 |
| Seagull Forwarding Ltd | Transport & logistics | 2016 |
| Seahorse Developments Ltd | Real estate | 2024 |
| Sean Cuffley Swim Coaching Ltd | Arts & recreation | 2026 |
| Searby Plant Limited | Real estate | 2018 |
| Seariously Good Ltd | Hospitality | 2025 |
| Seas (U.K) Limited | Water & waste | 2019 |
| Season-Jp Property Services Ltd | Real estate | 2026 |
| Seastar Jewellery Limited | Wholesale & retail | 2018 |
| Sebco Homes Limited | Construction | 2000 |
| Sebco Lincoln Limited | Construction | 2019 |
| Sebello Ltd | Transport & logistics | 2020 |
| Sebelo Limited | Real estate | 2017 |
| Sebster Trading Ltd | Wholesale & retail | 2014 |
| SEC Afrocaribbean Super Market Ltd | Wholesale & retail | 2025 |
| Second Issue Limited | Wholesale & retail | 2026 |
| Second Phase Ltd | Administrative & support | 2021 |
| Second Time Round Ltd | Wholesale & retail | 2026 |
| Seconda Limited | Wholesale & retail | 2025 |
| Secret Garden Investments Ltd | Real estate | 2025 |
| Secure Homes (UK) Limited | Administrative & support | 2003 |
| Secure Self Storage (South Yorkshire) Ltd | Manufacturing | 2015 |
| Secure Smart Locks Ltd | Other services | 2023 |
| Secure Storage (South Yorkshire) Limited | Real estate | 2012 |
| Secureit Consultancy Limited | Information & communication | 2024 |
| Securelocksystems Ltd | Manufacturing | 2019 |
| Security 4 (Europe) Limited | Administrative & support | 2010 |
| Securityvolt Limited | Wholesale & retail | 2024 |
| Secuviaservices Ltd | Transport & logistics | 2026 |
| Sedgwick Coaching Ltd | Information & communication | 2014 |
| Seedsology Ltd | Wholesale & retail | 2021 |
| Seeo Ltd | Information & communication | 2026 |
| Sefam Medical Ltd | Wholesale & retail | 2021 |
| Seillean Ltd | Education | 2017 |
| Select Developments (Lincoln) Limited | Real estate | 1991 |
| Select Electrical Services (Lincolnshire) Ltd | Construction | 2009 |
| Selet Limited | Real estate | 2019 |
| Self First Limited | Wholesale & retail | 2021 |
| Self Storage Newark Ltd | Real estate | 2019 |
| Selfstore 24-7 Ltd | Professional & scientific | 2016 |
| Selina Global Enterprise Ltd | Households | 2026 |
| Selletra Ltd | Wholesale & retail | 2025 |
| Selling Solution Ltd | Professional & scientific | 2024 |
| Selmec (Lincoln) Limited | Construction | 2005 |
| Selvi Thomas Ltd | Wholesale & retail | 2025 |
| Semgro Ltd | Real estate | 2024 |
| Seminal Games Limited | Manufacturing | 2019 |
| Sempers Consultancy Ltd | Professional & scientific | 2004 |
| Sempers Holdings Ltd | Financial services | 2017 |
| SEN Property Investments Limited | Real estate | 2024 |
| Sena Elwing (Lincoln) Limited | Real estate | 1999 |
| Send ARK Ltd | Education | 2023 |
| Send Love UK Ltd | Wholesale & retail | 2025 |