| Spagroservices Ltd | Agriculture & fishing | 2022 |
| Spaned Ltd | Professional & scientific | 2023 |
| Spanish Food Solutions Limited | Wholesale & retail | 2006 |
| Sparbar IQ Limited | Information & communication | 2026 |
| Sparkenhoe Properties Limited | Administrative & support | 1970 |
| Sparklemuffins Soft Play Limited | Administrative & support | 2024 |
| Sparreux Limited | Administrative & support | 2016 |
| Sparta Tooling Ltd | Manufacturing | 2021 |
| Specialist Car Sales Ltd | Wholesale & retail | 2024 |
| Specialist Mobility Training Limited | Wholesale & retail | 2007 |
| Spectrumkod Ltd | Information & communication | 2021 |
| Spektra Motors Ltd | Wholesale & retail | 2025 |
| Spencer Gill Developments Limited | Construction | 2022 |
| Spernal Farms Limited | Agriculture & fishing | 2005 |
| SPG Medical Ltd | Health & social care | 2024 |
| Spice Village Eathorpe Ltd | Hospitality | 2026 |
| Spirits With Stories Limited | Wholesale & retail | 2021 |
| SPL Warwick Limited | Construction | 2012 |
| Sponge Hammer Ltd | Information & communication | 2016 |
| Sportshub Coaching Limited | Education | 2015 |
| SPP Homes Limited | Real estate | 2019 |
| Sprightly Homes Limited | Real estate | 2024 |
| Springfield Lakes Limited | Real estate | 1999 |
| Sprinng Limited | Wholesale & retail | 2026 |
| Sprog DCC Limited | Manufacturing | 2015 |
| Sproul Partners Limited | Professional & scientific | 2005 |
| Squab Holding Limited | Financial services | 2012 |
| Squab Limited | Administrative & support | 2012 |
| Squab Personnel Limited | Other services | 2006 |
| Squab Removals Limited | Transport & logistics | 2020 |
| Squab Storage Bridgwater Limited | Administrative & support | 2023 |
| Squab Storage Stowmarket Limited | Administrative & support | 2022 |
| Square 9 (Europe) Ltd | Wholesale & retail | 2017 |
| Square Coffee Rugby Ltd | Hospitality | 2019 |
| Square Service Ltd | Administrative & support | 2026 |
| Squidge Pubs Ltd | Hospitality | 2022 |
| Squire Building and Property Maintenance Limited | Construction | 2020 |
| Squirrel Market Limited | Hospitality | 2014 |
| SR Healthcare Limited | Health & social care | 2016 |
| SRN Midlands Associates Limited | Professional & scientific | 2017 |
| Srpi Limited | Real estate | 2017 |
| SRS Race Developments Ltd | Manufacturing | 2023 |
| SS Hothi Limited | Health & social care | 2011 |
| SSG Electrical Service Limited | Manufacturing | 2014 |
| SSL Co 1 Ltd | Real estate | 2019 |
| SSL Co Holdings Limited | Financial services | 2023 |
| SSL Equestrian Limited | Agriculture & fishing | 2017 |
| SSS Partners Limited | Real estate | 2023 |
| ST Bernards Limited | Professional & scientific | 2007 |
| ST George's Business Park Management Company Ltd | Households | 2014 |
| ST Mary's Road House Ltd | Other services | 2021 |
| ST Nicholas Consultancy Ltd | Professional & scientific | 2025 |
| ST Property Investments Ltd | Real estate | 2017 |
| ST Raphael the Archangel Catholic Multi-Academy Trust | Education | 2014 |
| ST. Andrews Vale Limited | Professional & scientific | 2021 |
| ST. Christopher's Publishing Limited | Information & communication | 2004 |
| ST. James's Hotel (Arundel) Limited | Hospitality | 2014 |
| ST. James's Hotel (Cambridge) Limited | Hospitality | 2014 |
| ST. James's Hotel (Winchester) Limited | Hospitality | 2014 |
| ST. James's Hotel Financing Limited | Financial services | 2014 |
| ST. James's Hotel Group Limited | Professional & scientific | 2014 |
| ST. James's Hotel Management Limited | Hospitality | 2014 |
| ST. James's Hotel Properties Limited | Real estate | 2014 |
| ST. James's Hotel Trading (Bath) Limited | Hospitality | 2015 |
| ST. James's Hotel Trading (Stratford) Limited | Hospitality | 2015 |
| ST. James's Hotel Trading Limited | Real estate | 2019 |
| ST. James’S Hotel (Sussex) Limited | Real estate | 2017 |
| ST. Paul's Square Properties Limited | Construction | 1970 |
| STA Adrian Toma Limited | Manufacturing | 2015 |
| Stacey Construction & Development Limited | Construction | 2019 |
| Stadiarena Solutions Limited | Arts & recreation | 2015 |
| Stadium Productions Ltd | Information & communication | 2015 |
| Stamford Asset Management Limited | Households | 2024 |
| Stancescu Ltd | Professional & scientific | 2017 |
| Stanley Close (Chipping Norton) Management Company Ltd | Households | 2018 |
| Starley Consultancy Limited | Information & communication | 1999 |
| Starr Property Solutions Ltd | Professional & scientific | 2022 |
| Stars Given Ltd | Manufacturing | 2026 |
| Start With the END Ltd | Professional & scientific | 2025 |
| Station View Court Management Ltd | Construction | 2019 |
| Status London International Limited | Extraterritorial | 2016 |
| Status London Limited | Professional & scientific | 2014 |
| Status Menswear Limited | Wholesale & retail | 2012 |
| Staunton Procurement Consulting Ltd | Professional & scientific | 2026 |
| STC Flourish Ltd | Transport & logistics | 2020 |
| Steane Energy Services Limited | Professional & scientific | 2012 |
| Steane Group Limited | Extraterritorial | 2015 |
| Steel PAN Academy | Education | 2006 |
| Stefanto Ltd | Hospitality | 2026 |
| Sterling Electrical Ltd | Construction | 2016 |
| Sterrey Ltd | Information & communication | 2016 |
| Steve Breakwell Ltd | Professional & scientific | 2009 |
| Steve Evans Consulting Limited | Professional & scientific | 2017 |
| Steve Jackson Wood Works Ltd | Manufacturing | 2025 |
| Steve Mccarthy Property Limited | Real estate | 2025 |
| Steve Sandher Photography Ltd | Professional & scientific | 2024 |
| Steveay Limited | Professional & scientific | 2017 |
| Stevens Research Limited | Professional & scientific | 2001 |
| Stewart Aitken Property Management Ltd | Real estate | 2020 |
| Stirrup & Lead Ltd | Wholesale & retail | 2024 |