| Sevens Holding Ltd | Real estate | 2024 |
| SF Socialcare Ltd | Health & social care | 2021 |
| SFK Consultancy Limited | Administrative & support | 2017 |
| Sfki Enterprise Ltd | Wholesale & retail | 2022 |
| SFW Consultancy Yorkshire Limited | Professional & scientific | 2025 |
| SG Pristine Cleaning Services Ltd | Administrative & support | 2025 |
| Sgaw TM Ltd | Construction | 2021 |
| SH Travel Service Ltd | Transport & logistics | 2024 |
| Shaalom Osher Limited | Real estate | 2025 |
| Shaban Property Management Ltd | Real estate | 2021 |
| Shafi Housing Ltd | Real estate | 2023 |
| Shahid Transport Service Ltd | Transport & logistics | 2020 |
| Sham Shawarma (BD) Ltd | Hospitality | 2025 |
| Shamal Creatives Ltd | Administrative & support | 2013 |
| Sharma Builders 1 Limited | Construction | 2026 |
| Sharmina Smile & Hygiene Ltd | Health & social care | 2024 |
| Sharondaymaths Limited | Administrative & support | 2011 |
| Shaun Coombes Ltd | Extraterritorial | 2024 |
| Shaw Investment (Keighley) Ltd | Financial services | 2024 |
| Shay Grange Golf Centre Limited | Arts & recreation | 2006 |
| Shazia Iqbal Ltd | Other services | 2020 |
| Shazpak Limited | Wholesale & retail | 2024 |
| Shean & Sons Ltd | Health & social care | 2023 |
| Sheguftab Ltd | Professional & scientific | 2023 |
| Shepherd Online Ltd | Information & communication | 2024 |
| Sheridan Mount Care Homes Ltd | Health & social care | 2026 |
| Sherry Ltd | Real estate | 2013 |
| Sherwell Construction Ltd | Construction | 2025 |
| Sheryn Consulting Ltd | Professional & scientific | 2024 |
| Shieldserve Services Ltd | Administrative & support | 2025 |
| Shillelagh Property Limited | Real estate | 2022 |
| Shimla Burnley LLP | | 2014 |
| Shimla Yorkshire Wholesale Limited | Wholesale & retail | 2018 |
| Shine Properties (Yorkshire) Limited | Real estate | 2017 |
| Ship Inn (ALD) Ltd | Hospitality | 2025 |
| Shiv Home Developments (CMC) Ltd | Construction | 2025 |
| Shiv Property Management Limited | Real estate | 2004 |
| SHN Enterprise Limited | Transport & logistics | 2025 |
| Shokar Motors Limited | Wholesale & retail | 2021 |
| Shoperazz Ltd | Wholesale & retail | 2026 |
| Shopvexa Ltd | Wholesale & retail | 2025 |
| Short Circuit Solutions Limited | Information & communication | 1999 |
| Shotzsnooker Ltd | Arts & recreation | 2021 |
| Showfield Motors Ltd | Wholesale & retail | 2018 |
| Shreyas Cottages Ltd | Real estate | 2006 |
| Shukran Industries Private Limited | Wholesale & retail | 2024 |
| Shussain Healthcare Limited | Other services | 2016 |
| Shvan & Rebaz Group Limited | Manufacturing | 2025 |
| Sias Engineering Services Limited Partnership | | 2000 |
| Sibs - for Brothers and Sisters | Health & social care | 2011 |
| Sica Support Limited | Professional & scientific | 2012 |
| Sid's Kitchen Ltd | Hospitality | 2025 |
| Siddhi Vinayaka Limited | Hospitality | 2024 |
| Sidegate Farm Limited | Agriculture & fishing | 2004 |
| Sightwise Ltd | Health & social care | 2024 |
| Sign & Design Limited | Manufacturing | 1990 |
| Signature Crafts Ltd | Wholesale & retail | 2018 |
| Signature Stairlifts Limited | Manufacturing | 2013 |
| Silsden Business Park Management Company Limited | Real estate | 2008 |
| Silsden Cars Ltd | Administrative & support | 2017 |
| Silsden Mobiles Limited | Other services | 2017 |
| Silsden News Ltd | Wholesale & retail | 2022 |
| Silsden Osteopathy Limited | Health & social care | 2022 |
| Silsden Plumbing & Heating Ltd | Construction | 2012 |
| Silsden Safety Consultants Limited | Professional & scientific | 2025 |
| Silsden Self Storage Ltd | Real estate | 2023 |
| Silsden Steeton Cottingley & NAB Wood Limited | Transport & logistics | 2010 |
| Silsden Steeton Properties Ltd | Real estate | 2023 |
| SILVERCARE786 Ltd | Public administration | 2024 |
| Silverland of Haworth Limited | Wholesale & retail | 2011 |
| Silverstone Sports Cars Ltd | Wholesale & retail | 2013 |
| Simfass Ltd | Real estate | 2012 |
| Simon & Simon Horticulture Limited | Administrative & support | 2021 |
| Simon Bridge Woodmachinery Ltd | Wholesale & retail | 2013 |
| Simon Wray Consulting Limited | Professional & scientific | 1998 |
| Simonside Medical and Logistics Ltd | Health & social care | 2019 |
| Simple Convenience Group Ltd | Wholesale & retail | 2026 |
| Simply Classic Limited | Hospitality | 2021 |
| Simply Ventilation Limited | Manufacturing | 2020 |
| Simpson Homes Limited | Construction | 2021 |
| Simpson-Kidd Taekwondo Limited | Education | 2020 |
| Simran & Gianni Property Limited | Real estate | 2014 |
| Simx Ltd | Agriculture & fishing | 2023 |
| Singh Shop Ltd | Wholesale & retail | 2026 |
| Sipling & Co Limited | Professional & scientific | 2015 |
| Sirius Collaboration Ltd | Information & communication | 2018 |
| Site Link Software (7 Group) Limited | Wholesale & retail | 2022 |
| Sjad Properties Ltd | Real estate | 2023 |
| SJH Property Ltd | Real estate | 2017 |
| SJO Homes Limited | Real estate | 2026 |
| SJP Property Enterprises Ltd | Real estate | 2025 |
| SJV Property Services Limited | Real estate | 2001 |
| SK Collective Limited | Wholesale & retail | 2025 |
| Skaife Limited | Real estate | 2024 |
| Skin by DR Tanzi Ltd | Health & social care | 2025 |
| Skinthetics Yorkshire Ltd | Other services | 2024 |
| Skinviva Ltd | Other services | 2010 |
| Skipton Dairy Services Limited | Professional & scientific | 2025 |
| Skipton Screeds & Plastering Limited | Construction | 2021 |
| Skipton Signs Ltd | Manufacturing | 2025 |