| Skin Medic Solutions Limited | Health & social care | 2018 |
| Skinology Pro Devices Limited | Wholesale & retail | 2025 |
| Skipsrus North West Ltd | Water & waste | 2025 |
| Skyline Kitchen Components Ltd | Wholesale & retail | 2021 |
| Skyline Kitchen Solutions Ltd | Wholesale & retail | 2026 |
| Skyrise Installations Limited | Construction | 2017 |
| Slab Space Ltd | Wholesale & retail | 2025 |
| Slatestones Property Solutions Limited | Other services | 2024 |
| Sleigh Ltd | Manufacturing | 2010 |
| Slyzone UK Limited | Administrative & support | 2016 |
| Sm@Rt BUS Limited | Construction | 2019 |
| Sm@Rt Technology Ltd | Construction | 2019 |
| Sm@Rt Train Limited | Manufacturing | 2020 |
| Small Scale Limited | Construction | 2021 |
| Smart Barber BA Limited | Other services | 2025 |
| Smart Tech Recycling Ltd | Wholesale & retail | 2015 |
| Smartness Ltd | Wholesale & retail | 2019 |
| SMW Flooring Ltd | Construction | 2016 |
| Snack Odyssey Ltd | Wholesale & retail | 2025 |
| Snack Savage Ltd | Wholesale & retail | 2021 |
| Snowsport England Limited | Arts & recreation | 1980 |
| Social Impact Token Limited | Professional & scientific | 2024 |
| Social Kite Ltd | Professional & scientific | 2018 |
| Soho Housing Group Limited | Financial services | 2020 |
| Soho JV1 Limited | Construction | 2022 |
| Soho JV2 Limited | Construction | 2022 |
| Soho JV3 Limited | Construction | 2022 |
| Sol-Air Conditioning Ltd | Energy | 2024 |
| Solarfilm Sales Limited | Manufacturing | 2010 |
| Solution Profiling Limited | Information & communication | 2000 |
| Somi's Patisserie & Cafe Limited | Hospitality | 2016 |
| Sophie Anne Aesthetics Limited | Other services | 2022 |
| South Ribble Physiotherapy Ltd | Health & social care | 2011 |
| Southern Express Retail Ltd | Wholesale & retail | 2025 |
| SP Bowers Consultancy Ltd | Professional & scientific | 2015 |
| Spa Tubs Hire Ltd | Administrative & support | 2021 |
| Spar Benllech Limited | Wholesale & retail | 2026 |
| Spark Body Repair Ltd | Wholesale & retail | 2020 |
| Sparrow 13 Ltd | Financial services | 2025 |
| SPD Trans Ltd | Transport & logistics | 2025 |
| Spechaus Ltd | Wholesale & retail | 2025 |
| Specialist Insolvency Support Services Ltd | Financial services | 2019 |
| Specialist Motor Services Limited | Wholesale & retail | 2024 |
| Sphere Connect Limited | Professional & scientific | 2016 |
| Spice Lounge Leigh Ltd | Hospitality | 2026 |
| Spidge Sussex Limited | Professional & scientific | 2025 |
| Spirit Motor Company Limited | Wholesale & retail | 2010 |
| Splash Hand Car Wash Limited | Administrative & support | 2019 |
| SPM 2 Limited | Administrative & support | 2019 |
| Sport Wellbeing and Education Limited | Financial services | 2020 |
| Sporting Club Leigh Limited | Arts & recreation | 2002 |
| Sportivity Consultancy Ltd | Professional & scientific | 2021 |
| Sportivity Limited | Arts & recreation | 2006 |
| Spot on Accounts Limited | Professional & scientific | 2014 |
| Spot-On Interior Finishes Ltd | Construction | 2018 |
| Spring-Gate Ltd | Manufacturing | 2019 |
| Spva Limited | Manufacturing | 2021 |
| SRD Supplies Ltd | Wholesale & retail | 2024 |
| ST Framework Building and Joinery Ltd | Construction | 2025 |
| Staffordshire Works Limited | Professional & scientific | 2010 |
| Stag Property Management Ltd | Real estate | 2020 |
| Stakd Ltd | Real estate | 2021 |
| Stamford RD Property Ltd | Real estate | 2024 |
| Stanhope Street Limited | Construction | 2022 |
| Star Convenience (PVT) Store Limited | Hospitality | 2018 |
| Starfex Limited | Wholesale & retail | 2024 |
| Starkicks Ltd | Education | 2026 |
| Stars Properties (MCR) Limited | Real estate | 2020 |
| Stat Magazine Limited | Information & communication | 2024 |
| Stayshieldgroup Limited | Wholesale & retail | 2025 |
| Steel Detailing Professionals Index Ltd | Other services | 2026 |
| Steve Briggs High Speed Supplies Ltd | Transport & logistics | 2024 |
| Steve Jackson Consulting Limited | Financial services | 2001 |
| Stitch - Rite Limited | Manufacturing | 1999 |
| Stockops Ltd | Information & communication | 2025 |
| Stone Classics Ltd | Construction | 2023 |
| Stone Valley Work Surfaces Limited | Manufacturing | 2024 |
| Storytellergraphic Ltd | Health & social care | 2021 |
| Stour Road 1970 Limited | Extraterritorial | 2014 |
| STR Engineering Limited | Professional & scientific | 2026 |
| Straight Ledger Bookkeeping & Accountancy Limited | Professional & scientific | 2025 |
| Strata Nest Limited | Construction | 2025 |
| Stricker's Ltd | Wholesale & retail | 2019 |
| Strides Veterinary Services Ltd | Professional & scientific | 2021 |
| Structural Testing Ltd | Professional & scientific | 2023 |
| Structures (Jolley) Group Ltd | Construction | 2020 |
| Structures Consult Limited | Professional & scientific | 2023 |
| Structures Holdings Limited | Financial services | 2019 |
| Structures Housing Limited | Construction | 2016 |
| Structures Pointing Limited | Construction | 2018 |
| Structures Renovations (Pike) Limited | Construction | 2022 |
| Struktura Engineering Services Limited | Construction | 2015 |
| Struktura Holdings Limited | Other services | 2025 |
| Studio PTD Ltd | Information & communication | 2025 |
| Stuff Galore Ltd | Wholesale & retail | 2025 |
| Styrene Solutions Limited | Professional & scientific | 2023 |
| Subport Group Ltd | Professional & scientific | 2023 |
| Subsea Chemistry Limited | Manufacturing | 2015 |
| Subsea Fluid Services Limited | Professional & scientific | 2012 |
| Subsea Fluids Group Limited | Professional & scientific | 2015 |