| Sparks Marketing (Emea) Limited | Administrative & support | 2013 |
| Special Agent Limited | Real estate | 2012 |
| Spectrum Health PVT Ltd | Health & social care | 2023 |
| Spectrum Portfolio Management Ltd | Health & social care | 2016 |
| Specx Instrument Limited | Manufacturing | 2024 |
| SPF Solutions Limited | Professional & scientific | 2010 |
| Spiltmilk Dance | Arts & recreation | 2015 |
| Spin Strategy Ltd | Professional & scientific | 2026 |
| Splash PR Limited | Professional & scientific | 2011 |
| Spot on Curtains, Blinds and Shutters Ltd | Manufacturing | 2022 |
| Spring Yuan Ltd | Wholesale & retail | 2024 |
| Springboard Management Solutions Limited | Professional & scientific | 2005 |
| Spxcases Ltd | Wholesale & retail | 2023 |
| Square Goose Ltd | Professional & scientific | 2023 |
| Squire & Squire Photography Ltd | Professional & scientific | 2006 |
| Ssamarasekera Ltd | Health & social care | 2022 |
| SSS 2025 Limited | Hospitality | 2025 |
| SSS UK Secretary Co., Ltd | Professional & scientific | 2018 |
| ST Augustine's Kids Club Ltd. | Education | 2010 |
| ST Prism Limited | Wholesale & retail | 2019 |
| Stable Print Limited | Manufacturing | 2014 |
| Stack Communications Ltd | Information & communication | 2015 |
| Staedter Limited | Information & communication | 2021 |
| Standoon Limited | Wholesale & retail | 2021 |
| Stanley Forestry Limited | Agriculture & fishing | 2025 |
| Star Telecoms Limited | Information & communication | 2026 |
| Starco Paper (Shanghai) Co., Ltd. | Extraterritorial | 2010 |
| Starjet Co., Ltd | Administrative & support | 2024 |
| Stark Roofing Ltd | Construction | 2024 |
| Stayy Ltd | Hospitality | 2021 |
| Stephanie Anne Ltd | Other services | 2022 |
| Stiller Design Ltd | Professional & scientific | 2008 |
| Stockton Fisheries Limited | Arts & recreation | 2026 |
| Stone Trace Trading Limited | Administrative & support | 2022 |
| Stoneleigh Abbey Events Limited | Administrative & support | 2002 |
| Stoneleigh Abbey Limited | Arts & recreation | 1996 |
| Stonewood Holdings Limited | Extraterritorial | 1975 |
| Stonewood Securities Limited | Real estate | 1922 |
| Stop HS2 Limited | Professional & scientific | 2010 |
| Strata Management Support Limited | Professional & scientific | 2020 |
| Stratton Programmes & Projects Ltd | Professional & scientific | 2026 |
| Strength and Salad Limited | Health & social care | 2022 |
| Strike Exchange Ltd | Professional & scientific | 2015 |
| Studio 32 Ltd | Arts & recreation | 2022 |
| Studio Dowlen Ltd | Professional & scientific | 2025 |
| Stylestate Co. Ltd | Extraterritorial | 2024 |
| Success Co., Limited | Administrative & support | 2024 |
| Success Sino Ltd | Administrative & support | 2022 |
| SUE Malone Limited | Professional & scientific | 2013 |
| Sukis Canine Rescue Crew C.I.C. | Other services | 2012 |
| Sulinda Sole Trader Company Ltd | Transport & logistics | 2016 |
| Sumec Electric Appliances Co., Ltd | Manufacturing | 2019 |
| Summer Foods Co., Ltd | Agriculture & fishing | 2017 |
| Sun Fast Trading Co., Ltd | Administrative & support | 2020 |
| Suneye IMP. & EXP. Co., Limited | Extraterritorial | 2017 |
| Sung EUN Fashion Jewelry Co., Ltd. | Professional & scientific | 2019 |
| Sunkari Digbeth 1 Ltd | Construction | 2023 |
| Sunkari Group Limited | Financial services | 2022 |
| Sunkari Investments Limited | Financial services | 2022 |
| Sunkari Ltd | Construction | 2020 |
| Sunkari Nelson 2 Ltd | Construction | 2025 |
| Sunkari Nelson One Ltd | Financial services | 2023 |
| Sunkari Solihull 1 Ltd | Construction | 2025 |
| Sunmore Co., Ltd | Administrative & support | 2022 |
| Sunny Link Shipping Co., Limited | Extraterritorial | 2019 |
| Sunrise International Co., Ltd | Administrative & support | 2025 |
| Sunrise Sounds Ltd | Arts & recreation | 2025 |
| Sunrose Properties Limited | Real estate | 1994 |
| Sunshine International Group Co., Ltd. | Wholesale & retail | 2018 |
| Super Huhe Industrial Co., Ltd | Wholesale & retail | 2023 |
| Supertech Co., Ltd | Administrative & support | 2021 |
| Supremetech Limited | Real estate | 2011 |
| Suriti Group Limited | Extraterritorial | 2017 |
| Susan Resource Co., Ltd | Administrative & support | 2023 |
| Suzhou River Textile Co., Ltd | Extraterritorial | 2017 |
| SW 812 Limited | Financial services | 2018 |
| Swan Learning Limited | Information & communication | 2014 |
| Swba Solutions Limited | Administrative & support | 2025 |
| Sweat the Assets Limited | Arts & recreation | 2004 |
| Sweetwater Specialist Accommodation Limited | Real estate | 2025 |
| Swift Build Coventry Ltd | Construction | 2020 |
| Swift Civils Ltd | Construction | 2024 |
| Swift Pave Ltd | Construction | 2019 |
| Swift Properties Coventry Ltd | Real estate | 2024 |
| Swift Trade Management Co., Ltd | Administrative & support | 2023 |
| Swiftcertain Property Management Limited | Households | 1995 |
| Swiss 957 Limited | Professional & scientific | 2021 |
| Symon Investium Ltd | Real estate | 2025 |
| Syscomm Ltd. | Information & communication | 1984 |
| System Floors-Modech Limited | Extraterritorial | 2003 |
| Systems Finance Holdings Limited | Professional & scientific | 2006 |
| Systems Finance Limited | Financial services | 1995 |
| Systems Modelling Limited | Professional & scientific | 2017 |
| SZ Shengyi Trading Co Ltd | Administrative & support | 2023 |
| T & J Walters Limited | Real estate | 1997 |
| T & T Training Limited | Administrative & support | 2000 |
| T E K Freight Limited | Other services | 2018 |
| T J Lindsey Limited | Construction | 2017 |
| T S J Consultants Limited | Manufacturing | 2003 |
| T Sparkes Electrical Limited | Extraterritorial | 2014 |