| Spa Express Limited | Administrative & support | 2025 |
| Space & Node Ltd | Wholesale & retail | 2026 |
| Space Place Limited | Real estate | 2021 |
| Space Planning and Consultancy in Education Limited | Extraterritorial | 2012 |
| SPACE4U Counselling Ltd | Education | 2021 |
| Spacearc Studio Ltd | Professional & scientific | 2026 |
| Spacewearx UK Limited | Professional & scientific | 2025 |
| Spacex Renovations Ltd | Construction | 2025 |
| Spain Consulting LP | | 2017 |
| Spalding Bede Ltd | Wholesale & retail | 2025 |
| Spalford Leisure Park Ltd | Hospitality | 2018 |
| Spalford Ltd | Transport & logistics | 2015 |
| Spandan Ltd | Wholesale & retail | 2023 |
| Spanner Wheels Limited | Wholesale & retail | 2026 |
| Spannersonwheels Ltd | Wholesale & retail | 2025 |
| Spar Serena Two Limited | Wholesale & retail | 2014 |
| Sparbaruk Ltd | Extraterritorial | 2013 |
| Sparco Limited | Transport & logistics | 2018 |
| Spark by UD Limited | Hospitality | 2026 |
| Spark Drinks Ltd | Manufacturing | 2024 |
| Spark Estates Ltd | Real estate | 2017 |
| Spark Sweep Services Ltd | Construction | 2024 |
| Sparkbrook Best Ltd | Transport & logistics | 2014 |
| Sparked Potential Ltd | Professional & scientific | 2025 |
| Sparkenhoe Holdings Ltd | Professional & scientific | 2021 |
| Sparkford Optimum Ltd | Transport & logistics | 2015 |
| Sparkle and Shine Cleaning Services Ltd | Extraterritorial | 2024 |
| Sparkle Crafts Limited | Wholesale & retail | 2017 |
| Sparkle Domestic and Industrial Cleaning Services Limited | Other services | 2011 |
| Sparkle Event Styling Limited | Professional & scientific | 2025 |
| Sparkle My Business Ltd | Administrative & support | 2023 |
| Sparkle My Home Ltd | Administrative & support | 2017 |
| Sparkle Sister Cleaning Ltd | Administrative & support | 2026 |
| Sparkle With Glow Limited | Extraterritorial | 2024 |
| Sparkles & Shine Cleaning Services Ltd | Administrative & support | 2026 |
| Sparklight Cleaning Ltd | Administrative & support | 2024 |
| Sparkod Limited | Administrative & support | 2026 |
| Sparks Design Limited | Information & communication | 2002 |
| Sparktechuk Ltd | Information & communication | 2024 |
| Sparkzelectricalslc Ltd | Construction | 2024 |
| Sparrow (Leicester) Limited | Wholesale & retail | 2009 |
| Sparrow Shetton Ltd | Wholesale & retail | 2024 |
| Sparsis Estates Ltd | Real estate | 2021 |
| Spartan Doors Ltd | Manufacturing | 2024 |
| Spartan Waste Limited | Water & waste | 2022 |
| Spaw Engineering Limited | Manufacturing | 1965 |
| SPD Enterprise Limited | Wholesale & retail | 2023 |
| SPE General Ltd | Health & social care | 2024 |
| Speadoo Catering Ltd | Hospitality | 2012 |
| Speake Compliance Ltd | Professional & scientific | 2023 |
| Specc Automotive Limited | Wholesale & retail | 2023 |
| Specc Detailing Limited | Wholesale & retail | 2023 |
| Speccy Media Limited | Information & communication | 2021 |
| Speceyes Limited | Health & social care | 2017 |
| Special Force Security Limited | Public administration | 2025 |
| Special Projects (Cleveland Street) Limited | Real estate | 2018 |
| Special Vehicle Rentals Limited | Administrative & support | 2022 |
| Specialised Courses Offering Purposeful Education Limited | Education | 1990 |
| Specialist Blade Company Ltd | Wholesale & retail | 1988 |
| Specialist Cars Holdings Limited | Professional & scientific | 2007 |
| Specialist Cars Limited | Wholesale & retail | 1989 |
| Specialist Cars Property (Stevenage) Limited | Real estate | 2007 |
| Specialist Cars Tring Limited | Wholesale & retail | 2008 |
| Specialist Contract Management Services Limited | Professional & scientific | 2019 |
| Specialist Crafts Leicester Limited | Wholesale & retail | 1991 |
| Specialist Crafts Limited | Wholesale & retail | 2000 |
| Specialist Sportswear Limited | Professional & scientific | 1982 |
| Specialist Surgical Services Ltd | Health & social care | 2008 |
| Speciality Care (Medicare) Limited | Professional & scientific | 1994 |
| Speciality Care (Rest Homes) Limited | Health & social care | 1995 |
| Speciality Care Limited | Professional & scientific | 1993 |
| Speciality Recruitment Limited | Administrative & support | 2017 |
| Spectra-Tek UK Limited | Professional & scientific | 1984 |
| Spectrum Build Ltd | Construction | 2022 |
| Spectrum Construction Ltd | Construction | 2024 |
| Spectrum Education Consultancy Ltd | Education | 2016 |
| Spectrum IT Limited | Information & communication | 2023 |
| Spectrum Sensory Sports CIC | Arts & recreation | 2021 |
| Spectrum Shoes Limited | Manufacturing | 2002 |
| Spectrum Travel Ltd | Administrative & support | 2018 |
| Spectrum Vapes Limited | Wholesale & retail | 2019 |
| Spectrum Ventures Ltd | Hospitality | 2021 |
| Spectrumcbm Limited | Administrative & support | 2004 |
| Spectus Healthcare Ltd | Public administration | 2023 |
| Speech Therapy With ANI Ltd | Health & social care | 2022 |
| Speed Aloe & Clothing Limited | Wholesale & retail | 2014 |
| Speed Enterprise Limited | Financial services | 2005 |
| Speed Global Trade Ltd | Wholesale & retail | 2021 |
| Speed Import Car Sales Ltd | Wholesale & retail | 2025 |
| Speed Packaging Limited | Administrative & support | 2004 |
| Speed Properties Limited | Real estate | 2015 |
| Speed Sales Motorcycles Ltd | Wholesale & retail | 2025 |
| Speedage PVT Ltd | Transport & logistics | 2025 |
| Speedel Group Limited | Financial services | 2022 |
| Speedel Ltd | Transport & logistics | 2017 |
| Speedline Prestige Travel Limited | Transport & logistics | 2018 |
| Speedy Bargains Limited | Wholesale & retail | 2024 |
| Speedy BOT Limited | Wholesale & retail | 2017 |
| Speedy Car Service Ltd | Wholesale & retail | 2025 |
| Speedy Chef Limited | Manufacturing | 2025 |