| Domell Plumbing Limited | Construction | 2007 |
| Done & Dusted Southport Limited | Households | 2006 |
| Donpride Limited | Professional & scientific | 1979 |
| Dougie Tobutt Limited | Wholesale & retail | 2003 |
| Douglas Lewis Ltd | Financial services | 2021 |
| Douglass Grange Limited | Professional & scientific | 1996 |
| DPB Signalling Ltd | Construction | 2016 |
| DPG Properties (NW) Ltd | Real estate | 2004 |
| DR Fiona Sutcliffe Limited | Administrative & support | 2007 |
| Dreamspace Construction Limited | Construction | 2007 |
| Drilling Engineering Consultancy Services Limited | Extraterritorial | 2003 |
| Driver Supplier Ltd. | Professional & scientific | 2008 |
| Drome Storage Company Limited | Transport & logistics | 1961 |
| Dryden Cowper Ltd | Wholesale & retail | 2025 |
| DTR (Rossendale) Limited | Real estate | 1997 |
| DTR Property Solutions Limited | Real estate | 2025 |
| Ducklings Day Nurseries Limited | Education | 2007 |
| Duckworths Estate Agents Limited | Real estate | 2003 |
| Duddy Godlonton Limited | Extraterritorial | 1999 |
| Dukefield Foodservice Limited | Hospitality | 2003 |
| Dukefield Print Solutions Limited | Wholesale & retail | 2004 |
| Dukefield Procurement Limited | Professional & scientific | 2000 |
| Duncan Raistrick Estate Agents Blackpool Limited | Administrative & support | 2008 |
| Dunham Investments Limited | Real estate | 2003 |
| Dunkley Construction Limited | Wholesale & retail | 1994 |
| Dunloy Land Limited | Construction | 2024 |
| Dunphy Combustion Limited | Manufacturing | 1971 |
| Dunphy Technology Limited | Professional & scientific | 2002 |
| Dunstone Ltd | Transport & logistics | 2007 |
| Duoworks (UK) Ltd | Information & communication | 2001 |
| Dustmat Rental Limited | Administrative & support | 1992 |
| DWY Gloch Investments Limited | Other services | 1963 |
| Dybex Limited | Wholesale & retail | 2024 |
| Dyluc Limited | Real estate | 2003 |
| Dynahurst Limited | Construction | 1982 |
| Dynanti LLP | | 2007 |
| E Gillibrand Ltd | Hospitality | 2003 |
| E K Holdings Limited | Professional & scientific | 1998 |
| E Reeder and Sons Limited | Construction | 2005 |
| E-Learning Developments Limited | Information & communication | 2006 |
| E-Nigmer Ltd. | Information & communication | 2000 |
| E-Tec Housing 1 Ltd | Real estate | 2024 |
| E.L.B. Interior Decor Limited | Construction | 2001 |
| E.N.B. Properties Limited | Real estate | 2000 |
| E.R. Blaskey Limited | Other services | 2001 |
| E.S.K. Industrial Roofing Limited | Construction | 1995 |
| E.T.Electrical Contractors Ltd | Construction | 2003 |
| E.V.T.S. Ltd | Extraterritorial | 2001 |
| Eafield & Maple Lettings Limited | Real estate | 2007 |
| Early Start Performing Arts Ltd | Arts & recreation | 2005 |
| East Lancashire Railway Holdings Company Limited | Transport & logistics | 2004 |
| Eastfield Electrical Services Limited | Construction | 2008 |
| Easthams Florists Ltd | Wholesale & retail | 2006 |
| Eastland Estates Ltd | Financial services | 1998 |
| Eastwood Contractors Limited | Construction | 1999 |
| EBM Contracts Limited | Construction | 2007 |
| Ebony Shoe Designs Limited | Real estate | 2002 |
| Ebusiness UK Limited | Information & communication | 1998 |
| Echoshare Limited | Real estate | 1988 |
| Edge Accountants Limited | Professional & scientific | 2007 |
| Edge Hill Enterprises Limited | Administrative & support | 1990 |
| Edge Hill Property Services Limited | Administrative & support | 1996 |
| Edgeway Heating Limited | Construction | 2006 |
| Edlo Investments Limited | Real estate | 1961 |
| Edmara Limited | Construction | 2005 |
| Education Supplies Direct.Com Limited | Professional & scientific | 2003 |
| Edward Hall Limited | Manufacturing | 1901 |
| Edwards Derbyshire Plastering Contractors Ltd | Construction | 2007 |
| Edwards Developments (Marton) Ltd | Construction | 2007 |
| EEI (UK) Limited | Manufacturing | 2004 |
| Effective Control Ltd | Professional & scientific | 2007 |
| Effin Records Limited | Arts & recreation | 2002 |
| Egans Drainage Services Limited | Water & waste | 2004 |
| Eggville Ltd | Extraterritorial | 2007 |
| Eight Industrial (Winnington) Limited | Construction | 2020 |
| Eight Industrial (Wrexham 2) Limited | Construction | 2020 |
| Eight Industrial (Wrexham 4) Limited | Construction | 2020 |
| Elec-Tek Wigan Limited | Construction | 2003 |
| Electrical Distribution Supplies Limited | Wholesale & retail | 1996 |
| Elgin Elms Ltd | Wholesale & retail | 2025 |
| Elgin Hotel Limited | Hospitality | 1970 |
| Elite Auto Bodyshop Ltd | Wholesale & retail | 2007 |
| Elite Electrical Design Services Ltd | Professional & scientific | 1993 |
| Elite Lockers Limited | Manufacturing | 1995 |
| Elite Rentals (Bolton) Limited | Wholesale & retail | 2003 |
| Elite Storage Limited | Real estate | 1997 |
| Elle Nine Limited | Other services | 2004 |
| Ellerslie Fold Management Co. Ltd | Households | 1998 |
| Elliot Mcdonald Limited | Professional & scientific | 2005 |
| Elliot's Electrical Contractors Limited | Construction | 2004 |
| Elmhurst Construction Limited | Construction | 2005 |
| Elmprint Limited | Manufacturing | 1995 |
| Elton Electrical Supplies (NW) Ltd | Real estate | 2004 |
| Elton Sail Ltd | Wholesale & retail | 2025 |
| Elwood Estates Holdings Ltd | Construction | 2025 |
| Emanuel Whittaker Holdings Limited | Construction | 2004 |
| Embro-Print Limited | Manufacturing | 2003 |
| Emerald Upholstery Limited | Manufacturing | 2000 |
| Emergency Systems Limited | Wholesale & retail | 2001 |
| Emma Hartley Bridalwear Limited | Wholesale & retail | 2005 |