| SEABLUE7 Limited | Administrative & support | 2019 |
| Search-Online-Now Ltd | Manufacturing | 2019 |
| Searchlight Finance Ltd | Financial services | 2012 |
| Selectusedcars Limited | Wholesale & retail | 2016 |
| Selkirk Limited | Extraterritorial | 2023 |
| Semi-Permanent FX Limited | Other services | 2012 |
| Sense Adviser Services Limited | Financial services | 2011 |
| Sense Support Limited | Financial services | 2011 |
| Sequel Communications Limited | Professional & scientific | 2019 |
| Serendipity Events Limited | Administrative & support | 2019 |
| Serenity (Cheshire) Limited | Wholesale & retail | 1998 |
| Serenity Sourcing and Design Limited | Professional & scientific | 2018 |
| Serve Padel Club Limited | Arts & recreation | 2025 |
| Serve Padel Club Stafford Limited | Arts & recreation | 2026 |
| Serve Padel Club Stone Limited | Arts & recreation | 2025 |
| Serviced Accommodation Ltd | Real estate | 2025 |
| Seven Connect Ltd | Real estate | 2021 |
| Sevenoaks (Knutsford) Management Company Limited | Households | 2007 |
| Sevenshield SVR Advisors Ltd | Administrative & support | 2026 |
| Seventrees Securities Limited | Financial services | 1975 |
| SG Construction and Plant Services Ltd | Construction | 2024 |
| SG Roadmap Limited | Professional & scientific | 2024 |
| SGA Enterprises Ltd | Agriculture & fishing | 2019 |
| SGC Civil Engineering Ltd | Construction | 2005 |
| SGC Civil Holdings Limited | Financial services | 2021 |
| SGC Civil Plant Limited | Administrative & support | 2023 |
| SGC Incorporated Ltd | Wholesale & retail | 2023 |
| Shamoli (Knutsford) Ltd | Hospitality | 2015 |
| Shamoli Restaurant Limited | Hospitality | 2022 |
| Shankill Contractors Ltd | Construction | 2024 |
| Shankill Developments Limited | Hospitality | 2005 |
| Shape Consultancy Limited | Professional & scientific | 2007 |
| Share Smart Ltd | Information & communication | 2024 |
| Sharp Enterprise Ltd | Information & communication | 2009 |
| SHC Advisory Services Ltd | Professional & scientific | 2026 |
| SHE Beast Ltd | Arts & recreation | 2019 |
| Sheafmoor Money Management Limited | Financial services | 2004 |
| Sheldons Dairy Limited | Wholesale & retail | 2018 |
| Shine Associates Limited | Manufacturing | 2013 |
| Shire Professional Funding Limited | Financial services | 2010 |
| Shirland Properties (Crosby) Ltd | Real estate | 2006 |
| Shoots Consultancy Ltd | Professional & scientific | 2019 |
| Shoulder 2 Elbow Ltd | Health & social care | 2012 |
| Shred Academy Ltd | Health & social care | 2022 |
| Signed, Sealed, Delivered Limited | Administrative & support | 2019 |
| Silk Road Horizon Ltd | Education | 2019 |
| Silkdale Living Limited | Construction | 2015 |
| Silkmore Investments Limited | Real estate | 2022 |
| Simply Aesthetics Cheshire Limited | Other services | 2025 |
| Sister Barista Limited | Hospitality | 2021 |
| Sisu Virtual Assistant Ltd | Administrative & support | 2023 |
| Sivpro Ltd | Real estate | 2018 |
| SIX International Ltd | Wholesale & retail | 2022 |
| Sjcp Ltd | Professional & scientific | 2026 |
| SK9 Enterprises Limited | Manufacturing | 2018 |
| Skillman Veterinary Services Limited | Professional & scientific | 2017 |
| Skipper TM Limited | Professional & scientific | 2003 |
| SKS Entertainment Ltd | Extraterritorial | 2002 |
| Skuruvik Limited | Real estate | 2025 |
| Skye Avco Ltd | Professional & scientific | 2017 |
| SL Utility Consulting Ltd | Construction | 2024 |
| Slaters Property Group Ltd | Real estate | 2018 |
| Sleep-Focus.Com Ltd | Health & social care | 2023 |
| Smart Auto Repairs Limited | Wholesale & retail | 2012 |
| Smart Content Solutions Ltd | Professional & scientific | 2025 |
| Smartcode Solutions Limited | Information & communication | 2012 |
| SMC Heating & Plumbing Ltd | Construction | 2018 |
| Smfk Developments Limited | Real estate | 2017 |
| Smfk Investments Limited | Real estate | 2019 |
| Smfk Limited | Real estate | 2018 |
| SMG Imaging Limited | Health & social care | 2018 |
| Smiling Jacks Ltd | Professional & scientific | 2018 |
| Snips Snack Co Ltd | Wholesale & retail | 2023 |
| SNS North West Limited | Real estate | 2015 |
| Social Care Expert Solutions Limited | Health & social care | 2017 |
| Society of Business Practitioners Limited | Education | 1993 |
| Sohare Limited | Professional & scientific | 2026 |
| Solace Interactive Limited | Information & communication | 2025 |
| Solus Recruitment Ltd | Administrative & support | 2019 |
| Solutions for Marketing Limited | Professional & scientific | 1999 |
| Solvergy Limited | Professional & scientific | 2024 |
| SOM-3 Recruitment Limited | Administrative & support | 2018 |
| Sophie Freeman Limited | Professional & scientific | 2017 |
| Sotigris Ltd | Information & communication | 2026 |
| Soul Reformer Ltd | Arts & recreation | 2022 |
| South to North Consulting Ltd | Information & communication | 2022 |
| SP GAS & Heating Limited | Construction | 2003 |
| Sparkling Clean Agency Ltd | Administrative & support | 2019 |
| Sparkling Flues Limited | Administrative & support | 2015 |
| Specialist Instrument Services Limited | Extraterritorial | 1954 |
| Specialist Lamp Distributors Limited | Extraterritorial | 1955 |
| Specimen Trees Limited | Agriculture & fishing | 2014 |
| Spectrumx Direct Limited | Manufacturing | 2020 |
| Spectrumx Holdings UK Ltd | Financial services | 2021 |
| Spectrumx Medical Limited | Wholesale & retail | 2020 |
| Speedy Freight Limited | Administrative & support | 2017 |
| Speedy Parcels Limited | Administrative & support | 2025 |
| Spellbound Galleries Ltd | Wholesale & retail | 2021 |
| Spellbound Publications Limited | Other services | 2008 |
| Spencer Cleaners (Eccles) Limited | Real estate | 1961 |