| Shanghai Yaoxiang Import & Export Co., Ltd | Extraterritorial | 2015 |
| Shanghai Yingzhijie Textile Co., Ltd | Administrative & support | 2008 |
| Shanghua Shipping Co., Limited | Extraterritorial | 2018 |
| Shangji Sports Equipments Co., Ltd | Administrative & support | 2023 |
| Sharkbite Plumbing Materials Company Limited | Extraterritorial | 2017 |
| Shawa Corporation Limited | Administrative & support | 2023 |
| Shaz Trading Ltd | Hospitality | 2023 |
| SHE Prints Ltd | Wholesale & retail | 2025 |
| Shengjun Clothing Co., Ltd | Administrative & support | 2021 |
| Shengtai Electronics Co., Ltd | Administrative & support | 2021 |
| Shengya Optical Co., Ltd | Extraterritorial | 2022 |
| Shenzhen HTL Display Co., Ltd | Administrative & support | 2023 |
| Shenzhen Sinos Technology Co., Ltd | Administrative & support | 2023 |
| Shenzhen Uniwise PCB Co., Ltd | Administrative & support | 2023 |
| Shenzhen WAN XIN ZE Technology Company Limited | Administrative & support | 2022 |
| Shenzhen Yuetoo Technology Co., Ltd | Administrative & support | 2021 |
| Shenzhou Chemical Co., Ltd | Administrative & support | 2026 |
| Shiftit.Net Limited | Professional & scientific | 1999 |
| Shilton Garage Ltd | Wholesale & retail | 2003 |
| Shine Bright Detailing Ltd | Administrative & support | 2025 |
| Shinesignal Technology Co., Ltd | Administrative & support | 2015 |
| Shining Ocean Co., Ltd | Wholesale & retail | 2020 |
| Shiny Technology Co., Ltd. | Administrative & support | 2026 |
| Shires Physio Ltd | Health & social care | 2012 |
| Shorwell Projects Limited | Construction | 2016 |
| Showing World Limited | Information & communication | 2021 |
| Showmelly Technology Co., Ltd | Extraterritorial | 2019 |
| Shri Ganesh Property Limited | Real estate | 2017 |
| Shrihaan Ltd | Real estate | 2024 |
| Shumii Limited | Information & communication | 2012 |
| Sibida Ltd | Administrative & support | 2017 |
| Sichuan Zhong Xing ZHI Cheng Automobile Sales Service Co., Ltd | Administrative & support | 2023 |
| Sidph Instrument Limited | Manufacturing | 2018 |
| Sienoo International Trading Limited | Wholesale & retail | 2018 |
| Silicon Codex Limited | Information & communication | 2013 |
| Silverback Stretch Tents Ltd | Wholesale & retail | 2022 |
| Silverberry Care Ltd | Health & social care | 2023 |
| Simmer Kitchens Ltd | Construction | 2014 |
| Simply LS Group Limited | Wholesale & retail | 2020 |
| Sinbel Trading Co., Limited | Extraterritorial | 2023 |
| Sinbond Industrial Co., Ltd. | Professional & scientific | 2014 |
| SINCE74 Limited | Information & communication | 2021 |
| Sino Shineway Industry Co., Ltd | Administrative & support | 2020 |
| Sinovol Technology & Development Co., Ltd | Extraterritorial | 2017 |
| Sinvo Electronics Co., Limited | Administrative & support | 2023 |
| Sioroager Co., Ltd | Wholesale & retail | 2022 |
| SIP Beverage Ltd | Hospitality | 2019 |
| Sircos IT Solutions Limited | Information & communication | 2003 |
| Site Development Co.(Midlands)Limited | Extraterritorial | 1954 |
| SIX Points International Co., Ltd | Wholesale & retail | 2021 |
| Sixtonine Limited | Professional & scientific | 1999 |
| SJ Medical Writing Ltd | Professional & scientific | 2014 |
| SJ Tree & Security Maintenance Ltd | Administrative & support | 2026 |
| Skan Properties Limited | Construction | 2006 |
| Skin Health Symposium UK Limited | Administrative & support | 2014 |
| Sknohsys Limited | Information & communication | 2007 |
| Skyboy Environmental Science and Technology Co., Ltd | Extraterritorial | 2017 |
| Slaters Ltd | Construction | 2025 |
| Sline Electric Co., Ltd. | Extraterritorial | 2017 |
| Sllic Property Services Limited | Real estate | 2026 |
| SM Carpentry & Construction (Midlands) Ltd | Construction | 2024 |
| Small Olive Company Ltd | Wholesale & retail | 2026 |
| Smart Awards Limited | Education | 2014 |
| Smart Image Furniture Limited | Administrative & support | 2007 |
| Smart Kidz Academy Ltd | Education | 2013 |
| Smarter Regulation Solutions Ltd | Professional & scientific | 2025 |
| Smiles & Handshakes Ltd | Real estate | 2025 |
| SMK Supplies Limited | Hospitality | 2025 |
| SMP Surfacing Solutions Limited | Construction | 2005 |
| SMR Business Enterprises Ltd | Professional & scientific | 2022 |
| Snas Developments Ltd | Real estate | 2022 |
| Snas Mechanical Ltd | Construction | 2022 |
| Soak UP the Sun Limited | Construction | 2010 |
| Sobek Commerce Co., Ltd | Extraterritorial | 2025 |
| Sobek Nexus Co., Ltd | Extraterritorial | 2025 |
| Social Sync Ltd | Professional & scientific | 2021 |
| Socialstack Ltd. | Information & communication | 2019 |
| SOL Intl Co., Ltd | Extraterritorial | 2017 |
| Solid People Limited | Administrative & support | 2009 |
| Solid Solutions Group Ltd | Financial services | 2020 |
| Solid Solutions Holdings Ltd | Professional & scientific | 2016 |
| Solid Solutions International Ltd | Financial services | 2020 |
| Solid Solutions Management Limited | Information & communication | 1998 |
| Solihull Health Club Limited | Arts & recreation | 2019 |
| Solisnet Ltd | Information & communication | 2013 |
| Solo Health Ltd | Health & social care | 2020 |
| Solomon Hospitality Group Limited | Information & communication | 2022 |
| Soma Control Systems Ltd | Water & waste | 2022 |
| Soma Group of Companies Limited | Water & waste | 2022 |
| Soma Services Limited | Water & waste | 2000 |
| Sonder Communications Limited | Professional & scientific | 2015 |
| Sonokim Ltd | Information & communication | 2025 |
| Sonrisa Arts CIC | Arts & recreation | 2022 |
| Soonius Chiropractic Limited | Health & social care | 2014 |
| Sorony Limited | Hospitality | 2013 |
| Sourcing 360 Services Ltd | Manufacturing | 2012 |
| SP19 Properties Ltd | Real estate | 2026 |
| Spa Investments Ltd | Construction | 1943 |
| Spa Property Holdings Limited | Real estate | 2019 |
| Sparex Holdings Limited | Professional & scientific | 2005 |