| Sae-Ung Ltd | Manufacturing | 2024 |
| SAF Group Enterprise Ltd | Wholesale & retail | 2025 |
| Safe Care Transport Ltd | Health & social care | 2020 |
| Safestate Consulting Ltd | Professional & scientific | 2019 |
| Safety & Environmental Consulting Ltd | Professional & scientific | 2009 |
| Safeway Recover Ltd | Transport & logistics | 2025 |
| Saffer Stretch Ltd | Professional & scientific | 2014 |
| Safi Services Ltd | Transport & logistics | 2015 |
| Saga Robotics Limited | Administrative & support | 2004 |
| Sage Social Care Limited | Health & social care | 2007 |
| Sage Street Properties Ltd | Real estate | 2024 |
| Sagehouse Holdings Ltd | Financial services | 2026 |
| Sagehouse Properties Ltd | Real estate | 2023 |
| SAGES24 Ltd | Construction | 2023 |
| Sagittar Civil Engineering Limited | Professional & scientific | 2019 |
| Saiber Management Limited | Professional & scientific | 2017 |
| Saiku Ltd | Manufacturing | 2018 |
| Saint EDI Barnabass Limited | Health & social care | 2026 |
| Sale Ltd | Wholesale & retail | 2015 |
| Saleh Gynaecare Limited | Health & social care | 2025 |
| Salesmith (Lincoln) Ltd | Professional & scientific | 2021 |
| Salisbury Caravans Ltd | Hospitality | 2017 |
| Salisbury Close Ltd | Extraterritorial | 2008 |
| Salix Hospitality Limited | Hospitality | 2025 |
| Sallisco Ltd | Wholesale & retail | 2025 |
| Sally Hubbard Limited | Extraterritorial | 2007 |
| Salon Looks Retail Limited | Other services | 2026 |
| Salon Rouge Ltd | Other services | 2006 |
| Salon Two Burton Road Limited | Other services | 2019 |
| Salt Innovations Ltd | Wholesale & retail | 2022 |
| Salted Orange Food Company Ltd. | Hospitality | 2014 |
| Salter Logistics Limited | Transport & logistics | 2024 |
| Salvatore Ladies Limited | Other services | 2002 |
| Salvatore Lincoln Limited | Other services | 2002 |
| SAM Faulkner Development Ltd | Information & communication | 2023 |
| SAM Rogers Coaching Limited | Education | 2024 |
| SAM Tech Engineering Services Limited | Professional & scientific | 1999 |
| Samantha Ford Ltd | Arts & recreation | 2025 |
| Samara Capital Ltd | Real estate | 2024 |
| Samaxia Ltd | Wholesale & retail | 2023 |
| Samba Brazil Ltd | Hospitality | 2017 |
| Samma Ajiva Limited | Information & communication | 1994 |
| Samson Dauda Ltd | Arts & recreation | 2020 |
| Samuel Cadman Homes Limited | Construction | 2014 |
| Sanctum (Lincoln) Ltd | Wholesale & retail | 2024 |
| Sandebus Limited | Real estate | 2024 |
| Sandham Engineering Services Limited | Professional & scientific | 2024 |
| Sandham Wine Merchants Ltd | Wholesale & retail | 2003 |
| Sandhill Way (Aylesbury) Freehold Company Limited | Real estate | 2006 |
| Sandilands Pigs Limited | Agriculture & fishing | 1998 |
| Sandland Taylor Consultancy LLP | | 2024 |
| Sandland-Taylor Limited | Health & social care | 2019 |
| Sandra Russell Ltd | Professional & scientific | 2025 |
| Sandrose Building Services Limited | Construction | 2023 |
| Sandrose Training Services Limited | Education | 2022 |
| Sane Insanity Limited | Wholesale & retail | 2026 |
| Sanibloc Limited | Manufacturing | 2020 |
| Sanjivini Medical Care Ltd | Health & social care | 2026 |
| Sanp Ltd | Hospitality | 2019 |
| Sansofe Ltd | Professional & scientific | 2013 |
| Santarosa Limited | Other services | 2024 |
| Santeria Consulting & Professional Ltd | Information & communication | 2025 |
| Santè Property | Wholesale & retail | 2020 |
| Santé Group Holdings Limited | Wholesale & retail | 2020 |
| Sanyal Dermatology Consultancy Ltd | Health & social care | 2018 |
| SAP Power Services Ltd | Energy | 2013 |
| Sara Allen Training Ltd | Information & communication | 2025 |
| Sara Property Limited | Real estate | 2019 |
| Sarah Clarke Consulting Ltd | Health & social care | 2023 |
| Sarah Mitchell Tree & Garden Services Limited | Administrative & support | 2015 |
| Sarah Sandy Limited | Professional & scientific | 2025 |
| Sarah Smith Software Limited | Information & communication | 2011 |
| Saral Ltd | Health & social care | 2019 |
| Sarb Property Group Ltd | Real estate | 2025 |
| Sasi Technologies Limited | Information & communication | 2018 |
| Sasian Ltd | Real estate | 2025 |
| Satherley Urology Ltd | Health & social care | 2024 |
| Sato 76 Ltd | Construction | 2018 |
| Satsuma Group Limited | Information & communication | 2017 |
| Satyanju Limited | Professional & scientific | 2014 |
| Saul Fairholm Holdings Limited | Professional & scientific | 2017 |
| Saul Fairholm Limited | Professional & scientific | 2008 |
| Sausaiwis Limited | Transport & logistics | 2016 |
| SAW Building Services (Lincoln) Ltd | Construction | 2011 |
| Saxilby Construction Ltd | Construction | 2000 |
| Saxilby Developments Ltd | Real estate | 2014 |
| Saxilby Physiotherapy Ltd | Other services | 2023 |
| Saxon Fields Management Company Limited | Other services | 2019 |
| SAY YES to ME Ltd | Transport & logistics | 2023 |
| Sayer Education Ltd | Education | 2024 |
| SB Group Developments Ltd | Construction | 2024 |
| SBC Carpets & Flooring Ltd | Construction | 2020 |
| SBG Corp Ltd | Manufacturing | 2013 |
| SBH Property Investments Limited | Real estate | 2024 |
| Sbka Lincoln Ltd | Real estate | 2025 |
| SBL Design & Engineering Limited | Real estate | 2022 |
| SBR Aviation Ltd | Administrative & support | 2022 |
| SBR Plastering and Drylining Limited | Construction | 2016 |
| SBS Architecture + Design Ltd | Professional & scientific | 2023 |
| SC Consulting 2014 Limited | Information & communication | 2014 |