| SJP Properties NW Ltd | Real estate | 2025 |
| SJR Autoparts - Trading Ltd | Wholesale & retail | 2014 |
| SK Cars NW Ltd | Wholesale & retail | 2020 |
| SK Flawless International Ltd | Wholesale & retail | 2017 |
| Skale Talent Ltd | Administrative & support | 2021 |
| SKB Aviation Ltd | Administrative & support | 2011 |
| Sky Banner Ltd | Professional & scientific | 2021 |
| Skyfire Lasers Ltd | Administrative & support | 2019 |
| Skyfire Ltd | Administrative & support | 2025 |
| Skytech Imaging LLP | | 2020 |
| Slater's Catering & Events Ltd | Hospitality | 2024 |
| SLM Design Ltd | Professional & scientific | 2007 |
| SM Oxley Developments Ltd | Real estate | 2020 |
| Smccr Ltd | Wholesale & retail | 2011 |
| Smith J Limited | Wholesale & retail | 2026 |
| SNC86 Holdings Ltd | Professional & scientific | 2024 |
| Snowdon Star Ltd | Transport & logistics | 2020 |
| Social Forge Solutions Ltd | Professional & scientific | 2024 |
| Social Inclusion Matters Ltd | Public administration | 2021 |
| Social Quill Ltd | Information & communication | 2024 |
| Socialsbynaomi Ltd | Professional & scientific | 2026 |
| Soleada Ltd | Real estate | 2025 |
| Solicitor Direct Limited | Professional & scientific | 2013 |
| Solis Blinds Limited | Construction | 2022 |
| Solitude Solutions Limited | Manufacturing | 2023 |
| Sophia Bailey Aesthetics Ltd | Other services | 2025 |
| Soter Security Solutions Ltd | Administrative & support | 2025 |
| Sound at School Limited | Education | 2009 |
| South Manchester Skip Brokers Ltd | Other services | 2021 |
| South Ribble Garage Ltd | Wholesale & retail | 2026 |
| South Ribble GAS Services Ltd | Construction | 2024 |
| South Ribble Leisure Limited | Arts & recreation | 2021 |
| South Ribble Plastering Ltd | Construction | 2021 |
| Southbridge Holdings Ltd | Information & communication | 2025 |
| Sovereign Commercials Limited | Wholesale & retail | 2025 |
| Sovereign Transport Services Limited | Transport & logistics | 1999 |
| SP Challinor Ltd | Manufacturing | 2026 |
| SP Grounds Maintenance Ltd | Administrative & support | 2021 |
| SP Lake District Hotel Ltd | Hospitality | 2023 |
| Space to Speak Ltd | Professional & scientific | 2024 |
| SPD Automotive Limited | Wholesale & retail | 2000 |
| Special Project Resources Limited | Other services | 2017 |
| Spectrum Automation Limited | Information & communication | 2008 |
| Spectrum Clinicals Ltd | Health & social care | 2023 |
| SPH Costing Services Limited | Administrative & support | 1996 |
| Spic 'N' Span (NW) Ltd | Water & waste | 2024 |
| Splash Bathrooms and Installations Ltd | Wholesale & retail | 2022 |
| Splash Bathrooms Installations Ltd | Wholesale & retail | 2024 |
| Sportsglobal (UK) Ltd | Arts & recreation | 2009 |
| SPP Consultancy Ltd | Professional & scientific | 2026 |
| Spring Day Properties Ltd | Real estate | 2026 |
| Spring Top Group Limited | Administrative & support | 2020 |
| ST Stephen's New Ventures Limited | Real estate | 2018 |
| Stanbury Private Capital Ltd | Financial services | 2026 |
| Starlight Global Group Limited | Financial services | 2024 |
| Starlight Living and Distribution Ltd | Wholesale & retail | 2023 |
| Stationers Cove Ltd | Wholesale & retail | 2016 |
| Steak Pizza Limited | Hospitality | 2024 |
| Stealth Telematics Ltd | Wholesale & retail | 2021 |
| Steam Clean (UK) Limited | Professional & scientific | 2006 |
| Stefan-Bogdan Vesa Limited | Arts & recreation | 2025 |
| Stellar Distribution Services Limited | Transport & logistics | 2020 |
| Step Well Foot Care Ltd | Health & social care | 2025 |
| Stepete LLP | | 2015 |
| Stephen PYE Tree Services Ltd | Administrative & support | 2017 |
| Steve Blackwell Limited | Construction | 2007 |
| Steve Peddie (Consultancy Services) Limited | Professional & scientific | 2019 |
| Stockclough LLP | | 2010 |
| Stone Create Limited | Administrative & support | 2011 |
| Store IT N W Limited | Administrative & support | 2011 |
| Strutin Ltd | Manufacturing | 2026 |
| Stuart Plant Hire Limited | Construction | 2006 |
| Student Discount Vouchers Limited | Professional & scientific | 2006 |
| Studio Ashton Ltd | Professional & scientific | 2022 |
| Studio Minim Limited | Information & communication | 2024 |
| Stunell Technology Ltd | Professional & scientific | 2000 |
| Style IT Carpets (Leyland) Limited | Wholesale & retail | 2017 |
| Style Machine Tools Limited | Manufacturing | 1997 |
| Subbee Ltd | Professional & scientific | 2025 |
| Summit Conservatory Design Limited | Professional & scientific | 2004 |
| Sumners Barbers Limited | Other services | 2009 |
| Sunbury Solutions Limited | Professional & scientific | 2016 |
| Sunlumia Holidays PVT Ltd | Administrative & support | 2023 |
| Sunson Lightings Limited | Wholesale & retail | 2024 |
| Superstar Training Ltd | Arts & recreation | 2026 |
| Supreme Clean NW Ltd | Administrative & support | 2026 |
| Surftrip Limited | Extraterritorial | 2022 |
| Sustainability Suite Ltd | Professional & scientific | 2023 |
| Sustainable Gains Ltd | Other services | 2020 |
| Sutton Electrical Contractors (N.W.) Ltd. | Construction | 2002 |
| SW ADR Service Ltd | Transport & logistics | 2026 |
| SW Motorsports (UK) Ltd | Wholesale & retail | 2017 |
| SW1 Technology Limited | Other services | 2025 |
| Swain Dog Limited | Arts & recreation | 2019 |
| Sweat & Sculpt SOC. Ltd | Arts & recreation | 2024 |
| Swift Properties NW Ltd | Real estate | 2013 |
| Swifty Ltd | Other services | 2026 |
| Switch Inc Ltd | Other services | 2025 |
| Syriana Food Ltd | Wholesale & retail | 2019 |
| Szakacs Lorand Tattoo Ltd | Arts & recreation | 2020 |