| Sport in Desford Trading Limited | Administrative & support | 2003 |
| Sport Massage Leicester Ltd | Health & social care | 2016 |
| Sport Support Leicester Ltd | Wholesale & retail | 2020 |
| Sportgrid Limited | Information & communication | 2025 |
| Sportiii Analytics Ltd | Arts & recreation | 2019 |
| Sporting Birstall Limited | Arts & recreation | 2026 |
| Sporting Capers Leicester Ltd | Administrative & support | 2018 |
| Sportline Car Sales Limited | Wholesale & retail | 2015 |
| Sports & Medical Bracing UK Ltd | Wholesale & retail | 2013 |
| Sports Fusion Ventures Limited | Education | 2024 |
| Sports Leisure Ltd | Administrative & support | 2020 |
| Sports Logic Group UK CIC | Education | 2023 |
| Sports Massage Therapy Ltd | Arts & recreation | 2023 |
| Sports Surfaces (Leicester) Limited | Construction | 2003 |
| Sports Therapy Exercise & Massage Limited | Health & social care | 2023 |
| Sports-Rock&Pop Designer Masks Ltd | Manufacturing | 2020 |
| Sportsequip.Co.Uk (Leics) Limited | Transport & logistics | 2005 |
| Sportsman Manchester Ltd | Wholesale & retail | 2019 |
| Spot-Dec Limited | Wholesale & retail | 2020 |
| Spotless Elegance Ltd | Real estate | 2024 |
| SPP Couriers Ltd | Transport & logistics | 2019 |
| SPP Health Ltd | Wholesale & retail | 2019 |
| SPP Investments Limited | Extraterritorial | 2017 |
| Sppe Ltd | Other services | 2019 |
| Spratton Food & Wine Ltd | Wholesale & retail | 2024 |
| Spray Booth Service & Filtration Limited | Professional & scientific | 2017 |
| Spraybooth Maintenance and Supplies Limited | Administrative & support | 2003 |
| Spraycair Limited | Manufacturing | 2013 |
| Sprayforce (UK) Limited | Manufacturing | 2015 |
| Spraynelly Coatings Limited | Construction | 2026 |
| Spreadpay Ltd | Financial services | 2018 |
| Spree Enterprise Ltd | Wholesale & retail | 2025 |
| Spree Properties Limited | Construction | 2003 |
| Sprigbest Limited | Hospitality | 1986 |
| Spriggan Games Ltd | Professional & scientific | 2026 |
| Sprime Limited | Wholesale & retail | 2026 |
| Spring Artbooks Ltd | Wholesale & retail | 2023 |
| Spring Box Commercial Cleaning Ltd | Administrative & support | 2019 |
| Spring Educational Society (SES) | Education | 2005 |
| Spring Gardens BA Management Co Ltd | Households | 2024 |
| Spring Jade Limited | Financial services | 2018 |
| Spring Lettings Ltd | Real estate | 2021 |
| Spring Property Solutions Ltd | Real estate | 2019 |
| Spring Rock Developments Limited | Real estate | 2012 |
| Spring Shades Holdings Limited | Financial services | 2013 |
| Spring Shades Lettings Ltd | Real estate | 2024 |
| Spring Shades Limited | Manufacturing | 1994 |
| Springbok Enterprise Solutions Ltd | Information & communication | 2004 |
| Springfield Hill Investments Ltd | Real estate | 2008 |
| Springfield Pressings Limited | Manufacturing | 1974 |
| Springfield Stores Long Eaton Limited | Wholesale & retail | 2017 |
| Springfields Advisory LLP | | 2016 |
| Springhill Care Group Limited | Professional & scientific | 1998 |
| Springhill House (Accrington) Limited | Health & social care | 1987 |
| Springwell Metals Ltd | Wholesale & retail | 2024 |
| Sprite Contracts Limited | Construction | 1998 |
| SPS (Leicester) Limited | Construction | 2023 |
| SPS Digital & Technology Consulting Limited | Information & communication | 2021 |
| SPS Enterprise Ltd | Information & communication | 2023 |
| SPS Investments Limited | Real estate | 2009 |
| SPS Technologies Limited | Manufacturing | 1935 |
| Spst Property Investments Ltd | Real estate | 2022 |
| Spud BUS Ltd | Hospitality | 2026 |
| Spudfellas Limited | Hospitality | 2025 |
| SPY Properties Ltd | Real estate | 2021 |
| SPY UAV Ltd | Manufacturing | 2025 |
| Spyder Developments Ltd | Real estate | 2017 |
| Spyder Holdings Limited | Real estate | 2022 |
| Spyder Investments Ltd | Real estate | 2012 |
| SQ & Sons Ltd | Information & communication | 2016 |
| SQL Blitz Limited | Information & communication | 2013 |
| Squad Inc Ltd | Information & communication | 2020 |
| Square & Beauty Ltd | Other services | 2024 |
| Square Mile Outdoors Limited | Construction | 2023 |
| Square One Leisure Limited | Professional & scientific | 2019 |
| Square Pizza Belgrave Limited | Hospitality | 2022 |
| Square Pizza Blaby Ltd | Hospitality | 2024 |
| Square Residentials Ltd | Real estate | 2021 |
| Square RIG Limited | Manufacturing | 2014 |
| Squarebox Estates Ltd | Real estate | 2025 |
| Squarecube Architecture Ltd | Professional & scientific | 2021 |
| Squeakies Nursery and Pre-School Ltd | Education | 2015 |
| Squeekz Cleaning Services Ltd | Administrative & support | 2025 |
| Squifford Media Limited | Arts & recreation | 2017 |
| Squire Equestrian Limited | Administrative & support | 2009 |
| Squirecom Limited | Other services | 2008 |
| Squires Logistics Limited | Transport & logistics | 2003 |
| Squirrel Distribution Ltd | Financial services | 2018 |
| SR 2410 Limited | Information & communication | 2025 |
| SR Autos Leicester Ltd | Wholesale & retail | 2026 |
| SR Building Developers Ltd | Construction | 2024 |
| SR Car Leicester Ltd | Wholesale & retail | 2025 |
| SR Collection Ltd | Wholesale & retail | 2021 |
| SR Construction & Maintenance Ltd | Construction | 2023 |
| SR Convenience Store Ltd | Wholesale & retail | 2019 |
| SR Cosmetics Ltd | Wholesale & retail | 2024 |
| SR Countesthorpe Ltd | Construction | 2022 |
| SR Dermatology Ltd | Health & social care | 2023 |
| SR Engineering (Leicester) Limited | Construction | 2013 |
| SR Hair Lounge Ltd | Other services | 2025 |