| SKS Professional Services Limited | Professional & scientific | 2026 |
| Sky IT Limited | Administrative & support | 2010 |
| Skyden Limited | Real estate | 2019 |
| Skye Inc Limited | Professional & scientific | 2018 |
| Skyline Accountancy Services Limited | Professional & scientific | 2016 |
| Slabb Chocolate Limited | Wholesale & retail | 2017 |
| Slam Property Group Limited | Real estate | 2022 |
| Slate Art Gallery Ltd | Wholesale & retail | 2017 |
| Slate Studios Ltd | Information & communication | 2015 |
| Slick Implementations Ltd | Information & communication | 2017 |
| Slick Pixel Ltd | Information & communication | 2022 |
| Slinky Sofa Tables Ltd | Administrative & support | 2017 |
| Slorach Houses Limited | Real estate | 2021 |
| Slow Horses Property Ltd | Real estate | 2024 |
| SLP Civil Engineering Ltd | Construction | 2022 |
| SLS Trading Group Limited | Construction | 2025 |
| Slshop (Sales & Service) Ltd | Wholesale & retail | 2006 |
| Smack Leamington Limited | Hospitality | 2019 |
| Small Business Marketing Ltd | Manufacturing | 2014 |
| Smallsky Creative Ltd | Information & communication | 2024 |
| Smart Agent Pro Limited | Information & communication | 2025 |
| Smart Microtech Ltd | Extraterritorial | 2019 |
| Smartily Ltd | Education | 2023 |
| Smiffs Garage Ltd. | Wholesale & retail | 2015 |
| Smith & Abel Developments Ltd | Construction | 2022 |
| Smith & Edwards Solutions Limited | Real estate | 2014 |
| Smith and Abel Ltd | Construction | 2016 |
| Smoking GUN Vintage Limited | Wholesale & retail | 2023 |
| Smowkhaus Ltd | Hospitality | 2020 |
| Smudgy Ltd | Information & communication | 2026 |
| Smuffy Properties Limited | Real estate | 2016 |
| SN Group Ltd | Wholesale & retail | 2023 |
| Snaffskates Limited | Wholesale & retail | 2023 |
| SNB Logistics Ltd | Transport & logistics | 2019 |
| Snoozy Greyhound Ltd | Information & communication | 2023 |
| Snshomesolutions Limited | Extraterritorial | 2022 |
| Soccer Pots Limited | Information & communication | 2019 |
| Socio CAP Ltd | Professional & scientific | 2020 |
| Soft Shell Ltd | Hospitality | 2024 |
| Software Growth Partners Limited | Professional & scientific | 2023 |
| Softwarely Ltd | Information & communication | 2021 |
| Sohal Direct Ltd | Wholesale & retail | 2018 |
| SOL Three Limited | Professional & scientific | 2025 |
| Solace Springs Care Ltd | Health & social care | 2021 |
| Solaris Real Estate Limited | Construction | 2023 |
| Solarix-Nrg Limited | Professional & scientific | 2024 |
| Solid SEB Ltd | Construction | 2026 |
| Solihull Landscapes Ltd | Administrative & support | 2025 |
| Solitech Limited | Information & communication | 2002 |
| Soltechsupply Ltd | Manufacturing | 2022 |
| Solution Team Limited | Information & communication | 2004 |
| SOLUTION8 Business Services Limited | Professional & scientific | 2016 |
| Solvedhr Limited | Administrative & support | 2015 |
| Some Events Limited | Extraterritorial | 2010 |
| Someone Creative LLP | | 2015 |
| Somerset Press Ltd | Information & communication | 1989 |
| Somerville Arms Ltd | Hospitality | 2002 |
| Son&Hut Limited | Hospitality | 2024 |
| Sonder Associates Ltd | Administrative & support | 2021 |
| Sonya Burke Consulting Limited | Professional & scientific | 2022 |
| Sootbusters Limited | Other services | 1997 |
| Sophie BEE Enterprises Ltd | Arts & recreation | 2010 |
| Sophie Purewal Ltd | Extraterritorial | 2013 |
| SOT Consultancy Limited | Professional & scientific | 2016 |
| Soul Assembly Holdings Ltd | Financial services | 2022 |
| Soul Assembly Ltd | Information & communication | 2020 |
| Soul Purpose Limited | Information & communication | 2014 |
| Soul Rise Leamington C.I.C. | Health & social care | 2026 |
| Soul-Status Ltd | Health & social care | 2018 |
| Source Fieldwork Ltd | Professional & scientific | 2018 |
| Source Lingerie Limited | Arts & recreation | 2009 |
| South Bucks Estates Limited | Extraterritorial | 2015 |
| South Lynn House Limited | Construction | 2024 |
| South Town Events CIC | Administrative & support | 2024 |
| South VIC Carpark Ltd | Households | 2017 |
| South Warwickshire Electrical Services Ltd | Manufacturing | 2015 |
| Southam Developments Limited | Construction | 2016 |
| Southam Saddles Limited | Wholesale & retail | 2012 |
| Southam Services Limited | Construction | 2004 |
| Southbrook Estates Limited | Professional & scientific | 2013 |
| SP-1 Design Ltd | Professional & scientific | 2012 |
| Spa Brickwork (Leamington) Ltd | Construction | 2020 |
| Spa Cars Limited | Wholesale & retail | 2025 |
| Spa Dairy Limited | Wholesale & retail | 2003 |
| Spa Estates Lettings Limited | Real estate | 2023 |
| Spa Fire & Security Solutions Ltd | Administrative & support | 2016 |
| Spa IP & Consulting Limited | Professional & scientific | 2014 |
| Spa JET Wash Ltd | Administrative & support | 2023 |
| Spa Motors Ltd | Wholesale & retail | 2001 |
| Spa Pressure Washing Limited | Administrative & support | 2017 |
| Spa Publishing Group Ltd | Information & communication | 2024 |
| Spa Sash Joinery Limited | Manufacturing | 2018 |
| Spa Sash Windows Limited | Construction | 2017 |
| Spa Store CV31 Ltd | Wholesale & retail | 2025 |
| Spa Trophies Limited | Wholesale & retail | 2019 |
| Spa Tyres Limited | Wholesale & retail | 2012 |
| Space Healthcare Limited | Health & social care | 2012 |
| Space London Limited | Professional & scientific | 2020 |
| Space UK Construction Limited | Construction | 2023 |
| Spaco Limited | Construction | 2013 |