| Spark Medical Limited | Health & social care | 2016 |
| Spark People Solutions Ltd | Administrative & support | 2020 |
| Spark Primary Care Ltd | Professional & scientific | 2023 |
| Spark Vehicle Solutions Ltd | Wholesale & retail | 2022 |
| Sparkcleaning Services Yorkshire Limited | Administrative & support | 2023 |
| Sparkes Recruitment Limited | Administrative & support | 2019 |
| Sparkle and Dust Ltd | Administrative & support | 2024 |
| Sparkle and Shine (Leeds) Limited | Administrative & support | 2016 |
| Sparkleaning Leeds Ltd | Administrative & support | 2020 |
| Sparkleen Commercial Limited | Other services | 2012 |
| Sparkles Cleaning Solutions Ltd | Administrative & support | 2026 |
| Sparkling N Shining Ltd | Administrative & support | 2016 |
| Sparks Confectioners Limited | Manufacturing | 1970 |
| SPARKY2DAY Limited | Construction | 2024 |
| Sparq Live Limited | Administrative & support | 2018 |
| Sparrow Gate Property Limited | Real estate | 2024 |
| Sparta Court Management Company Limited | Households | 2021 |
| Spartan Financial Solutions Limited | Financial services | 2014 |
| Spartan Mechanical Services Ltd | Construction | 2021 |
| Spartan Resin Design Ltd | Construction | 2021 |
| Spartan Resin Ltd | Construction | 2025 |
| Spartansuperiorproducts Ltd | Wholesale & retail | 2023 |
| Spartec Mechanical & Electrical Ltd | Construction | 2025 |
| Sparwash Limited | Other services | 2014 |
| Sparwave Limited | Real estate | 1994 |
| Spatial EX Ltd | Information & communication | 2021 |
| Spatial Initiative Limited | Construction | 2017 |
| Spatialized Limited | Other services | 2010 |
| Spatialtrifecta Limited | Administrative & support | 2024 |
| Spatzwear Custom Limited | Manufacturing | 2026 |
| Spatzwear Limited | Manufacturing | 2017 |
| Spawforth Rolinson Holdings Limited | Professional & scientific | 2003 |
| Spawforth Rolinson Limited | Professional & scientific | 1988 |
| Spawforths EOT Limited | Financial services | 2024 |
| Spayce Corporation Limited | Information & communication | 2025 |
| SPC (Lomond Court) Limited | Real estate | 2006 |
| SPC Wright IT Ltd | Information & communication | 2019 |
| SPD Electrical Ltd | Construction | 2015 |
| SPE 366 Ltd | Professional & scientific | 2023 |
| SPE Mktg Ltd | Professional & scientific | 2023 |
| SPE Simpson Ltd | Professional & scientific | 2020 |
| Speak Consulting Limited | Administrative & support | 2022 |
| Speak IT Into Being Ltd | Professional & scientific | 2016 |
| Speak Woman Speak C.I.C. | Arts & recreation | 2023 |
| Speakers Circle Ltd | Education | 2024 |
| Spear Group Holdings Limited | Manufacturing | 1999 |
| Spear Limited | Financial services | 2023 |
| Spearguard Limited | Transport & logistics | 2019 |
| Spearhavoc Limited | Professional & scientific | 2009 |
| Spec- Truck Ltd | Wholesale & retail | 2019 |
| Specdums Limited | Real estate | 2024 |
| Special Electrics Ltd | Construction | 2019 |
| Special Motors Ltd | Wholesale & retail | 2019 |
| Specialist Auto Solutions Ltd | Wholesale & retail | 2023 |
| Specialist Concrete Products Limited | Manufacturing | 2020 |
| Specialist Contract Cleaning Limited | Professional & scientific | 2002 |
| Specialist Glazing Installations UK Ltd | Construction | 2021 |
| Specialist Insulation Solutions Limited | Construction | 2017 |
| Specialist Laminates Ltd | Construction | 2013 |
| Specialist Mining Services Limited | Wholesale & retail | 1989 |
| Specialist Operational Security Ltd | Other services | 2019 |
| Specialist Performance Parts Ltd | Extraterritorial | 2019 |
| Specialist Procurement Services Finance Limited | Professional & scientific | 2024 |
| Specialist Procurement Services Limited | Professional & scientific | 2016 |
| Specialist Property Investments UK Ltd | Real estate | 2026 |
| Specialist Recruitment Solutions Limited | Administrative & support | 2020 |
| Specialist Tiling Supplies Limited | Wholesale & retail | 2010 |
| Specialist Trailer Hire Limited | Administrative & support | 1998 |
| Specialist Travel (Ireland) Limited | | 1981 |
| Specialist Vehicle Purchasing Ltd | Administrative & support | 2022 |
| Specific Creative Ltd | Information & communication | 2014 |
| Specify Search Ltd | Administrative & support | 2021 |
| Spectacledbear Ltd | Professional & scientific | 2020 |
| Spectatus Ltd | Professional & scientific | 2015 |
| Spector Financial Services Ltd | Professional & scientific | 2016 |
| Spectra Rehabilitation Services Ltd | Health & social care | 2018 |
| Spectra Software Systems Limited | Information & communication | 2024 |
| Spectrasys Technologies Ltd | Information & communication | 2023 |
| Spectre & Stone Ltd | Construction | 2025 |
| Spectre Industrial Holdings Limited | Professional & scientific | 2016 |
| Spectre SJ Properties Limited | Real estate | 2021 |
| Spectrographic Limited | Administrative & support | 2001 |
| Spectronic Camspec Limited | Wholesale & retail | 2008 |
| Spectrum CS Ltd | Administrative & support | 2024 |
| Spectrum Plant Limited | Administrative & support | 2009 |
| Spectrum Steel Services Ltd | Manufacturing | 2010 |
| Speech Engineering Limited | Administrative & support | 2013 |
| Speed Awareness Limited | Professional & scientific | 2010 |
| Speed ENI Limited | Transport & logistics | 2025 |
| Speed Haulage & Transport Limited | Transport & logistics | 2015 |
| Speed Sandu Ltd | Transport & logistics | 2025 |
| Speed Spray Jets Limited | Administrative & support | 2024 |
| SPEED2MARKET Ltd | Extraterritorial | 2024 |
| Speedex 247 Ltd | Transport & logistics | 2023 |
| Speedfreak Ltd | Transport & logistics | 2019 |
| Speedoux Ltd | Wholesale & retail | 2022 |
| Speeds Holdings | Financial services | 1962 |
| Speedsteppers Ltd | Professional & scientific | 2018 |
| Speedwayhealth Ltd | Wholesale & retail | 2018 |
| Speedwell Dance CIC | Arts & recreation | 2026 |