| RV Joinery Ltd | Manufacturing | 2025 |
| Rybran Blooms Ltd | Agriculture & fishing | 2019 |
| Rybran Salads Limited | Agriculture & fishing | 2014 |
| Rydel Hygiene Limited | Administrative & support | 2014 |
| Ryders Renovations & Rentals Ltd | Real estate | 2025 |
| S & D Rentals Ltd | Real estate | 2023 |
| S & M Animal Care/Housekeeping Limited | Other services | 2020 |
| S F Electrical NW Ltd | Construction | 2026 |
| S G Handling Limited | Manufacturing | 2018 |
| S Green Joinery Ltd | Construction | 2017 |
| S Harley Consultancy Limited | Financial services | 2023 |
| S Turner Heating and Plumbing Ltd | Construction | 2011 |
| S&D Dogs Limited | Other services | 2025 |
| S&L Automotive Ltd | Wholesale & retail | 2026 |
| S&P Eggs Northwest Ltd | Wholesale & retail | 2024 |
| S&P Glazing Solutions Limited | Construction | 2020 |
| S.C.Turner Forest Products Limited | Agriculture & fishing | 2017 |
| S.L.E. North West Ltd | Hospitality | 2024 |
| S.M.F Cladding Solutions Limited | Construction | 2023 |
| S4H Consulting Ltd | Administrative & support | 2013 |
| SA Languages Limited | Administrative & support | 2020 |
| SA Roofing & Sons Limited | Construction | 2025 |
| Safe Collections Limited | Financial services | 1984 |
| Safechoice Packaging Ltd | Wholesale & retail | 2014 |
| Safias Dream Desserts Ltd | Wholesale & retail | 2022 |
| Sagar Foods Ltd | Hospitality | 2012 |
| SAI Communications Limited | Administrative & support | 2017 |
| SAI TR Mart Ltd | Wholesale & retail | 2025 |
| Sales Clarity Ltd | Professional & scientific | 2021 |
| Salvation Body Rejuvenation Limited | Arts & recreation | 2024 |
| Salvation Laser Tattoo Removal Limited | Other services | 2020 |
| Salvation Studios Ltd | Arts & recreation | 2016 |
| Salwell Limited | Health & social care | 2025 |
| Sandra Ellison Property Ltd | Real estate | 2024 |
| Sandycroft Apartments Commonhold Association Ltd | Professional & scientific | 2006 |
| Sapient Master Limited | Administrative & support | 2026 |
| Sapsol Limited | Administrative & support | 2003 |
| Sarah Jane Holdings Ltd | Real estate | 2024 |
| Sarah's ARK Limited | Other services | 2003 |
| Sasha (UK) Limited | Education | 2012 |
| Satellite Group Ltd | Manufacturing | 2023 |
| Savka Enterprises Limited | Real estate | 2018 |
| SAY Two Productions C.I.C. | Education | 2002 |
| SB Developments (NW) Ltd | Real estate | 2024 |
| SB Motion Ltd | Information & communication | 2025 |
| Sbdrainage NW Ltd | Construction | 2024 |
| SC Education Ltd | Arts & recreation | 2014 |
| Scarden Group Limited | Real estate | 2020 |
| SCD Sales Ltd | Professional & scientific | 2023 |
| Scholarshifts Limited | Information & communication | 2024 |
| School Close Management Company Limited | Households | 2022 |
| School Street 1970 Limited | Extraterritorial | 2015 |
| Scma Driving School Ltd | Education | 2019 |
| Scma Football Leagues Ltd | Arts & recreation | 2025 |
| Scott Casey Logistics Ltd | Transport & logistics | 2026 |
| Scruffytofluffyboutique Ltd | Other services | 2025 |
| Sea View NW Limited | Hospitality | 2022 |
| Seagan Consultancy Limited | Information & communication | 2015 |
| Sean Pidduck Engineering Ltd | Professional & scientific | 2024 |
| Sebastian's Clinical Services Limited | Health & social care | 2012 |
| Sebastian.Care.Uk Ltd | Health & social care | 2023 |
| Secco NW Ltd | Construction | 2016 |
| Seemore Events Limited | Other services | 2019 |
| Seemore Tickets Limited | Other services | 2014 |
| Sefton Surrey Ltd | Wholesale & retail | 2025 |
| SEI Group Limited | Financial services | 2021 |
| Selborne Spring Ltd | Wholesale & retail | 2025 |
| Select Automotive Group Ltd | Wholesale & retail | 2007 |
| Selftec Services Ltd | Administrative & support | 2025 |
| Selftech Ltd | Information & communication | 2015 |
| Sempre Avanti Consulting Ltd | Financial services | 2019 |
| Sensory Street Island Ltd | Health & social care | 2025 |
| Sephton LEE Solicitors Limited | Professional & scientific | 2026 |
| SEQ Ltd | Real estate | 2018 |
| Sevens PUB Traders Ltd | Hospitality | 2025 |
| Seymour Bishop Ltd | Wholesale & retail | 2025 |
| Shadwell Ragland Ltd | Wholesale & retail | 2025 |
| Sharp Sales Solutions Ltd | Wholesale & retail | 2024 |
| Shaw & Watson Limited | Real estate | 2022 |
| Sheen's Nursery Limited | Education | 2023 |
| Sheep Hill Consultancy Ltd | Professional & scientific | 2014 |
| Shenton Mortgages Ltd | Financial services | 2025 |
| Sherman 7 Ltd | Arts & recreation | 2020 |
| Shoe Chalk Limited | Manufacturing | 2023 |
| Showmaster Holding Co Ltd | Administrative & support | 2009 |
| Showmaster Limited | Manufacturing | 1992 |
| Shrr Limited | Construction | 2025 |
| SIC Property Limited | Real estate | 2022 |
| Sidmouth Care Home Ltd | Health & social care | 2022 |
| Sidmouth Nursing Home Ltd | Health & social care | 2009 |
| Signature Spas NW Ltd | Other services | 2020 |
| Silver Birches Financial Planning Ltd | Financial services | 2019 |
| Siminki Ltd | Information & communication | 2012 |
| Simon Upton Ltd | Construction | 2024 |
| Simon-Rd Private Investments Ltd. | Real estate | 2017 |
| Singh Stores (Banister Drive) Limited | Wholesale & retail | 2017 |
| Site Consultancy 73 Ltd | Professional & scientific | 2024 |
| Sitebro Limited | Construction | 2020 |
| SJB Energy Controls Ltd | Professional & scientific | 2023 |
| SJP Holdings NW Ltd | Financial services | 2025 |