| Speedy Cleanings Limited | Other services | 2019 |
| Speedy Express Logistics Limited | Transport & logistics | 2019 |
| Speedy Food Ltd | Hospitality | 2019 |
| Speedy Homes Ltd | Real estate | 2026 |
| Speedy Sells Ltd | Wholesale & retail | 2025 |
| Spencefield Cabs Ltd | Transport & logistics | 2024 |
| Spencer & Co Mortgage Specialists Ltd | Financial services | 2022 |
| Spencer & Sons Construction Ltd | Construction | 2013 |
| Spencer + MO. Ltd | Professional & scientific | 2018 |
| Spencer BA Consulting Services Ltd | Information & communication | 2025 |
| Spencer Getliffe Associates Limited | Professional & scientific | 2025 |
| Spencer Porter Ltd. | Construction | 2003 |
| Spencers Druce Limited | Extraterritorial | 1986 |
| Spencers Inns Limited | Hospitality | 2017 |
| Spencerton Holdings Group Ltd | Financial services | 2025 |
| Spenders Recruitment Consultants Limited | Administrative & support | 2017 |
| Spero Ultrasound Services Limited | Health & social care | 2009 |
| Sperry Property Ltd | Real estate | 2023 |
| Spesa Express Ltd | Wholesale & retail | 2025 |
| SPF Management Solutions Ltd | Administrative & support | 2016 |
| Sphere Capital Limited | Real estate | 2021 |
| Spherico Ventures (UK) Limited | Administrative & support | 2023 |
| SPI Holdings Limited | Real estate | 2002 |
| Spice 45 Ltd | Hospitality | 2025 |
| Spice and Soul Ltd | Hospitality | 2024 |
| Spice Balti House Leicester Ltd | Hospitality | 2026 |
| Spice Capital Restaurant Ltd | Hospitality | 2019 |
| Spice Catering Services Ltd | Hospitality | 2025 |
| Spice Central Limited | Wholesale & retail | 2024 |
| Spice Dinning Limited | Hospitality | 2025 |
| Spice Direct Ltd | Hospitality | 2019 |
| Spice Express (Cleobury) Limited | Hospitality | 2015 |
| Spice in the Box Limited | Manufacturing | 2007 |
| Spice Mart Ltd | Wholesale & retail | 2020 |
| Spice Masala Ltd | Hospitality | 2025 |
| Spice Planet Ltd | Wholesale & retail | 2018 |
| Spice Route Leicester Ltd | Hospitality | 2022 |
| Spice-N-Tice Limited | Manufacturing | 2005 |
| Spiced Kitchen Limited | Hospitality | 2024 |
| Spicewok Limited | Hospitality | 2018 |
| Spick and Span Cleaning (Leicester) Ltd | Administrative & support | 2022 |
| Spicy Style (Leicester) Ltd | Hospitality | 2017 |
| Spider Bigo Ltd | Other services | 2022 |
| Spidercrab Limited | Financial services | 2015 |
| Spidron Tech U.K. Ltd | Information & communication | 2021 |
| Spiers (Leicester) Ltd | Real estate | 2006 |
| Spigots Ltd | Administrative & support | 2015 |
| Spikey Productions Ltd | Arts & recreation | 2013 |
| Spin & Precession Limited | Public administration | 2024 |
| Spin Echo Limited | Manufacturing | 2020 |
| Spineye Ltd | Health & social care | 2025 |
| Spinney (Glen Parva) Management Company Limited | Households | 1982 |
| Spinney Hill Recovery House CIC | Health & social care | 2018 |
| Spinney Hill Taxis Ltd | Transport & logistics | 2023 |
| Spinney Meadows Limited | Households | 2019 |
| Spinney Yarns Ltd | Wholesale & retail | 2013 |
| Spiral Bowlfeeders Limited | Administrative & support | 2017 |
| Spiral Driving School Limited | Education | 2024 |
| Spirit Academy of Dance CIC | Arts & recreation | 2024 |
| Spirit at Play Ltd | Health & social care | 2014 |
| Spirit Clinical Services Limited | Health & social care | 2012 |
| Spirit Consulting (UK) Ltd | Health & social care | 2007 |
| Spirit Digital Ltd | Health & social care | 2018 |
| Spirit Electrical Ltd | Construction | 2020 |
| Spirit Health Group EBT Limited | Extraterritorial | 2018 |
| Spirit Health Group Ltd | Wholesale & retail | 2014 |
| Spirit Health Property Ltd | Real estate | 2021 |
| Spirit Healthcare Ltd | Wholesale & retail | 2007 |
| Spirit Home Care Limited | Health & social care | 2014 |
| Spirit Implement Limited | Professional & scientific | 2010 |
| Spirit Kits Ltd | Wholesale & retail | 2022 |
| Spirit MED Ltd | Wholesale & retail | 2015 |
| Spirit Pharmacy Limited | Wholesale & retail | 2018 |
| Spirit Primary Care Limited | Health & social care | 2022 |
| Spiritlab Holding Ltd | Administrative & support | 2021 |
| Spiritual-Gypsy Limited | Other services | 2018 |
| Spiritualq Limited | Administrative & support | 2019 |
| Spirvin UK Limited | Real estate | 2026 |
| Spitfire Artist Management Limited | Professional & scientific | 2020 |
| SPJ Foods UK Ltd | Hospitality | 2021 |
| SPK Lettings Ltd | Real estate | 2023 |
| SPK Medical Services Ltd | Administrative & support | 2015 |
| SPK Pharma Ltd | Wholesale & retail | 2018 |
| Spkd Properties Limited | Real estate | 2017 |
| Splash & Snack Co Ltd | Hospitality | 2026 |
| Splash Fashion Ltd | Manufacturing | 2019 |
| Splash Graphix Ltd | Professional & scientific | 2008 |
| Splash Spa and Leisure Limited | Other services | 2013 |
| Splash Spa Limited | Other services | 2018 |
| Splendental Care Limited | Health & social care | 2025 |
| Splendid Technology Ltd | Manufacturing | 2026 |
| Split Image Creative International Limited | Wholesale & retail | 2025 |
| Spmp Ltd | Arts & recreation | 2025 |
| Spondon Dental Ltd | Health & social care | 2013 |
| Spooley Limited | Information & communication | 2012 |
| Spoon JAR Films Limited | Manufacturing | 2014 |
| Spooner Hoole Ltd | Wholesale & retail | 2025 |
| Spoox Components Limited | Wholesale & retail | 2004 |
| Spoox Motorsport Ltd | Wholesale & retail | 2007 |
| Spoox Racing Developments Limited | Wholesale & retail | 2019 |