| Ruvees Ltd | Real estate | 2024 |
| RW Decor Ltd | Wholesale & retail | 2026 |
| Ryel Group Ltd | Wholesale & retail | 2025 |
| S & P Property Law Limited | Professional & scientific | 2024 |
| S a Kendall Fireplace Fitters Ltd | Construction | 2014 |
| S and L Marketing Limited | Administrative & support | 2015 |
| S G Menswear Limited | Wholesale & retail | 2011 |
| S R Harris TM Ltd | Construction | 2024 |
| S R Waite Electrical Contractors Ltd | Construction | 1996 |
| S R Waite Group Ltd | Construction | 2019 |
| S Trading UN Ltd | Transport & logistics | 2026 |
| S&G Building Contractors Limited | Construction | 2020 |
| S. Carden Systems Limited | Manufacturing | 1981 |
| S.L Enterprises (PVT) Ltd | Wholesale & retail | 2025 |
| Safe Anchor Therapy Limited | Health & social care | 2025 |
| Safe Choice Couriers Limited | Transport & logistics | 2025 |
| Saframac Management Limited | Real estate | 2019 |
| Sakhi Lajpal Ltd | Wholesale & retail | 2025 |
| Salcon NW Limited | Construction | 2024 |
| Sale & Save Ltd | Other services | 2025 |
| Salon 22 Ltd | Other services | 2022 |
| Sammy Healthcare Limited | Health & social care | 2015 |
| Samuel & Abimbola Ltd | Health & social care | 2025 |
| Samvic Ltd | Health & social care | 2022 |
| Sandbrook Leisure Limited | Arts & recreation | 2010 |
| Santo's Health and Fitness Ltd | Arts & recreation | 2021 |
| Sapphire Care Support Services CIC | Health & social care | 2025 |
| Sapphire Homecare Ltd | Public administration | 2022 |
| Sapphire Homecare Yorkshire Ltd | Health & social care | 2023 |
| Sapphire Residential Care Home Ltd | Health & social care | 2022 |
| Sara Foodstore Ltd | Wholesale & retail | 2025 |
| Sarra.K Ltd | Information & communication | 2021 |
| SAS Automotive Group Ltd | Wholesale & retail | 2025 |
| SAS2 Business Services Limited | Information & communication | 2014 |
| Save & Shop Mini Market Leigh Ltd | Wholesale & retail | 2025 |
| SB Nation Wide Scaffolding Ltd | Construction | 2025 |
| Sbamford Consulting Limited | Professional & scientific | 2021 |
| Sc-Pt Coaching Ltd | Education | 2022 |
| SCA Properties Ltd | Real estate | 2018 |
| School of Aesthetics Ltd | Education | 2019 |
| Scott Properties (NW) Limited | Real estate | 2016 |
| Scrap Trade Centre Limited | Water & waste | 2013 |
| Screenstretch Ltd | Manufacturing | 2000 |
| Scriptacular Limited | Information & communication | 2014 |
| SE Ltd | Real estate | 2024 |
| Seafreshuk Ltd | Hospitality | 2024 |
| Seat Academy Limited | Manufacturing | 2021 |
| Seatree Site Services Limited | Construction | 2025 |
| Secure Gates Services Limited | Construction | 2022 |
| Sedco (Northwest) Limited | Wholesale & retail | 1991 |
| Sedco Holdings Limited | Financial services | 2024 |
| Sedco Limited | Manufacturing | 1981 |
| Selanica Propaints Ltd | Construction | 2023 |
| Select Meals Ltd | Hospitality | 2023 |
| Sell Your Goods Ltd | Wholesale & retail | 2026 |
| Seraphinent Ltd | Wholesale & retail | 2025 |
| Service Geeni Ltd | Information & communication | 2017 |
| Severn Street Limited | Extraterritorial | 2014 |
| SFV Design Ltd | Construction | 2025 |
| SG Dental Laboratory Limited | Manufacturing | 2023 |
| SG Tree Care Ltd | Construction | 2021 |
| Sglh Ltd | Real estate | 2024 |
| SH Design Consultancy Limited | Professional & scientific | 2012 |
| Shamrock Properties 2024 Ltd | Construction | 2024 |
| Shane.Hurst.Events Ltd | Arts & recreation | 2025 |
| Shaun Donnellan Ltd | Administrative & support | 2022 |
| Shawarma Palace Leigh Ltd | Hospitality | 2023 |
| Shell Drainage Ltd | Water & waste | 2020 |
| Shepherd Lifestyle Concierge Limited | Other services | 2018 |
| Sherratts Wood Community Interest Company | Health & social care | 2012 |
| Shiraz Cafe & Grill Ltd | Hospitality | 2025 |
| Shirley & Shirley Holdings Ltd | Real estate | 2025 |
| Shoes Retail Ltd | Wholesale & retail | 2013 |
| Shopinityart Ltd | Wholesale & retail | 2025 |
| Shweta Ltd | Health & social care | 2021 |
| Shwetabhi Holding Ltd | Financial services | 2026 |
| SI Señor Productions Ltd | Information & communication | 2025 |
| Side Healthcare Enterprises Ltd | Health & social care | 2024 |
| Sienna Rose Investments Limited | Administrative & support | 2018 |
| Sierra Lima Leigh Limited | Arts & recreation | 2017 |
| Sigma Transport&Co Ltd | Transport & logistics | 2024 |
| Sigoesglobal Ltd | Administrative & support | 2026 |
| Silcock & Sargent Limited | Wholesale & retail | 2023 |
| Simaxx Analytics Ltd. | Information & communication | 2020 |
| Simon Goldberg Limited | Extraterritorial | 2023 |
| Simon John Goldberg Limited | Extraterritorial | 2023 |
| Simply Bearings Limited | Wholesale & retail | 2005 |
| Simply Green Turfing Specialists Ltd | Administrative & support | 2025 |
| Simpson Holdings NW Ltd | Financial services | 2024 |
| Sims Brickwork Ltd | Construction | 2018 |
| Simtech Education Ltd | Education | 2021 |
| Siniori Club Ltd | Wholesale & retail | 2025 |
| Site Enabling Services Limited | Construction | 2022 |
| Sizzlers Leigh Limited | Hospitality | 2025 |
| SJB Quality Consulting Ltd | Professional & scientific | 2022 |
| Sjhuk Ltd | Wholesale & retail | 2026 |
| SJO Printing Limited | Manufacturing | 2025 |
| SJS Vehicle Delivery Service Limited | Transport & logistics | 2014 |
| SJT Property Investment Ltd | Real estate | 2018 |
| Skills 4 Life NW Ltd | Education | 2024 |