| South Wales Vending Services Limited | Extraterritorial | 1995 |
| South Yorkshire Breast Educational Meeting Ltd | Education | 2026 |
| South Yorkshire Pensions Authority Fund KCP 1 L.P. | | 2007 |
| South Yorkshire Property Developments Limited | Wholesale & retail | 1984 |
| Southall Sage Ltd | Administrative & support | 2023 |
| Southalls Property Ltd | Hospitality | 2022 |
| Southbrook GAS Generation Limited | Construction | 2019 |
| Southern African Academy of Pharmacy CIC | Education | 2021 |
| Southern Cross Property Ltd | Real estate | 2021 |
| Southern Waterlilies Investment Limited | Real estate | 2023 |
| Southfield (Dalton) Management Company Limited | Households | 2019 |
| Southfield Yorkshire Limited | Real estate | 2025 |
| Southfold Medical Limited | Health & social care | 2013 |
| Southgate House Ltd | Professional & scientific | 2011 |
| Southgate Properties (Wakefield) Limited | Real estate | 1958 |
| Southland Consultancy Services Limited | Information & communication | 2025 |
| Southlands Close Maintenance Limited | Households | 1962 |
| Southlands Road Ltd | Real estate | 2025 |
| Southleigh (Headingley) Management Limited | Real estate | 1992 |
| Southleigh Developments Limited | Real estate | 2025 |
| Southmead Properties Ltd | Real estate | 2020 |
| Southside Music Limited | Real estate | 1994 |
| Southview Limited | Real estate | 2025 |
| Southwest Associates Ltd | Hospitality | 2024 |
| Southwind Developments Limited | Real estate | 2004 |
| Souvenir MS Limited | Administrative & support | 2013 |
| Souvlaki Leeds Ltd | Hospitality | 2024 |
| Souvlaki Morley Ltd | Hospitality | 2025 |
| Sovereign Advisory LLP | | 2009 |
| Sovereign Air Movement Limited | Wholesale & retail | 2000 |
| Sovereign Asset Solutions Limited | Professional & scientific | 2015 |
| Sovereign Assets & Developments Ltd | Real estate | 2015 |
| Sovereign BI, Data and Analytics Ltd | Information & communication | 2018 |
| Sovereign Bothy Limited | Wholesale & retail | 2025 |
| Sovereign Commercial Estates Ltd | Real estate | 2017 |
| Sovereign Consultancy Services Limited | Professional & scientific | 1961 |
| Sovereign Estates and Developments Limited | Real estate | 2013 |
| Sovereign Fitness Ltd | Arts & recreation | 2023 |
| Sovereign Homes and Developments Ltd | Real estate | 2018 |
| Sovereign Hospital Services Limited | Health & social care | 1996 |
| Sovereign Life Group Ltd | Financial services | 2024 |
| Sovereign Life Group Services Ltd | Financial services | 2025 |
| Sovereign Management Solutions Limited | Construction | 2017 |
| Sovereign True Solutions LLP | | 2025 |
| Sovereign Trustees Limited | Financial services | 2001 |
| Sovereign Wealth Holdings Ltd | Financial services | 2022 |
| Sovereign Wealth Limited | Financial services | 2010 |
| Soyar Ltd | Real estate | 2025 |
| Sozele Ltd | Wholesale & retail | 2025 |
| Sozo Clinic Ltd | Health & social care | 2023 |
| Sozo Global Limited | Public administration | 2022 |
| Sozo Healthcare Ltd | Health & social care | 2024 |
| SP Car Care Limited | Wholesale & retail | 2019 |
| SP Certification Limited | Other services | 2018 |
| SP Dreams Ltd | Real estate | 2016 |
| SP Executive Recruitment Limited | Administrative & support | 2023 |
| SP Financial Planning Limited | Financial services | 2010 |
| SP Graham Holdings Limited | Professional & scientific | 2020 |
| SP Graham Homes Limited | Real estate | 2019 |
| SP Graham Investments Limited | Financial services | 2020 |
| SP Hair and Scalp Clinic Ltd | Other services | 2025 |
| SP Holdings (Yorkshire) Limited | Financial services | 2022 |
| SP Management Consultancy Ltd | Information & communication | 2014 |
| SP Manufacturing Services Limited | Financial services | 2015 |
| SP Motors Leeds Ltd | Wholesale & retail | 2024 |
| SP Odyssey Ltd | Financial services | 2025 |
| SP86 Ltd | Real estate | 2024 |
| Spa Buildings (Harrogate) Limited | Administrative & support | 2015 |
| Spa ICT Services Ltd | Other services | 2008 |
| Spa Town Properties Ltd | Real estate | 2024 |
| Spa Valeting Ltd | Administrative & support | 2026 |
| Space Developments (Yorkshire) Limited | Manufacturing | 2017 |
| Space Hire Limited | Real estate | 2019 |
| Space Kraft (Holdings) Limited | Professional & scientific | 2015 |
| Space Kraft International Limited | Wholesale & retail | 2009 |
| Space Leasing International Asset Company Limited | Other services | 2023 |
| Space Leasing International Management Company Limited | Other services | 2023 |
| Space North Consulting Limited | Professional & scientific | 2025 |
| Space Real Estate Solutions Limited | Real estate | 2023 |
| Space Regen Ltd | Construction | 2024 |
| SPACE2 Leeds | Health & social care | 2003 |
| Spaced OUT Events and Promotions Ltd | Arts & recreation | 2025 |
| Spacedent Ltd | Health & social care | 2018 |
| Spacehunter Ltd | Real estate | 2022 |
| Spaces by Equinox Limited | Professional & scientific | 2021 |
| Spacliff Properties Ltd | Extraterritorial | 2017 |
| Spacliff Property Investments Limited | Real estate | 1999 |
| Spadh Group Limited | Wholesale & retail | 2025 |
| Spadina Limited | Professional & scientific | 2003 |
| Spaghetti Assets Ltd | Professional & scientific | 2013 |
| Span Investments LLP | | 2026 |
| Spanish UK Holdings Limited | Professional & scientific | 2015 |
| Spard Ltd | Wholesale & retail | 2021 |
| Spark Casper Holdings Limited | Administrative & support | 2024 |
| Spark Commercial Cleaning Limited | Administrative & support | 2024 |
| Spark Design Services Ltd | Information & communication | 2014 |
| Spark Energy Supply Ltd | Energy | 2006 |
| Spark Escapes Ltd | Other services | 2015 |
| Spark Healthcare Limited | Health & social care | 2015 |
| Spark Market Research (UK) Limited | Financial services | 2021 |