| Spencer Grants Limited | Health & social care | 2022 |
| SPK Consulting Services (Cheshire) Limited | Professional & scientific | 2013 |
| SPM S9 Ltd | Administrative & support | 2015 |
| Sporting Pivot Ltd | Professional & scientific | 2025 |
| Sportspoint International Marketing Limited | Professional & scientific | 1997 |
| Spray Tone Coatings Ltd | Construction | 2013 |
| Spring Psychotherapy Limited | Education | 2019 |
| Square Space Investments Limited | Real estate | 2025 |
| SR Veterinary Group Ltd | Professional & scientific | 2020 |
| Srlco Holdings Limited | Financial services | 2019 |
| Srlco Limited | Administrative & support | 2009 |
| ST Barx Limited | Wholesale & retail | 2025 |
| ST Georges Close Limited | Households | 2002 |
| ST Raphael Healthcare Ltd | Construction | 2024 |
| ST. Arthur Homes Limited | Construction | 2006 |
| ST. Baldreds Estates Limited | Real estate | 2008 |
| Stable Minds C.I.C. | Health & social care | 2023 |
| Stacey LEE Brebner Limited | Manufacturing | 2018 |
| Standglen Limited | Financial services | 1992 |
| Star Feedback Limited | Administrative & support | 2023 |
| State Agent Ltd | Professional & scientific | 2023 |
| Station House Limited | Manufacturing | 1988 |
| Status Communications Solutions Limited | Information & communication | 2012 |
| Statutory Law Ltd | Financial services | 2018 |
| Stay at Owen House Farm Limited | Hospitality | 2016 |
| Steelandscape Limited | Manufacturing | 2023 |
| Step Forward RP Limited | Real estate | 2016 |
| Stephen Ashley (Electrical) Limited | Construction | 2004 |
| Stephen Douglas Software Development Ltd | Information & communication | 2018 |
| Stix and Roam Ltd | Wholesale & retail | 2018 |
| Stockdale Sacca Holdings Limited | Financial services | 2026 |
| Stolen Lamb Knutsford Ltd | Hospitality | 2025 |
| Stonebred Ltd | Real estate | 2024 |
| Stopford International Limited | Professional & scientific | 2013 |
| Stopford Limited | Professional & scientific | 1982 |
| Storm Air Ltd | Professional & scientific | 2010 |
| Stormright Limited | Construction | 2017 |
| Story Sport Franchising Limited | Arts & recreation | 2026 |
| Story Sport Limited | Arts & recreation | 2025 |
| Stove Munkey Ltd | Hospitality | 2019 |
| Stovewise of Cheshire Ltd | Construction | 2025 |
| Strategic Connections Limited | Administrative & support | 2004 |
| Stratos Property Development and Investment Consultants Limited | Professional & scientific | 2007 |
| Strong Chain Corporation Limited | Professional & scientific | 2000 |
| Stuart Broad Limited | Arts & recreation | 2006 |
| Stuart Crawford Consulting Ltd | Professional & scientific | 2008 |
| Stuart Rushton Limited | Administrative & support | 1998 |
| Student Savvy Limited | Information & communication | 2024 |
| Studio MCR Limited | Wholesale & retail | 2019 |
| Study Passport UK Ltd | Education | 2024 |
| Styal Homes Limited | Real estate | 2016 |
| Style Matters Holdings Ltd | Financial services | 2025 |
| Style Matters Limited | Manufacturing | 2002 |
| Subs Highstreet Ltd | Hospitality | 2024 |
| Sudlow Barns 167 Limited | Households | 2017 |
| Sugardigger Limited | Wholesale & retail | 2017 |
| Suits ME (Europe) Limited | Other services | 2019 |
| Suits ME 2 Ltd | Other services | 2025 |
| Suits ME Limited | Other services | 2010 |
| Summerhouse Productions Ltd. | Information & communication | 1997 |
| Sunday River Limited | Hospitality | 2017 |
| Sunnyside Pickmere Limited | Other services | 2020 |
| Sunset Chaser Ltd | Information & communication | 2023 |
| Supacrop Limited | Agriculture & fishing | 2021 |
| Supavan Limited | Manufacturing | 2025 |
| Superior Smiles (Knutsford) Limited | Health & social care | 2018 |
| Sure B2B Ltd | Manufacturing | 2020 |
| Sure Real Estate Ltd | Real estate | 2022 |
| Susanna Walton Limited | Health & social care | 2019 |
| Sutton Court Mansions Limited | Households | 2002 |
| SVM Legal Limited | Professional & scientific | 2020 |
| SW Trading and Shipping Ltd | Wholesale & retail | 2025 |
| Swanzy Services Limited | Extraterritorial | 2024 |
| Sweet. Knutsford Limited | Hospitality | 2026 |
| Swift Court Altrincham Limited | Extraterritorial | 2018 |
| Swift Rent a Car Limited | Administrative & support | 2015 |
| Swiftapp Design Ltd | Information & communication | 2014 |
| Swiftsure Holdings Ltd | Financial services | 2016 |
| Swiftsure Wealth Management Limited | Financial services | 2021 |
| Sworton Heath Estates Limited | Real estate | 2025 |
| Sxcha Ltd | Extraterritorial | 2021 |
| Sycom International Limited | Information & communication | 2015 |
| Sympatico Ventures Ltd | Health & social care | 2025 |
| Synergy Clinical Research & Medical Communications Limited | Professional & scientific | 1992 |
| T R Restaurant Ltd | Hospitality | 2019 |
| T S & G Properties LLP | | 2019 |
| T. M. Duche & Sons Limited | Hospitality | 1991 |
| T.M. Duche & Sons (UK) Ltd | Hospitality | 1992 |
| T.S. Industrial Products Limited | Extraterritorial | 1983 |
| T50 Gymnastics Club C.I.C. | Arts & recreation | 2025 |
| Tabley Brook Kennels Ltd | Agriculture & fishing | 2024 |
| Tabley Wood Holdings Limited | Transport & logistics | 2023 |
| Tace Liverpool Ltd | Professional & scientific | 2015 |
| Tace London Limited | Professional & scientific | 2013 |
| Tace Manchester Limited | Professional & scientific | 2013 |
| Tace Projects Limited | Professional & scientific | 2013 |
| Tachbrook Street (102) Freehold Limited | Households | 2013 |
| TAD Contracting Limited | Agriculture & fishing | 2022 |
| Tailored K9S Ltd | Agriculture & fishing | 2026 |
| Takebest Limited | Real estate | 1978 |