| Shopybop Ltd | Wholesale & retail | 2025 |
| Shore and Dale Properties Limited | Real estate | 2020 |
| Shore Rich Ltd | Hospitality | 2018 |
| Short Ferry Leisure Ltd | Hospitality | 2024 |
| Short Stuff Services Ltd | Transport & logistics | 2025 |
| Shoulderelbowhand Ltd | Health & social care | 2026 |
| Shredmaster Limited | Water & waste | 2000 |
| SHU Xiang Yuan (UK) Ltd | Hospitality | 2016 |
| SI Training & Consulting Limited | Professional & scientific | 2008 |
| Si:Living Ltd | Manufacturing | 2025 |
| Siani PUB Co Ltd | Hospitality | 2025 |
| Sibtain Investments Ltd | Financial services | 2022 |
| Sibtain Medical Ltd | Health & social care | 2019 |
| Sickset Media Ltd | Professional & scientific | 2023 |
| Siddle Grimley Hage Limited | Professional & scientific | 2000 |
| Sideways Napoleon Ltd | Manufacturing | 2022 |
| SIG Couriers Limited | Transport & logistics | 2015 |
| Sigma Construction Consultants Limited | Construction | 2019 |
| Sigma Efficiency Limited | Wholesale & retail | 2011 |
| Sigma Living Ltd | Information & communication | 2020 |
| Sigma Management Services Limited | Construction | 2024 |
| Sign Centre (Lincoln) Limited | Administrative & support | 2006 |
| Sign Centre (Lincs) Ltd | Manufacturing | 2017 |
| Sign Lingual Ltd | Professional & scientific | 2024 |
| Signature Grace Limited | Other services | 2026 |
| Signature Health & Fitness Ltd | Arts & recreation | 2025 |
| Signature Parks Limited | Hospitality | 2014 |
| Signed 4 U Autographs LLP | | 2016 |
| Signs Direct (Lincoln) Limited | Professional & scientific | 2009 |
| Silk Plaster UK Ltd | Wholesale & retail | 2016 |
| Sills & Betteridge LLP | | 2008 |
| Sills & Betteridge Trust Corporation Limited | Administrative & support | 2024 |
| Silver Birch Skateboarding Ltd | Education | 2025 |
| Silver Darlings Ltd | Financial services | 2022 |
| Silvergate Leisure Ltd | Hospitality | 2018 |
| Silverholme Care Ltd | Real estate | 2010 |
| Silvermill Developments Limited | Real estate | 2024 |
| Simara Consultancy Services Limited | Professional & scientific | 1990 |
| Simian Consulting Limited | Education | 2022 |
| Simon and Donna Leisure Ltd | Hospitality | 2019 |
| Simon Breeden Ltd | Professional & scientific | 2021 |
| Simon Elley Interiors Ltd | Professional & scientific | 2017 |
| Simon Hawkes Ltd | Real estate | 2021 |
| Simon M Logistics Ltd | Transport & logistics | 2025 |
| Simon Machen Consulting Ltd | Extraterritorial | 2019 |
| Simon Oliver Ltd | Information & communication | 2024 |
| Simon Wild Consulting Ltd | Professional & scientific | 2018 |
| Simon Wild Picture Frames Limited | Wholesale & retail | 2018 |
| Simons Developments Limited | Construction | 2019 |
| Simpler Conveyancing Limited | Professional & scientific | 2022 |
| Simpler Law Limited | Financial services | 2016 |
| Simpler Legal Limited | Extraterritorial | 2020 |
| Simpler Life Solutions Limited | Professional & scientific | 2021 |
| Simpler Probate Limited | Other services | 2020 |
| Simpler Wills Limited | Wholesale & retail | 2020 |
| Simply Leads Limited | Information & communication | 2025 |
| Simply Reef Ltd | Wholesale & retail | 2025 |
| Simply Specs Limited | Wholesale & retail | 2009 |
| Simplystay 100 Limited | Hospitality | 2021 |
| Simplystay 101 Limited | Hospitality | 2021 |
| Simplystay 102 Ltd | Hospitality | 2022 |
| Simplystay 103 Ltd | Hospitality | 2023 |
| Simplystay 104 Ltd | Hospitality | 2025 |
| Simpson Properties Lincoln Limited | Real estate | 2022 |
| Sims Properties (Lincoln) Limited | Construction | 2004 |
| SIMUL2 Limited | Real estate | 2017 |
| Simulatology Solutions Ltd | Construction | 2019 |
| SIN Arts Ltd | Education | 2022 |
| Sinaiestatesuk Limited | Real estate | 2015 |
| Sinclair Trailers Limited | Manufacturing | 2025 |
| Single Malt Productions Ltd | Information & communication | 2021 |
| Singleton Event Services Ltd | Health & social care | 2016 |
| Singleton Training Services Ltd | Education | 2016 |
| Sinister Fish Games Ltd | Information & communication | 2018 |
| Sinner Buns Bakery Ltd | Manufacturing | 2024 |
| Sinple Franchise Ltd | Administrative & support | 2019 |
| Sinple Lincoln Ltd | Wholesale & retail | 2023 |
| SIR Robert Pattinson Academy | Education | 2011 |
| Sisucrypt Solutions Limited | Information & communication | 2025 |
| Site Courses Ltd | Education | 2020 |
| Site Storage UK Limited | Administrative & support | 2012 |
| Sitelead Ltd | Transport & logistics | 2025 |
| Sivas Catering Ltd | Hospitality | 2024 |
| Sive Medical Ltd | Health & social care | 2022 |
| SIX CS Care Ltd | Health & social care | 2018 |
| SIX Pillars Homes Ltd | Construction | 2025 |
| Sixdee Limited | Real estate | 2005 |
| Sixty Fortune Ltd | Hospitality | 2024 |
| Siyaraam Ltd | Wholesale & retail | 2022 |
| SJ Auto Tech Ltd | Wholesale & retail | 2022 |
| SJ Campion Limited | Information & communication | 2024 |
| SJC Plumbing and Bathrooms Limited | Construction | 2025 |
| SJD Financial Consulting Ltd | Professional & scientific | 2025 |
| SJE Security Ltd | Administrative & support | 2018 |
| SJH Conversion Limited | Construction | 2019 |
| SJH Flooring Ltd | Construction | 2022 |
| SJH Lincoln Limited | Wholesale & retail | 2015 |
| SJM Business Services Ltd | Administrative & support | 2012 |
| SJP Estate Holdings Ltd | Other services | 2023 |
| SJW 84 Ltd | Real estate | 2019 |