| Soothingproducts Ltd | Wholesale & retail | 2011 |
| SOP Healthcare Services Ltd | Other services | 2017 |
| Sopam Properties Ltd | Construction | 2023 |
| Sophisticated Property Possibilities Ltd | Real estate | 2024 |
| Sophotechnion Ltd | Professional & scientific | 2025 |
| Soprano LS14 Ltd | Hospitality | 2018 |
| Sora Living Online Ltd | Wholesale & retail | 2026 |
| Sorai Holdings Limited | Wholesale & retail | 2019 |
| Sorai International Limited | Professional & scientific | 2019 |
| Sorelle Hartley Ltd | Administrative & support | 2017 |
| Soremi Jewellery Limited | Manufacturing | 2014 |
| Sorial Associates Ltd | Administrative & support | 2026 |
| Sorkin Brown Limited | Real estate | 2021 |
| Sorrell Homes Limited | Wholesale & retail | 1936 |
| Sorrento Leeds Limited | Hospitality | 2019 |
| Sorrisso Ltd | Hospitality | 2019 |
| Sort to FIX Ltd | Other services | 2025 |
| Sorted Media UK Limited | Manufacturing | 2009 |
| Sorted NON Fault Accident Management Ltd | Wholesale & retail | 2026 |
| SOS Group Holdings Limited | Financial services | 2024 |
| SOS Marketing Ltd | Professional & scientific | 2020 |
| Sosa Finance Ltd | Information & communication | 2026 |
| Sostratus Energy Limited | Manufacturing | 2024 |
| Sostratus Technologies Limited | Professional & scientific | 2024 |
| Sota Training Ltd | Professional & scientific | 2013 |
| Sotano Limited | Hospitality | 2012 |
| Sotralentz (U.K.) Limited | Manufacturing | 1985 |
| Soul Ad-Venture Group Ltd | Financial services | 2026 |
| Soul Ad-Venture Property Ltd | Real estate | 2026 |
| Soul ARK Ltd | Health & social care | 2025 |
| Soul Beauty Ltd | Other services | 2025 |
| Soul Techie Ltd | Information & communication | 2024 |
| Soulman Tradind Company Limited | Health & social care | 2015 |
| Soulton Orchards Ltd | Financial services | 2026 |
| Sound 20 20 Publishing Limited | Administrative & support | 2001 |
| Sound Action Limited | Hospitality | 2008 |
| Sound Activity Ltd | Hospitality | 2002 |
| Sound Bites Ltd | Hospitality | 2025 |
| Sound Branch Limited | Professional & scientific | 2016 |
| Sound Channel Limited | Administrative & support | 2011 |
| Sound Concerts Limited | Arts & recreation | 2011 |
| Sound Dept. Limited | Professional & scientific | 2008 |
| Sound Leisure Holdings Limited | Financial services | 2016 |
| Sound Malta LLP | | 2014 |
| Sound Proof Box Community Interest Company | Arts & recreation | 2021 |
| Sound Sense Respite and Entertainment Limited | Health & social care | 2002 |
| Soundblast Limited | Administrative & support | 2000 |
| Soundproof Recordings Ltd | Information & communication | 2006 |
| Soundshield Limited | Wholesale & retail | 2018 |
| Soundworks AV Limited | Administrative & support | 2025 |
| Souqminal Ltd | Wholesale & retail | 2026 |
| Source & Delight Limited | Wholesale & retail | 2024 |
| Source ANY Car Limited | Wholesale & retail | 2013 |
| Source by Design Limited | Administrative & support | 2006 |
| Source Connect Consulting Limited | Administrative & support | 2013 |
| Source Connect UK Limited | Administrative & support | 2019 |
| Source Marketing Communications Limited | Professional & scientific | 2002 |
| Source Sport Limited | Wholesale & retail | 2009 |
| Source Sustainable Supply Chains Limited | Wholesale & retail | 2011 |
| Sourcebrew Ltd | Information & communication | 2024 |
| Sourced Leeds Ltd | Real estate | 2020 |
| Sourced Property Ltd | Hospitality | 2021 |
| Sourced&Supplied Ltd | Wholesale & retail | 2025 |
| Sourcing and Importing Consultancy Services Ltd | Professional & scientific | 2024 |
| Sourcing Investments Ltd | Professional & scientific | 2015 |
| South & East Leeds General Practice Group Limited | Health & social care | 2015 |
| South Acre Aviation Limited | Professional & scientific | 2011 |
| South Asian Arts-Uk | Education | 1997 |
| South Bridge Properties LLP | | 2012 |
| South Coast Insulation Services Limited | Construction | 2010 |
| South Coast Ventilation Limited | Construction | 2019 |
| South East Cars Leeds Ltd | Transport & logistics | 2022 |
| South Elmsall Cafe Ltd | Hospitality | 2024 |
| South Elmsall FNC Ltd | Hospitality | 2024 |
| South END Gardens LLP | | 2022 |
| South END Properties Limited | Construction | 2024 |
| South Herts Waste Management Limited | Arts & recreation | 1992 |
| South Indian Restaurants Ltd | Hospitality | 2013 |
| South IT East IT Ltd | Information & communication | 2017 |
| South Kirkby Energy Limited | Energy | 2024 |
| South Leeds Alternative Trading Enterprise Limited | Wholesale & retail | 2007 |
| South Leeds C.I.C. | Education | 2018 |
| South Leeds Car Valeting Ltd | Administrative & support | 2025 |
| South Leeds Community Club Limited | Hospitality | 2024 |
| South Leeds Data Limited | Information & communication | 2025 |
| South Leeds Estates Ltd | Real estate | 2021 |
| South Leeds Hand Car Wash Ltd | Administrative & support | 2022 |
| South Leeds Life C.I.C. | Information & communication | 2016 |
| South Leeds Removals Ltd | Transport & logistics | 2025 |
| South Leeds Sofa Ltd | Wholesale & retail | 2022 |
| South London Dog Training Ltd | Other services | 2022 |
| South Manchester Dental Emergency Cooperative Limited | Health & social care | 2019 |
| South Milford Preschool Ltd | Health & social care | 2023 |
| South Parade Estates Ltd | Real estate | 2012 |
| South Parade Properties Limited | Real estate | 1989 |
| South Park Road II Limited | Real estate | 2021 |
| South Park Road Limited | Real estate | 2015 |
| South Shropshire Consultancy Ltd | Information & communication | 2018 |
| South Tyneside Contractors Limited | | 1980 |
| South View Transport Ltd | Transport & logistics | 2025 |